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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Review Article

A Review on Antidiabetic Potential of Genus Ferula (Apiaceae)

Author(s): Seyyed Majid Bagheri, Elham Hakimizadeh and Mohammad Allahtavakoli*

Volume 10, Issue 1, 2024

Published on: 17 April, 2023

Article ID: e090323214509 Pages: 9

DOI: 10.2174/2215083809666230309111323

Price: $65

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Abstract

Background: One of the most important metabolic disorders in the current century is diabetes, which can negatively affect the physiology of many body parts. Unfortunately, this disease is not limited to a specific part of the body and causes destructive effects on the nervous system, cardiovascular system, kidneys and many other parts of the body. The high costs and increasing prevalence of this disease have made scientists look for natural compounds to prevent and treat diabetes. Medicinal plants are a huge source of unknown compounds that can alleviate many human diseases.

Objective: One of the oldest plant families that have been used medicinally is the Apiaceae family. One of the most important genera of this family is Ferula, which has 170 different species and is distributed in hot and dry regions of the earth and has various therapeutic properties. The purpose of this article is to review the anti-diabetic effects of the Ferula genus on diabetes.

Methods: In this review article, key science databases, including Science Direct, PubMed, and Google Scholar, were searched to find information on Ferula genus using a combination of different keywords, including diabetes, hyperglycemia, and alpha-glucosidase inhibition.

Results: A total of 9 types of Ferula have been reported in the articles that have anti-diabetic properties.

Conclusion: The review of the conducted research shows that the genus Ferula has a high potential in reducing blood sugar and other aspects of diabetes, and additional research should be performed in this field.

Keywords: Ferula, diabetes mellitus, hyperglycemia, Apiaceae, sulfide components, sesquiterpene coumarins.

