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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Review Article

Anti-cancer Potential of Hypericum spp. with Focus on Hypericum Perforatum: A Review of the Literature

Author(s): Seyyed Mohammad Matin Alavi Dana, Maryam Khoshnazar, Shabnam Paydari Banyarani, Farzin Sataei Mokhtari, Zahra Eslami Mohammadie, Amirreza Shamsehkohan, Maryam Valizadeh, Ramin Ahangar-Sirous, Zahra Rahimi, Mohadeseh Poudineh and Niloofar Deravi*

Volume 9, Issue 4, 2023

Published on: 12 October, 2022

Article ID: e220822207861 Pages: 18

DOI: 10.2174/2215083808666220822141221

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Abstract

Background and Aims: Cancer is the cause of many deaths and is the second most prevalent cause of death worldwide. Besides its high mortality, cancer can cause emotional and economic burdens on patients and society. Hypericum is known as herbal medicine that has many species. Its anticancer effects have been proven in various articles. It has many active compounds, including flavonoids, phloroglucinols, and phenylpropanoids. The current review aimed to collect data on the anticancer potential of Hypericum on different types of cancer cell lines and their chief mechanisms.

Methods: A search was conducted on PubMed, Scopus, Web of Science, ScienceDirect, ResearchGate, and Google Scholar databases to find relevant studies on the anti-cancer potential of Hypericum perforatum and its underlying mechanisms of action in different cancers. The relevant English language articles published up to March 2022 were collected, screened, and reviewed.

Results: The anti-cancer effects of Hypericum perforatum were shown against glioblastoma, neuroblastoma, leukemia, and liver, breast, prostate, lung, bladder, colon, skin, and pancreatic cancers. It can induce apoptosis by activating caspase enzymes and inhibit cell growth in different cancer cell lines. Also, the cytotoxic effects of Hypericum perforatum extract on cancer cell lines were shown in in vitro studies.

Conclusion: Hypericum perforatum can be proposed as a strong herbal remedy for the treatment of cancer since it is an available and cheap treatment for cancer compared to other treatments, but further clinical trial studies should be performed to confirm these properties.

Keywords: Hypericum, St John's-wort, anti-cancer, herbal medicine, death, cancer.

