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Systematic Review Article

食用藜麦（藜麦）会改善血糖、体重和体重指数吗？临床试验的系统评价和剂量反应荟萃分析

卷 31, 期 4, 2024

发表于: 30 March, 2023

页: [502 - 513] 页: 12

弟呕挨: 10.2174/0929867330666230227151852

价格: $65

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摘要

背景：藜麦（Chenopodium quinoa）具有与全谷物相似的结构，含有植物化学物质和膳食纤维。因此，它被认为是一种具有高营养价值的食品。 目的：本研究的目的是通过随机临床试验的荟萃分析来评估藜麦在降低空腹血糖（FBG）、体重（BW）和体重指数（BMI）方面的功效。 方法：截至 2022 年 11 月，我们在 ISI Web of Science、Scopus 和 PubMed 数据库以及 Google Scholar 中进行了全面搜索，以找出研究藜麦对 FBG、BW 和 BMI 影响的随机临床试验的报告。 结果：本综述纳入了 7 项试验，涉及 258 名平均年龄为 31 至 64 岁的成年人。研究使用每天 15 至 50 克藜麦作为干预措施，干预时间为 28 至 180 天。在 FBG 的剂量反应分析中，有显着证据表明基于二次模型的干预与 FBG 之间存在非线性关联（非线性 P 值 = 0.027）；因此，当藜麦摄入量接近 25 克/天时，曲线斜率增加。比较藜麦籽补充剂和安慰剂，我们的研究结果表明，藜麦籽补充剂对 BMI (MD: -0.25; 95% CI: -0.98, 0.47; I2=0%, P = 0.998) 和 BW 没有显着影响与安慰剂相比（MD：-0.54；95% CI：-3.05, 1.97；I2=0%，P = 0.99）。纳入的研究中未发现发表偏倚的证据。 结论：本分析揭示了藜麦对血糖水平的有益影响。需要对藜麦进行进一步的研究来证实这些结果。