Graphical Abstract

[1]
Clark CM Jr, Lee DA. Prevention and treatment of the complications of diabetes mellitus. N Engl J Med 1995; 332(18): 1210-7.
[http://dx.doi.org/10.1056/NEJM199505043321807] [PMID: 7700316]
[2]
Alam U, Asghar O, Azmi S, Malik RA. General aspects of diabetes mellitus. Handb Clin Neurol 2014; 126: 211-22.
[http://dx.doi.org/10.1016/B978-0-444-53480-4.00015-1] [PMID: 25410224]
[3]
Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019; p. 157: 107843.
[http://dx.doi.org/10.1016/j.diabres.2019.107843] [PMID: 31518657]
[4]
Roden M. Diabetes mellitus: Definition, classification and diagnosis. Wien Klin Wochenschr 2016; 128(S2): 37-40.
[http://dx.doi.org/10.1007/s00508-015-0931-3] [PMID: 27052219]
[5]
Tornio A, Niemi M, Neuvonen PJ, Backman JT. Drug interactions with oral antidiabetic agents: Pharmacokinetic mechanisms and clinical implications. Trends Pharmacol Sci 2012; 33(6): 312-22.
[http://dx.doi.org/10.1016/j.tips.2012.03.001] [PMID: 22475684]
[6]
Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and modern medicine from natural products. Molecules 2016; 21(5): 559.
[http://dx.doi.org/10.3390/molecules21050559] [PMID: 27136524]
[7]
Amiri MS, Joharchi MR. Ethnobotanical knowledge of Apiaceae family in Iran: A review. Avicenna J Phytomed 2016; 6(6): 621-35.
[PMID: 28078243]
[8]
Christensen LP, Brandt K. Bioactive polyacetylenes in food plants of the Apiaceae family: Occurrence, bioactivity and analysis. J Pharm Biomed Anal 2006; 41(3): 683-93.
[http://dx.doi.org/10.1016/j.jpba.2006.01.057] [PMID: 16520011]
[9]
Moran J, van Rijswijk B, Traicevski V, Kitajima EW, Mackenzie AM, Gibbs AJ. Potyviruses, novel and known, in cultivated and wild species of the family Apiaceae in Australia. Arch Virol 2002; 147(10): 1855-67.
[http://dx.doi.org/10.1007/s00705-002-0865-8] [PMID: 12376749]
[10]
Bagheri SM, Dashti-R MH, Morshedi A. Antinociceptive effect of Ferula assa-foetida oleo-gum-resin in mice. Res Pharm Sci 2014; 9(3): 207-12.
[PMID: 25657791]
[11]
Dastan D, Validi S, Ebadi A. Kamonolol acetate from Ferula pseudalliacea as AChE inhibitor: In vitro and in silico studies. Struct Chem 2020; 31(3): 965-73.
[http://dx.doi.org/10.1007/s11224-019-01473-z]
[12]
Abbasnia VS, Aeinfar H. Anxiolytic and hypnotic effect of Ferula assafoetida aqueous extract in mice. Int J Pharm Technol 2016; 8: 15974-9.
[13]
Ebrahimzadeh MA, Nabavi SM, Nabavi SF, Dehpour AA. Antioxidant activity of hydroalcholic extract of Ferula gummosa Boiss roots. Eur Rev Med Pharmacol Sci 2011; 15(6): 658-64.
[PMID: 21796870]
[14]
Lamnaouer D. [Anticoagulant activity of coumarins from Ferula communis L Therapie 1999; 54(6): 747-51.
[PMID: 10709451]
[15]
Rezvani ME, Vahidi AR, Esmaili M, Bagheri SM. Anticonvulsant effect of Ferula assa-foetida oleo gum resin on chemical and amygdala-kindled rats. N Am J Med Sci 2014; 6(8): 408-12.
[http://dx.doi.org/10.4103/1947-2714.139296] [PMID: 25210675]
[16]
Hejazian SH, Dashti-R MH, Bagheri SM. The relaxant effect of seed fs essential oil and oleo-gum-resin of Ferula assa-foetida on isolated rat’s ileum. Ann Med Health Sci Res 2014; 4(2): 238-41.
[http://dx.doi.org/10.4103/2141-9248.129050] [PMID: 24761245]
[17]
Adiga S, Bhat P, Chaturvedi A, Bairy KL, Kamath S. Vijayalakshmi. Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats. Indian J Pharmacol 2012; 44(1): 82-7.
[http://dx.doi.org/10.4103/0253-7613.91873] [PMID: 22345876]
[18]
Bagheri SM, Dashti-R MH. Influence of asafoetida on prevention and treatment of memory impairment induced by d-galactose and NaNO2 in mice. Am J Alzheimers Dis Other Demen 2015; 30(6): 607-12.
[http://dx.doi.org/10.1177/1533317515576388] [PMID: 25788433]
[19]
