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Review Article

Melanocortin Receptors: Emerging Targets for the Treatment of Pigmentation, Inflammation, Stress, Weight Disorders and Sexual Dysfunction

Author(s): Miteshkumar Rajaram Maurya*, Renuka Munshi and Sachin Zambare

Volume 24, Issue 2, 2023

Published on: 25 November, 2022

Page: [151 - 156] Pages: 6

DOI: 10.2174/1389450124666221108143006

Price: $65

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Abstract

Melanocortins are tiny protein molecules formed by the post-translational cleavage of proopiomelanocortin. These are bioactive peptides that are responsible for human and lower animal pigmentation patterns, energy homeostasis, and sexual function modulation. These peptides regulate numerous physiological functions by being generated in the central nervous system and peripheral tissues. Melanocortins elicit their varied biological effects by binding to a separate family of G protein, two primary proteolytic enzymes, proconvertases 1 and 2, according to recent research. These breakthroughs have opened up new avenues for research into the role of melanocortins, antagonists, and receptors in a number of physiological activities.

Keywords: Melanocortin receptors, agouti related peptide, proopiomelanocortin, melanotans, pigmentation treatment, melanin.

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