关键词: 藜麦，血糖水平，体重指数，体重，营养价值高，空腹血糖。

« Previous
[1]
Behloul, N.; Wu, G. Genistein: A promising therapeutic agent for obesity and diabetes treatment. Eur. J. Pharmacol., 2013, 698(1-3), 31-38.
[http://dx.doi.org/10.1016/j.ejphar.2012.11.013] [PMID: 23178528]
[2]
Astrup, A; Finer, N. Redefining type 2 diabetes:‘Diabesity’or ‘obesity dependent diabetes mellitus’? Obes Rev, 2000, 1(2), 57-59.
[http://dx.doi.org/10.1046/j.1467-789x.2000.00013.x] [PMID: 12119987]
[3]
Noratto, G.D.; Murphy, K.; Chew, B.P. Quinoa intake reduces plasma and liver cholesterol, lessens obesity-associated inflammation, and helps to prevent hepatic steatosis in obese db/db mouse. Food Chem., 2019, 287, 107-114.
[http://dx.doi.org/10.1016/j.foodchem.2019.02.061] [PMID: 30857678]
[4]
Franks, PW; McCarthy, MI Exposing the exposures responsible for type 2 diabetes and obesity. Science, 2016, 354(6308), 69-73.
[http://dx.doi.org/10.1126/science.aaf5094]
[5]
Riccardi, G.; Capaldo, B.; Vaccaro, O. Functional foods in the management of obesity and type 2 diabetes. Curr. Opin. Clin. Nutr. Metab. Care, 2005, 8(6), 630-635.
[http://dx.doi.org/10.1097/01.mco.0000171126.98783.0c] [PMID: 16205464]
[6]
Navarro-Perez, D.; Radcliffe, J.; Tierney, A.; Jois, M. Quinoa seed lowers serum triglycerides in overweight and obese subjects: A dose- response randomized controlled clinical trial. Curr. Dev. Nutr., 2017, 1(9), e001321.
[http://dx.doi.org/10.3945/cdn.117.001321] [PMID: 29955719]
[7]
Ando, H.; Chen, Y.C.; Tang, H.; Shimizu, M.; Watanabe, K.; Mitsunaga, T. Food components in fractions of quinoa seed. Food Sci. Technol. Res., 2002, 8(1), 80-84.
[http://dx.doi.org/10.3136/fstr.8.80]
[8]
Konishi, Y.; Hirano, S.; Tsuboi, H.; Wada, M. Distribution of minerals in quinoa (Chenopodium quinoa Willd.) seeds. Biosci. Biotechnol. Biochem., 2004, 68(1), 231-234.
[http://dx.doi.org/10.1271/bbb.68.231] [PMID: 14745190]
[9]
Bhargava, A.; Shukla, S.; Ohri, D. Chenopodium quinoa—An Indian perspective. Ind. Crops Prod., 2006, 23(1), 73-87.
[http://dx.doi.org/10.1016/j.indcrop.2005.04.002]
[10]
Alvarez-Jubete, L; Arendt, EK; Gallagher, E Nutritive value and chemical composition of pseudocereals as gluten-free ingredients. Int. J. Food Sci. Nutr., 2009, 60(S4), 240-257.
[http://dx.doi.org/10.1080/09637480902950597]
[11]
Tang, Y.; Li, X.; Zhang, B.; Chen, P.X.; Liu, R.; Tsao, R. Characterisation of phenolics, betanins and antioxidant activities in seeds of three Chenopodium quinoa willd. genotypes. Food Chem., 2015, 166, 380-388.
[http://dx.doi.org/10.1016/j.foodchem.2014.06.018] [PMID: 25053071]
[12]
Abugoch, J.L.E. Quinoa (Chenopodium quinoa Willd.): Composition, chemistry, nutritional, and functional properties. Adv. Food Nutr. Res., 2009, 58, 1-31.
[http://dx.doi.org/10.1016/S1043-4526(09)58001-1] [PMID: 19878856]
[13]
Navruz-Varli, S.; Sanlier, N. Nutritional and health benefits of quinoa (Chenopodium quinoa Willd.). J. Cereal Sci., 2016, 69, 371-376.
[http://dx.doi.org/10.1016/j.jcs.2016.05.004]
[14]
Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D.G.; Group, P. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med., 2009, 6(7), e1000097.
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[15]
Higgins, J.P.T. Cochrane handbook for systematic reviews of interventions version 5.0. 1. The Cochrane Collaboration. 2008. Available from:http://www cochrane-handbook
[16]
Crippa, A.; Discacciati, A.; Bottai, M.; Spiegelman, D.; Orsini, N. One-stage dose–response meta-analysis for aggregated data. Stat. Methods Med. Res., 2019, 28(5), 1579-1596.
[http://dx.doi.org/10.1177/0962280218773122] [PMID: 29742975]
[17]
Orsini, N.; Li, R.; Wolk, A.; Khudyakov, P.; Spiegelman, D. Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software. Am. J. Epidemiol., 2012, 175(1), 66-73.
[http://dx.doi.org/10.1093/aje/kwr265] [PMID: 22135359]
[18]
