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Review Article

LncRNA:动脉粥样硬化的重要调节因子

卷 30, 期 38, 2023

发表于: 02 February, 2023

页: [4340 - 4354] 页: 15

弟呕挨: 10.2174/0929867330666230111125141

价格: $65

Open Access Journals Promotions 2
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摘要

长链非编码RNA (Long non-coding RNA, lncRNA)是一类调节细胞增殖、凋亡、分化、衰老、机体发育等重要生命活动的生物分子。研究发现lncrna与多种疾病密切相关。在心血管疾病中，lncRNAs影响动脉粥样硬化斑块中相关基因的表达水平，这些基因与内皮功能障碍、平滑肌细胞增殖、巨噬细胞功能障碍、脂质代谢异常、细胞自噬等密切相关，参与调节AS的发生发展。鉴于此，研究lncRNAs在心血管系统疾病中调控心脏基因网络的作用已引起临床的广泛关注，并可能成为AS治疗的新靶点。本文将重点关注与AS相关的lncRNAs，探讨lncRNAs与AS的关系，提出lncRNAs在AS的预防和治疗中的作用，并期待更多的lncRNAs作为标志物应用于临床AS的诊断和治疗。

关键词: lncrna，动脉粥样硬化，ceRNA，生物标志物，预后，药物发现。

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