[1]
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015; 65(2): 87-108.
[http://dx.doi.org/10.3322/caac.21262] [PMID: 25651787]
[2]
Massie MJ. Prevalence of depression in patients with cancer. J Natl Cancer Inst Monogr 2004; 2004(32): 57-71.
[http://dx.doi.org/10.1093/jncimonographs/lgh014] [PMID: 15263042]
[3]
Heer E, Harper A, Escandor N, Sung H, McCormack V, Fidler-Benaoudia MM. Global burden and trends in premenopausal and postmenopausal breast cancer: A population-based study. Lancet Glob Health 2020; 8(8): e1027-37.
[http://dx.doi.org/10.1016/S2214-109X(20)30215-1] [PMID: 32710860]
[4]
Aljeboory AAH, Al-Zubaidi NMA. Loranthus Europaeus is an alternative medicine in treatment of cyst and mouth inflammation resulted from chemotherapy of breast cancer. Int J Drug Delivery Technol 2020; 10(1): 183-6.
[http://dx.doi.org/10.25258/ijddt.10.1.32]
[5]
Bookland MJ, Darbinian N, Weaver M, Amini S, Khalili K. Growth inhibition of malignant glioblastoma by DING protein. J Neurooncol 2012; 107(2): 247-56.
[http://dx.doi.org/10.1007/s11060-011-0743-x] [PMID: 22052333]
[6]
Agnelli G, George DJ, Kakkar AK, et al. Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer. N Engl J Med 2012; 366(7): 601-9.
[http://dx.doi.org/10.1056/NEJMoa1108898] [PMID: 22335737]
[7]
Oh J, Kutas GJ, Davey P, Morrison M, Perry JR. Aplastic anemia with concurrent temozolomide treatment in a patient with glioblastoma multiforme. Curr Oncol 2010; 17(4): 124-6.
[http://dx.doi.org/10.3747/co.v17i4.526] [PMID: 20697524]
[8]
Marrelli M, Statti G, Conforti F, Menichini F. New potential pharmaceutical applications of Hypericum species. Mini Rev Med Chem 2016; 16(9): 710-20.
[http://dx.doi.org/10.2174/1389557515666150709105844] [PMID: 26156546]
[9]
Perrut M. Sterilization and virus inactivation by supercritical fluids (a review). J Supercrit Fluids 2012; 66: 359-71.
[http://dx.doi.org/10.1016/j.supflu.2011.07.007]
[10]
Rizzo P, Altschmied L, Ravindran BM, Rutten T, D’Auria JC. The biochemical and genetic basis for the biosynthesis of bioactive compounds in Hypericum perforatum L., one of the largest medicinal crops in Europe. Genes (Basel) 2020; 11(10): 1210.
[http://dx.doi.org/10.3390/genes11101210] [PMID: 33081197]
[11]
Miskovsky P. Hypericin--a new antiviral and antitumor photosensitizer: Mechanism of action and interaction with biological macromolecules. Curr Drug Targets 2002; 3(1): 55-84.
[http://dx.doi.org/10.2174/1389450023348091] [PMID: 11899265]
[12]
Kim SJ, Um JY, Hong S-H, Lee JY. Anti-inflammatory activity of hyperoside through the suppression of nuclear factor-κB activation in mouse peritoneal macrophages. Am J Chin Med 2011; 39(1): 171-81.
[http://dx.doi.org/10.1142/S0192415X11008737] [PMID: 21213407]
[13]
Guon TE, Chung HS. Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells. Oncol Lett 2016; 11(4): 2463-70.
[http://dx.doi.org/10.3892/ol.2016.4247] [PMID: 27073499]
[14]
Chen W-T, Chen Y-K, Lin S-S, Hsu F-T. Hyperforin suppresses tumor growth and NF-κB-mediated anti-apoptotic and invasive potential of non-small cell lung cancer. Anticancer Res 2018; 38(4): 2161-7.
[PMID: 29599335]
[15]
Kopustinskiene DM, Jakstas V, Savickas A, Bernatoniene J. Flavonoids as anticancer agents. Nutrients 2020; 12(2): 457.
[http://dx.doi.org/10.3390/nu12020457] [PMID: 32059369]
[16]
Imani A, Maleki N, Bohlouli S, Kouhsoltani M, Sharifi S, Maleki Dizaj S. Molecular mechanisms of anticancer effect of rutin. Phytother Res 2021; 35(5): 2500-13.
