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Current Medicinal Chemistry

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Review Article

Cognitive Benefits of Sodium-Glucose Co-Transporters-2 Inhibitors in the Diabetic Milieu

Author(s): Habib Yaribeygi*, Mina Maleki, Thozhukat Sathyapalan*, Manfredi Rizzo and Amirhossein Sahebkar*

Volume 31, Issue 2, 2024

Published on: 20 March, 2023

Page: [138 - 151] Pages: 14

DOI: 10.2174/0929867330666230202163513

Price: $65

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Abstract

Patients with diabetes are at higher risk of cognitive impairment and memory loss than the normal population. Thus, using hypoglycemic agents to improve brain function is important for diabetic patients. Sodium-glucose cotransporters-2 inhibitors (SGLT2i) are a class of therapeutic agents used in the management of diabetes that has some pharmacologic effects enabling them to fight against the onset and progress of memory deficits. Although the exact mediating pathways are not well understood, emerging evidence suggests that SGLT2 inhibition is associated with improved brain function. This study reviewed the possible mechanisms and provided evidence suggesting SGLT2 inhibitors could ameliorate cognitive deficits.

Keywords: Diabetes mellitus, sodium-glucose cotransporters-2 inhibitors, oxidative stress, apoptosis, cognition, memory.

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