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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Research Progress on Antiviral Activity of Heparin

Author(s): Yi Wang, Yanqing Zhang, Ping Wang*, Tianyuan Jing, Yanan Hu and Xiushan Chen

Volume 31, Issue 1, 2024

Published on: 09 March, 2023

Page: [7 - 24] Pages: 18

DOI: 10.2174/0929867330666230203124032

Price: $65

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Abstract

Heparin, as a glycosaminoglycan, is known for its anticoagulant and antithrombotic properties for several decades. Heparin is a life-saving drug and is widely used for anticoagulation in medical practice. In recent years, there have been extensive studies that heparin plays an important role in non-anticoagulant diseases, such as anti-inflammatory, anti-viral, anti-angiogenesis, anti-neoplastic, anti-metastatic effects, and so on. Clinical observation and in vitro experiments indicate that heparin displays a potential multitarget effect. In this brief review, we will summarize heparin and its derivative's recently studied progress for the treatment of various viral infections. The aim is to maximize the benefits of drugs through medically targeted development, to meet the unmet clinical needs of serious viral diseases.

Keywords: Heparin, heparan sulfate, antiviral, heparin mimic, mechanism, virus, glycosaminoglycan.

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