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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Targeting Ion Channels for the Treatment of Glioma

Author(s): Saritha Keluth, Srikanth Jitte, Rashmi Bhushan, Om Prakash Ranjan, Krishna Murti, Velayutham Ravichandiran and Nitesh Kumar*

Volume 23, Issue 12, 2023

Published on: 09 March, 2023

Page: [1298 - 1318] Pages: 21

DOI: 10.2174/1389557523666230210150120

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Abstract

Background: Glioma refers to the most aggressive tumor in the central nervous system that starts from support cells or glial cells. The glial cell is the most common cell type in the CNS, and they insulate, surround, as well as feed, oxygen, and nutrition to the neurons. Seizures, headaches, irritability, vision difficulties, and weakness are some of the symptoms. Targeting ion channels is particularly helpful when it comes to glioma treatment because of their substantial activity in glioma genesis through multiple pathways.

Objective: In this study, we explore how distinct ion channels can be targeted for glioma treatment and summarize the pathogenic ion channels activity in gliomas.

Results: Current research found several side effects such as bone marrow suppression, alopecia, insomnia, and cognitive impairments for presently done chemotherapy. The involvement of research on ion channels in the regulation of cellular biology and towards improvements of glioma have expanded recognition of their innovative roles.

Conclusion: Present review article has expanded knowledge of ion channels as therapeutic targets and detailed cellular mechanisms in the roles of ion channels in gliomas pathogenesis.

Keywords: Gliomas, ion channels, calcium channel, potassium channel, CNS, epigenetic regulation, therapeutic targets, brain tumors.

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