Xu A, Shang-Guan J, Li Z, Gao Z, Huang YC, Chen Q. Effects of dietary asafoetida (Ferula sinkiangensis K. M. Shen) levels on feeding attraction activity, growth performance, healthiness, and digestive enzyme activity in juvenile Lateolabrax japonicus. Fish Physiol Biochem 2020; 46(6): 1991-2003.
[http://dx.doi.org/10.1007/s10695-020-00849-x] [PMID: 32681211]
[20]
Ozkan H, Yanmis D, Karadayi M, Bal T, Baris O, Gulluce M. Determination of genotoxic and antigenotoxic properties of essential oil from Ferula orientalis L. using Ames/Salmonella and E. coli WP2 bacterial test systems. Toxicol Ind Health 2014; 30(8): 714-23.
[http://dx.doi.org/10.1177/0748233712462479] [PMID: 23064766]
[21]
Latifi E, Mohammadpour AA. H BF, Nourani H. Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats. Biomed Pharmacother 2019; 110: 197-202.
[http://dx.doi.org/10.1016/j.biopha.2018.10.152] [PMID: 30471513]
[22]
Iranshahi M, Alizadeh M. Antihyperglycemic effect of asafoetida (Ferula assafoetida oleo-gum-resin) in streptozotocin-induced diabetic rats. World Appl Sci J 2012; 17(2): 157-62.
[23]
Deveci E, Tel-Çayan G, Duru ME. Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts of Ferula elaeochytris and Sideritis stricta. Int J Food Prop 2018; 21(1): 771-83.
[http://dx.doi.org/10.1080/10942912.2018.1431660]
[24]
Kumar TB, Reddy DVJ, Rushendran R, Mamatha T, Roja J, Roopavani T. Antidepressant activity of ethanolic extract of oleo gum resins of Ferula asafoetida Linn. J Pre-Clin Clin Res 2017; 11(1): 50-60.
[http://dx.doi.org/10.26444/jpccr/75721]
[25]
Bagheri S, Yadegari M, Zare-Mohazabiye F, et al. Effect of Ferula assafoetida oleo-gum-resin on gastric ulcer in indomethacin-ulcerated rats. J Curr Res Sci Med 2018; 4(1): 42.
[http://dx.doi.org/10.4103/jcrsm.jcrsm_48_17]
[26]
Bagheri SM, Abdian-Asl A, Moghadam MT, et al. Antitumor effect of Ferula assafoetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice. J Ayurveda Integr Med 2017; 8(3): 152-8.
[http://dx.doi.org/10.1016/j.jaim.2017.02.013] [PMID: 28690055]
[27]
Bagheri S, Yadegari M, Behpur M, Javidmehr D. Antilithiatic and hepatoprotective effects of Ferula assa-foetida oleo-gum-resin on ethylene glycol-induced lithiasis in rats Urol Sci 2018; 0(0): 0.
[http://dx.doi.org/10.4103/UROS.UROS_10_18]
[28]
Bagheri SM, Maghsoudi MJ, Yadegari M. Preventive effect of Ferula asafoetida oleo gum resin on histopathology in cuprizone-induced demyelination mice. Int J Prev Med 2020; 11: 179.
[PMID: 33456735]
[29]
Shieh A, Bagheri SM, Yadegari M, Javidmehr D, Farhadi Z. Therapeutic effect of Ferula assa-foetida oleo-gum resin in rats with letrozole-induced polycystic ovary syndrome. Clin Exp Reprod Med 2022; 49(4): 269-47.
[http://dx.doi.org/10.5653/cerm.2022.05449] [PMID: 36482498]
[30]
Sayed-Ahmad B, Talou T, Saad Z, Hijazi A, Merah O. The Apiaceae: Ethnomedicinal family as source for industrial uses. Ind Crops Prod 2017; 109: 661-71.
[http://dx.doi.org/10.1016/j.indcrop.2017.09.027]
[31]
Bagheri SM, Hejazian SH, Bafghi AF. Antileishmanial activity of Ferula assa-foetida oleo gum resin against Leishmania major: An in vitro study. J Ayurveda Integr Med 2014; 5(4): 223-6.
[http://dx.doi.org/10.4103/0975-9476.146567] [PMID: 25624696]
[32]
Abu-Zaiton AS. Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pak J Biol Sci 2010; 13(2): 97-100.
[http://dx.doi.org/10.3923/pjbs.2010.97.100] [PMID: 20415145]
[33]
Rahbarian R. Investigating the effects of aqueous extract of asafoetida resin on the serum level of insulin and blood glucose in type 1 diabetic rats. J Shahrekord Uuniversity Med Sci 2014; 16(3): 16-21.
[34]
Azizian H, Rezvani ME. Anti-obesity, fat lowering and liver steatosis protective effects of Ferula asafoetida gum in type 2 diabetic rats: Possible involvement of leptin. IJDO 2012; 4(3): 120-6.