[http://dx.doi.org/10.1002/ptr.6977] [PMID: 33295678]
[17]
Cai Y, Zhang J, Chen NG, et al. Recent advances in anticancer activities and drug delivery systems of tannins. Med Res Rev 2017; 37(4): 665-701.
[http://dx.doi.org/10.1002/med.21422] [PMID: 28004409]
[18]
Bradshaw A, Wickremsekera A, Tan ST, Peng L, Davis PF, Itinteang T. Cancer stem cell hierarchy in glioblastoma multiforme. Front Surg 2016; 3: 21.
[http://dx.doi.org/10.3389/fsurg.2016.00021] [PMID: 27148537]
[19]
Borawska MH, Naliwajko SK, Moskwa J. Markiewicz-Żukowska R, Puścion-Jakubik A, Soroczyńska J. Anti-proliferative and anti-migration effects of Polish propolis combined with Hypericum perforatum L. on glioblastoma multiforme cell line U87MG. BMC Complement Altern Med 2016; 16(1): 367.
[http://dx.doi.org/10.1186/s12906-016-1351-2] [PMID: 27647142]
[20]
Keksel N, Bussmann H, Unger M, et al. St John’s wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells. Phytomedicine 2019; 54: 66-76.
[http://dx.doi.org/10.1016/j.phymed.2018.06.013] [PMID: 30668384]
[21]
Jakobs D, Hage-Hülsmann A, Prenner L, Kolb C, Weiser D, Häberlein H. Downregulation of β1-adrenergic receptors in rat C6 glioblastoma cells by hyperforin and hyperoside from St John’s wort. J Pharm Pharmacol 2013; 65(6): 907-15.
[http://dx.doi.org/10.1111/jphp.12050] [PMID: 23647684]
[22]
Mrozikiewicz PM, Bogacz A, Bartkowiak-Wieczorek J, et al. Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters. Acta Pharm 2014; 64(2): 223-32.
[http://dx.doi.org/10.2478/acph-2014-0020] [PMID: 24914722]
[23]
Franco P, Fiorentino A, Dionisi F, et al. Combined modality therapy for thoracic and head and neck cancers: A review of updated literature based on a consensus meeting. Tumori 2016; 102(5): 459-71.
[http://dx.doi.org/10.5301/tj.5000525] [PMID: 27514316]
[24]
Numico G, Franco P, Cristofano A, et al. Is the combination of Cetuximab with chemo-radiotherapy regimens worthwhile in the treatment of locally advanced head and neck cancer? A review of current evidence. Crit Rev Oncol Hematol 2013; 85(2): 112-20.
[http://dx.doi.org/10.1016/j.critrevonc.2012.05.005] [PMID: 22743346]
[25]
Rampino M, Ricardi U, Munoz F, et al. Concomitant adjuvant chemoradiotherapy with weekly low-dose cisplatin for high-risk squamous cell carcinoma of the head and neck: A phase II prospective trial. Clin Oncol (R Coll Radiol) 2011; 23(2): 134-40.
[http://dx.doi.org/10.1016/j.clon.2010.09.004] [PMID: 21030225]
[26]
Franco P, Potenza I, Moretto F, et al. Hypericum perforatum and neem oil for the management of acute skin toxicity in head and neck cancer patients undergoing radiation or chemo-radiation: A single-arm prospective observational study. Radiat Oncol 2014; 9(1): 297.
[http://dx.doi.org/10.1186/s13014-014-0297-0] [PMID: 25544371]
[27]
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61(2): 69-90.
[http://dx.doi.org/10.3322/caac.20107] [PMID: 21296855]
[28]
Dai LC, Wang X, Yao X, Lu Y-L, Ping J-L, He J-F. Enhanced therapeutic effects of combined chemotherapeutic drugs and midkine antisense oligonucleotides for hepatocellular carcinoma. World J Gastroenterol 2007; 13(13): 1989-94.
[http://dx.doi.org/10.3748/wjg.v13.i13.1989] [PMID: 17461503]
[29]
Zhang HB, Lu P, Cao WB, Zhang ZH, Meng XL. The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy. Mol Clin Oncol 2013; 1(2): 395-9.
[http://dx.doi.org/10.3892/mco.2012.52] [PMID: 24649182]
[30]
