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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

含有5-氟尿嘧啶的聚己内酯纳米载体作为增强抗癌活性的治疗引导药物递送方法

卷 23, 期 7, 2023

发表于: 21 March, 2023

页: [524 - 533] 页: 10

弟呕挨: 10.2174/1568009623666230210140212

价格: $65

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摘要

如今，为药物输送系统（DDS）设计的纳米平台，如聚合物、脂质体和胶束，已被证明具有临床效率。持续药物释放是DDS的优势之一，尤其是基于聚合物的纳米颗粒。该配方可以增强药物的耐久性，其中可生物降解的聚合物是DDS最有趣的构建单元。 纳米载体可以通过某些内化途径（如细胞内吞作用途径和增加生物相容性）局部药物递送和释放来规避许多问题。聚合物纳米颗粒及其纳米复合材料是最重要的一类材料之一，可用于组装可以形成复杂、共轭和封装形式的纳米载体。位点特异性药物递送可能来自纳米载体通过生物屏障的能力、它们与受体的特异性相互作用以及被动靶向。更好的循环、摄取和稳定性以及靶向属性导致更少的副作用和对正常细胞的损害。因此，本文介绍了聚己内酯基或改性纳米颗粒在5-氟尿嘧啶（5-FU）药物递送系统（DDS）中的最新成果。

关键词: 聚己内酯，癌症，药物递送，5-氟尿嘧啶，聚合物纳米颗粒，药物释放。

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