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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin

Author(s): Eka Noviana*, Soni Siswanto and Agustina Ari Murti Budi Hastuti

Volume 22, Issue 27, 2022

Published on: 03 October, 2022

Page: [2261 - 2281] Pages: 21

DOI: 10.2174/1568026622666220915114646

Price: $65

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Abstract

Diabetes is a major public health burden whose prevalence has been steadily increasing over the past decades. Glycated hemoglobin (HbA1c) is currently the gold standard for diagnostics and monitoring of glycemic control in diabetes patients. HbA1c biosensors are often considered to be cost-effective alternatives for smaller testing laboratories or clinics unable to access other reference methods. Many of these sensors deploy nanomaterials as recognition elements, detection labels, and/or transducers for achieving sensitive and selective detection of HbA1c. Nanomaterials have emerged as important sensor components due to their excellent optical and electrical properties, tunable morphologies, and easy integration into multiple sensing platforms. In this review, we discuss the advantages of using nanomaterials to construct HbA1c sensors and various sensing strategies for HbA1c measurements. Key gaps between the current technologies with what is needed moving forward are also summarized.

Keywords: Biosensors, Glycated hemoglobin, HbA1c, Nanomaterials, Nanosensors, Tunable morphologies.

Graphical Abstract
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