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Review Article

最新的纳米载体治疗阿尔茨海默病:当前的策略和观点

卷 30, 期 33, 2023

发表于: 28 December, 2022

页: [3743 - 3774] 页: 32

弟呕挨: 10.2174/0929867330666221115103513

价格: $65

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摘要

本文综述了解决与阿尔茨海默病(AD)相关的全球性问题的纳米治疗策略。造成这种情况在人文、社会和经济方面的紧迫性的最显著因素是这种疾病的不可治愈性，药物干预只能解决阿尔茨海默病的症状并延缓其进展。这些挑战背后的主要原因是无法早期诊断AD，缺乏关于发病机制的分子机制的全面信息，血脑屏障障碍，以及现有药物和治疗策略的有效性不足。纳米载体的应用可以部分解决这些问题，同时提高药物的生物利用度，延长循环时间，克服/绕过生物屏障。迄今为止，许多类型和亚型的纳米载体被开发和审查，其中大多数可以用于治疗各种疾病。因此，本文根据AD药物的给药途径对纳米治疗策略进行了具体分类，强调了非侵入性，即透皮、口服和鼻内给药途径。此外，还讨论了各种纳米载体的优点和局限性，并对其应用前景进行了展望。

关键词: 阿尔茨海默病，药物传递，纳米治疗策略，给药途径，脂质配方，聚合物纳米载体。

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