Zhuang Q, Li J, Chen Y, et al. Ethyl acetate extract of Hypericum japonicum induces apoptosis via the mitochondria-dependent pathway in vivo and in vitro. Mol Med Rep 2015; 12(4): 4851-8.
[http://dx.doi.org/10.3892/mmr.2015.4086] [PMID: 26239512]
[31]
Ji Y, Zhang R, Zhang C, et al. Cytotoxic xanthones from Hypericum stellatum, an ethnomedicine in Southwest China. Molecules 2019; 24(19): 3568.
[http://dx.doi.org/10.3390/molecules24193568] [PMID: 31581734]
[32]
Shiono Y, Shiono N, Seo S, Oka S, Yamazaki Y. Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Z Naturforsch C J Biosci 2002; 57(9-10): 923-9.
[http://dx.doi.org/10.1515/znc-2002-9-1028] [PMID: 12440735]
[33]
Ferguson A, Morris C, Curley J. Hypericum perforatum extracts and hypericin treatment of a mouse mammary cancer cell line induces growth inhibition in a dose dependent manner. J Exp Second Sci 2011; 3: 14-8.
[34]
Barani M, Sabir F, Rahdar A, Arshad R, Kyzas GZ. Nanotreatment and nanodiagnosis of prostate cancer: Recent updates. Nanomaterials (Basel) 2020; 10(9): 1696.
[http://dx.doi.org/10.3390/nano10091696] [PMID: 32872181]
[35]
Abrahamsson PA. Neuroendocrine cells in tumour growth of the prostate. Endocr Relat Cancer 1999; 6(4): 503-19.
[http://dx.doi.org/10.1677/erc.0.0060503] [PMID: 10730904]
[36]
Di Sant’Agnese PA. Neuroendocrine differentiation in carcinoma of the prostate. Diagnostic, prognostic, and therapeutic implications. Cancer 1992; 70(S1) (Suppl.): 254-68.
[http://dx.doi.org/10.1002/1097-0142(19920701)70:1+<254:AID-CNCR2820701312>3.0.CO;2-E] [PMID: 1350941]
[37]
Abdul M, Logothetis CJ, Hoosein NM. Growth-inhibitory effects of serotonin uptake inhibitors on human prostate carcinoma cell lines. J Urol 1995; 154(1): 247-50.
[http://dx.doi.org/10.1016/S0022-5347(01)67288-4] [PMID: 7776439]
[38]
Abdul M, Anezinis PE, Logothetis CJ, Hoosein NM. Growth inhibition of human prostatic carcinoma cell lines by serotonin antagonists. Anticancer Res 1994; 14(3A): 1215-20.
[PMID: 8074475]
[39]
Martarelli D, Martarelli B, Pediconi D, Nabissi MI, Perfumi M, Pompei P. Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice. Cancer Lett 2004; 210(1): 27-33.
[http://dx.doi.org/10.1016/j.canlet.2004.01.031] [PMID: 15172117]
[40]
Pereira DM, Rodrigues PM, Borralho PM, Rodrigues CMP. Delivering the promise of miRNA cancer therapeutics. Drug Discov Today 2013; 18(5-6): 282-9.
[http://dx.doi.org/10.1016/j.drudis.2012.10.002] [PMID: 23064097]
[41]
Liang H, Zhang S, Fu Z, et al. Effective detection and quantification of dietetically absorbed plant microRNAs in human plasma. J Nutr Biochem 2015; 26(5): 505-12.
[http://dx.doi.org/10.1016/j.jnutbio.2014.12.002] [PMID: 25704478]
[42]
Galla G, Volpato M, Sharbel TF, Barcaccia G. Computational identification of conserved microRNAs and their putative targets in the Hypericum perforatum L. flower transcriptome. Plant Reprod 2013; 26(3): 209-29.
[http://dx.doi.org/10.1007/s00497-013-0227-6] [PMID: 23846415]
[43]
Ergün S. Cross-Kingdom Gene regulation via miRNAs of Hypericum perforatum (St. John’s wort) flower dietetically absorbed: An in silico approach to define potential biomarkers for prostate cancer. Comput Biol Chem 2019; 80: 16-22.
[http://dx.doi.org/10.1016/j.compbiolchem.2019.02.010] [PMID: 30861403]
[44]
de Koning HJ, van der Aalst CM, de Jong PA, et al. Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med 2020; 382(6): 503-13.
[http://dx.doi.org/10.1056/NEJMoa1911793] [PMID: 31995683]
[45]
