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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

黏液蛋白信号在转移中的病理意义

卷 23, 期 8, 2023

发表于: 11 May, 2023

页: [585 - 602] 页: 18

弟呕挨: 10.2174/1568009623666230320121332

价格: $65

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摘要

动态粘膜层为体腔上皮细胞提供了选择性的保护屏障。多种人类恶性肿瘤利用其内在作用来保护和修复上皮，促进生长和生存。已知黏液蛋白的异常表达与许多癌症的不良预后有关。然而，在转移研究中出现的新范式认识到MUC1、MUC4、MUC5AC、MUC5B和MUC16参与了转移的发生和进展。因此，粘蛋白可以作为一个有吸引力的目标，在未来的诊断和治疗策略。本文就黏液蛋白家族及其结构域以及不同黏液蛋白在调节肿瘤进展和转移中的作用作一综述。此外，我们简要地讨论了粘蛋白作为治疗剂的见解。

关键词: 粘蛋白家族，粘蛋白结构域，分泌性粘蛋白，跨膜粘蛋白，转移，生物标志物，治疗靶点。

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图形摘要

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