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Review Article

基于金属螯合剂的阿尔茨海默病多靶点协同治疗研究

卷 24, 期 2, 2023

发表于: 27 October, 2022

页: [131 - 150] 页: 20

弟呕挨: 10.2174/1389450123666220926143920

价格: $65

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摘要

阿尔茨海默病(AD)己成为世界第四大死因。由于其复发的发病机制，目前仍缺乏有效的药物治疗。研究发配，金属稳态失调与氧化应激、β-淀粉样蛋白沉积等AD的其他发病机制密切相关。因此，寻找合适的金属螯合剂来调节金属稳态就成为重要的靶点。同时，由于发病机制复杂，单一靶点药物无法取得良好效果果。因此，目前的研究主要集中在探索AD的多靶点治疗。本文就基于金属螯合剂和其他靶点的多靶点协同抗AD研究进行综述。总结了不同螯合剂的结构特点，分析了其构效关系，为后续基于金属螯合剂的抗AD多靶点药物的开发提供了一些有价值的线索。

关键词: 多靶点，阿尔茨海默病，金属稳态，金属螯合剂，协同治疗，氧化应激

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