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奥替康唑:首个被批准用于治疗复发性外阴阴道念珠菌病的口服生物可利用选择性CYP51抑制剂

卷 30, 期 37, 2023

发表于: 03 March, 2023

页: [4170 - 4175] 页: 6

弟呕挨: 10.2174/0929867330666230220130024

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摘要

奥特斯康唑于2022年4月获得美国FDA批准。它是第一个被批准用于治疗复发性外阴阴道念珠菌病的选择性和口服生物可利用的CYP51抑制剂。在此，我们描述了它的剂量，给药，化学结构，物理性质，合成，作用机制和药代动力学。

关键词: 抗真菌药物，作用机制，真菌羊毛甾醇去甲基酶，阴道炎，甾醇生物合成，奥替康唑。

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