[35]
Rafiee S, Mojadadi MS, Molavi M, Nazemi S. Effect of ethyl acetate extract of Ferula asafoetida oleo-gum resin on the glucose level and lipid profile in streptozotocin-induced diabetic rats. Jundishapur J Nat Pharm Prod 2019; 15(2)
[http://dx.doi.org/10.5812/jjnpp.67042]
[36]
Yarizade A, Kumleh HH, Niazi A. In vitro antidiabetic effects of Ferula assa-foetida extracts through dipeptidyl peptidase iv and α-glucosidase inhibitory activity. In Vitro 2017; 10(5): 357.
[37]
Helal EGE, Mostafa AM. MhMood AF, Kahwash AA. Hypoglycemic and hyperinsulinemic effects of Ferula assafoetida on diabetic male albino rats. Egypt J Hosp Med 2005; 21(1): 95-108.
[http://dx.doi.org/10.21608/ejhm.2005.18052]
[38]
Rahbarian R. SEPEHRI MH, Sadoughi SD. Effect of aqueous extract of Ferula assa-foetida and avicennia marina on oxidative stress parameters of brian cells in diabetic rats. Feyz 2017; 21(4): 305-16.
[39]
Azari M, Mohiti-ardekani J, Abedini S, Mozayan MR. Effect of Ferula assafoetida on cytoplasmic membrane glucose transporter isotype-4 of C2C12 cell line. Int J Med Lab 2014; 1(1): 46-53.
[40]
Nazemi S, Rudsarabi H, Amin B, Farahani H, Zarmehri HA, Mojadadi MS. Anti-neuropathic pain effects of ethyl acetate extract of Ferula asafoetida oleo-gum-resin in streptozotocin-induced diabetic rats. Nat Prod J 2021; 11(4): 546-52.
[http://dx.doi.org/10.2174/2210315510999200628040218]
[41]
Esmailidehaj M, Kahtenaroon M, Rezvani ME, Azizian H, Ranjbar A. Enriched-asafoetida diet attenuates hyperglycemia, oxidative stress and endothelial dysfunction in type 2 diabetic rats. Physiol Pharmacol 2022; 26(1): 7-19.
[http://dx.doi.org/10.52547/phypha.26.1.8]
[42]
Sadraei H, Asghari GR, Hajhashemi V, Kolagar A, Ebrahimi M. Spasmolytic activity of essential oil and various extracts of Boiss. on ileum contractions. Phytomedicine 2001; 8(5): 370-6.
[http://dx.doi.org/10.1078/0944-7113-00052] [PMID: 11695880]
[43]
Sayyah M, Mandgary A, Kamalinejad M. Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. J Ethnopharmacol 2002; 82(2-3): 105-9.
[http://dx.doi.org/10.1016/S0378-8741(02)00166-6] [PMID: 12241984]
[44]
Ghasemi Y, Faridi P, Mehregan I, Mohagheghzadeh A. Ferula gummosa fruits: An aromatic antimicrobial agent. Chem Nat Compd 2005; 41(3): 311-4.
[http://dx.doi.org/10.1007/s10600-005-0138-3]
[45]
Jalili-Nik M, Soukhtanloo M, Javanshir S, et al. Effects of ethanolic extract of Ferula gummosa oleo-resin in a rat model of streptozotocin-induced diabetes. Res Pharm Sci 2019; 14(2): 138-45.
[http://dx.doi.org/10.4103/1735-5362.253361] [PMID: 31620190]
[46]
Karimlar S, Naderi A, Mohammadi F, et al. Hypoglycemic and hypolipidemic effects of Myrtus communis, Trachyspermum copticum and Ferula gummosa essential oils on streptozotocin induced diabetic rats. Nutrition and Food Sciences Research 2019; 6(1): 1-8.
[http://dx.doi.org/10.29252/nfsr.6.1.1]
[47]
Heydari-Majd M, Rezaeinia H, Shadan MR, Ghorani B, Tucker N. Enrichment of zein nanofibre assemblies for therapeutic delivery of Barije (Ferula gummosa Boiss) essential oil. J Drug Deliv Sci Technol 2019; 54101290
[http://dx.doi.org/10.1016/j.jddst.2019.101290]
[48]
Zengin G, Uysal A, Diuzheva A, et al. Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: A multi-functional insight. J Pharm Biomed Anal 2018; 160: 374-82.
[http://dx.doi.org/10.1016/j.jpba.2018.08.020] [PMID: 30121555]
[49]
Doğan HH, Duman R. The anti Hrsv activity of Ferula halophila peşmen aqueous and methanol extract by Mtt assay. Trak Univ J Nat Sci 2021.
[50]
Habibi Z, Salehi P, Yousefi M, et al. Chemical composition and antimicrobial activity of the essential oils of Ferula latisecta and Mozaffariania insignis from Iran. Chem Nat Compd 2006; 42(6): 689-92.