Abellán, R.M.S.; Barnuevo, E.M.D.; García, S.C.; Contreras, F.C.J.; Aldeguer, G.M.; Soto, M.F.; Guillén, G.I.; Luque, R.A.J.; Quinde, R.F.J.; Martínez, G.A.; López, R.F.J. [Effect of quinua (Chenopodium quinoa)consumption as a coadjuvant in nutritional intervention in prediabetic subjects]. Nutr. Hosp., 2017, 34(5), 1163-1169.
[PMID: 29130716]
[19]
De Carvalho, F.G.; Ovídio, P.P.; Padovan, G.J.; Jordão Junior, A.A.; Marchini, J.S.; Navarro, A.M. Metabolic parameters of postmenopausal women after quinoa or corn flakes intake – a prospective and double-blind study. Int. J. Food Sci. Nutr., 2014, 65(3), 380-385.
[http://dx.doi.org/10.3109/09637486.2013.866637] [PMID: 24344670]
[20]
Farinazzi-Machado, F.M.V.; Barbalho, S.M.; Oshiiwa, M.; Goulart, R.; Pessan, J.O. Use of cereal bars with quinoa (Chenopodium quinoa W.) to reduce risk factors related to cardiovascular diseases. Food Sci. Technol., 2012, 32(2), 239-244.
[http://dx.doi.org/10.1590/S0101-20612012005000040]
[21]
Li, L.; Lietz, G.; Bal, W.; Watson, A.; Morfey, B.; Seal, C. Effects of quinoa (Chenopodium quinoa Willd.) consumption on markers of CVD risk. Nutrients, 2018, 10(6), 777.
[http://dx.doi.org/10.3390/nu10060777] [PMID: 29914146]
[22]
Pourshahidi, L.K.; Caballero, E.; Osses, A.; Hyland, B.W.; Ternan, N.G.; Gill, C.I.R. Modest improvement in CVD risk markers in older adults following quinoa (Chenopodium quinoa Willd.) consumption: A randomized-controlled crossover study with a novel food product. Eur. J. Nutr., 2020, 59(7), 3313-3323.
[http://dx.doi.org/10.1007/s00394-019-02169-0] [PMID: 31919583]
[23]
Oliveira, S.V.; Lima, G.M.; Fernando, V.D.; Fernandes de, G.M. Effects of intake of processed quinoa seeds on lipid profile in patients with coronary heart disease. Int. J. Sci., 2018, 4(3), 8-14.
[http://dx.doi.org/10.18483/ijSci.1572]
[24]
Karimian, J.; Abedi, S.; Shirinbakhshmasoleh, M.; Moodi, F.; Moodi, V.; Ghavami, A. The effects of quinoa seed supplementation on cardiovascular risk factors: A systematic review and meta-analysis of controlled clinical trials. Phytother. Res., 2020, 35(4), 1688-1696.
[http://dx.doi.org/10.1002/ptr.6901] [PMID: 33037704]
[25]
Vilcacundo, R.; Hernández-Ledesma, B. Nutritional and biological value of quinoa (Chenopodium quinoa Willd.). Curr. Opin. Food Sci., 2017, 14, 1-6.
[http://dx.doi.org/10.1016/j.cofs.2016.11.007]
[26]
Alvarez-Jubete, L.; Arendt, E.K.; Gallagher, E. Nutritive value of pseudocereals and their increasing use as functional gluten-free ingredients. Trends Food Sci. Technol., 2010, 21(2), 106-113.
[http://dx.doi.org/10.1016/j.tifs.2009.10.014]
[27]
Hernández, R.J. Quinoa, an option for feeding of the diabetes mellitus patient. Rev. Cuba. Endocrinol., 2015, 26(3), 304-312.
[28]
Lamothe, L.M.; Srichuwong, S.; Reuhs, B.L.; Hamaker, B.R. Quinoa (Chenopodium quinoa W.) and amaranth (Amaranthus caudatus L.) provide dietary fibres high in pectic substances and xyloglucans. Food Chem., 2015, 167, 490-496.
[http://dx.doi.org/10.1016/j.foodchem.2014.07.022] [PMID: 25149016]
[29]
Tang, Y.; Tsao, R. Phytochemicals in quinoa and amaranth grains and their antioxidant, anti-inflammatory, and potential health beneficial effects: a review. Mol. Nutr. Food Res., 2017, 61(7), 1600767.
[http://dx.doi.org/10.1002/mnfr.201600767] [PMID: 28239982]
[30]
Foucault, A.S.; Mathé, V.; Lafont, R.; Even, P.; Dioh, W.; Veillet, S.; Tomé, D.; Huneau, J.F.; Hermier, D.; Quignard-Boulangé, A. Quinoa extract enriched in 20-hydroxyecdysone protects mice from diet-induced obesity and modulates adipokines expression. Obesity, 2012, 20(2), 270-277.
[http://dx.doi.org/10.1038/oby.2011.257] [PMID: 21869758]
[31]
Mithila, M.V.; Khanum, F. Effectual comparison of quinoa and amaranth supplemented diets in controlling appetite; a biochemical study in rats. J. Food Sci. Technol., 2015, 52(10), 6735-6741.
[http://dx.doi.org/10.1007/s13197-014-1691-1] [PMID: 26396423]

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