[http://dx.doi.org/10.1007/s10600-006-0253-9]
[51]
Javanshir S, Soukhtanloo M, Jalili-Nik M, Yazdi AJ, Amiri MS, Ghorbani A. Evaluation potential antidiabetic effects of Ferula latisecta in streptozotocin-induced diabetic rats. J Pharmacopuncture 2020; 23(3): 158-64.
[http://dx.doi.org/10.3831/KPI.2020.23.3.158] [PMID: 33072413]
[52]
Sattar Z, Iranshahi M. Phytochemistry and pharmacology of Ferula hermonis Boiss.- A review. Drug Res 2017; 67(8): 437-46.
[http://dx.doi.org/10.1055/s-0043-109100] [PMID: 28521374]
[53]
Raafat K, El-Lakany A. Acute and subchronic in-vivo effects of Ferula hermonis L. and Sambucus nigra L. and their potential active isolates in a diabetic mouse model of neuropathic pain. BMC Complement Altern Med 2015; 15(1): 257.
[http://dx.doi.org/10.1186/s12906-015-0780-7] [PMID: 26220172]
[54]
Ghareeb DA, ElAhwany AMD, El-mallawany SM, Saif AA. In vitro screening for anti-acetylcholiesterase, anti-oxidant, anti-glucosidase, anti-inflammatory and anti-bacterial effect of three traditional medicinal plants. Biotechnol Biotechnol Equip 2014; 28(6): 1155-64.
[http://dx.doi.org/10.1080/13102818.2014.969877] [PMID: 26740784]
[55]
Miski M, Ulubelen A, Mabry TJ. Six sesquiterpene alcohol esters from Ferula elaeochytris. Phytochemistry 1983; 22(10): 2231-3.
[http://dx.doi.org/10.1016/S0031-9422(00)80153-3]
[56]
Uyar A, Yaman T, Keles OF, et al. Reduction of hepatorenal and pancreatic damage by Ferula elaeochytris extract in STZ induced diabetic rats. Biotech Histochem 2021; 96(1): 28-40.
[http://dx.doi.org/10.1080/10520295.2020.1753239] [PMID: 32396744]
[57]
Thorve VS, Kshirsagar AD, Vyawahare NS, Joshi VS, Ingale KG, Mohite RJ. Diabetes-induced erectile dysfunction: Epidemiology, pathophysiology and management. J Diabetes Complications 2011; 25(2): 129-36.
[http://dx.doi.org/10.1016/j.jdiacomp.2010.03.003] [PMID: 20462773]
[58]
Eser N, Buyuknacar HS, Cimentepe OO, et al. The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat. Int J Impot Res 2020; 32(2): 186-94.
[http://dx.doi.org/10.1038/s41443-019-0137-8] [PMID: 30979969]
[59]
Uslu H, Elis T, Uslu GA, Makav M. A natural resource with antidiabetic, antihyperglycemic, antihyperlipidemic and cardioprotective effects: Ferula orientalis. Fresenius Environ Bull 2019; 28(8): 6268-74.
[60]
Kızıltaş H, Gören AC, Bingöl Z, Alwasel SH, Gülçin İ. Anticholinergic, antidiabetic and antioxidant activities of Ferula orientalis L. determination of its polyphenol contents by LC-HRMS. Rec Nat Prod 2021; 15(6): 315-28.
[61]
Sattar Z, Iranshahi M. Phytochemistry and pharmacology of Ferula persica Boiss.: A review. Iran J Basic Med Sci 2017; 20(1): 1-8.
[PMID: 28133517]
[62]
Hamdan II, Afifi FU. Studies on the in vitro and in vivo hypoglycemic activities of some medicinal plants used in treatment of diabetes in Jordanian traditional medicine. J Ethnopharmacol 2004; 93(1): 117-21.
[http://dx.doi.org/10.1016/j.jep.2004.03.033] [PMID: 15182916]
[63]
Akhzari D, Saadatfar A. Growth, phytoremediation potency and essential oil component of Ferula haussknechtii H. Wolff ex Rech. F. grown under lead stress conditions. J Rangel Sci 2019; 9(4): 392-401.
[64]
Zarei MA. Alpha-Glucosidase inhibitory activity in hexane extracts of some plants from kurdistan province. Faslnamah-i Giyahan-i Daruyi 2016; 15(58): 120-33.
[65]
Zarei M, Ghafaryan H. Alfa-Glucosidase inhibitory and antioxidant activity of hexane extract of flowers, leave and stems of Haplophyllum acutifolium DC. and Ferula haussknechtii Wolff ex Rech. Int J Adv Biol Biomed Res 2020; 8(2): 153-64.
[http://dx.doi.org/10.33945/SAMI/IJABBR.2020.2.6]

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