Aztopal N, Erkisa M, Celikler S, Ulukaya E, Ari F. Antigrowth and apoptosis inducing effects of Hypericum olympicum L. and Hypericum adenotrichum Spach. on lung cancer cells in vitro: Involvement of DNA damage. J Food Biochem 2016; 40(4): 559-66.
[http://dx.doi.org/10.1111/jfbc.12248]
[46]
Elumalai K, Velmurugan S. Green synthesis, characterization and antimicrobial activities of zinc oxide nanoparticles from the leaf extract of Azadirachta indica (L.). Appl Surf Sci 2015; 345: 329-36.
[http://dx.doi.org/10.1016/j.apsusc.2015.03.176]
[47]
Al Sharie AH, El-Elimat T, Darweesh RS, et al. Green synthesis of zinc oxide nanoflowers using Hypericum triquetrifolium extract: Characterization, antibacterial activity and cytotoxicity against lung cancer A549 cells. Appl Organomet Chem 2020; 34(8): e5667.
[http://dx.doi.org/10.1002/aoc.5667]
[48]
Jang MH, Lee TH, Shin MC, et al. Protective effect of Hypericum perforatum Linn (St. John’s wort) against hydrogen peroxide-induced apoptosis on human neuroblastoma cells. Neurosci Lett 2002; 329(2): 177-80.
[http://dx.doi.org/10.1016/S0304-3940(02)00644-4] [PMID: 12165406]
[49]
Dongre SH, Badami S, Godavarthi A. Antitumor activity of Hypericum hookerianum against DLA induced tumor in mice and its possible mechanism of action. Phytother Res 2008; 22(1): 23-9.
[http://dx.doi.org/10.1002/ptr.2248] [PMID: 17674426]
[50]
Dongre SH, Badami S, Natesan S, Chandrashekhar RH. Antitumor activity of the methanol extract of Hypericum hookerianum stem against Ehrlich ascites carcinoma in Swiss albino mice. J Pharmacol Sci 2007; 103(4): 354-9.
[http://dx.doi.org/10.1254/jphs.FP0061088] [PMID: 17443057]
[51]
Puthur S, Anoopkumar AN, Rebello S, Aneesh EM. Hypericum japonicum: A double-headed sword to combat vector control and cancer. Appl Biochem Biotechnol 2018; 186(1): 1-11.
[http://dx.doi.org/10.1007/s12010-018-2713-7] [PMID: 29476319]
[52]
Mirmalek SA, Hajilou M, Salimi Tabatabaee SA, Parsa Y, Yadollah-Damavandi S, Parsa T. Prevalence of HER-2 and hormone receptors and P53 mutations in the pathologic specimens of breast cancer patients. Int J Breast Cancer 2014; 2014: 564308.
[53]
Momekov G, Ferdinandov D, Zheleva-Dimitrova D, Nedialkov P, Girreser U, Kitanov G. Cytotoxic effects of hyperatomarin, a prenylated phloroglucinol from Hypericum annulatum Moris subsp. annulatum, in a panel of malignant cell lines. Phytomedicine 2008; 15(11): 1010-5.
[http://dx.doi.org/10.1016/j.phymed.2008.04.008] [PMID: 18539018]
[54]
Schempp CM, Kirkin V, Simon-Haarhaus B, et al. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John’s wort that acts by induction of apoptosis. Oncogene 2002; 21(8): 1242-50.
[http://dx.doi.org/10.1038/sj.onc.1205190] [PMID: 11850844]
[55]
Mirmalek SA, Azizi MA, Jangholi E, et al. Cytotoxic and apoptogenic effect of hypericin, the bioactive component of Hypericum perforatum on the MCF-7 human breast cancer cell line. Cancer Cell Int 2015; 16(1): 3.
[http://dx.doi.org/10.1186/s12935-016-0279-4] [PMID: 26865836]
[56]
Sarimahmut M, Balikci N, Celikler S, et al. Evaluation of genotoxic and apoptotic potential of Hypericum adenotrichum Spach. in vitro. Regul Toxicol Pharmacol 2016; 74: 137-46.
[http://dx.doi.org/10.1016/j.yrtph.2015.11.010] [PMID: 26617407]
[57]
Aydemi̇r I, Ozkan O, Savran A. The effects of Hypericum crenulatum polysaccharides on the proliferation of cancer cells. Aegean J Med Sci 2020; 3(1): 1-6.
[58]
Balikci N, Sarimahmut M, Ari F, et al. Toxicity assessment of Hypericum olympicum subsp. olympicum L. on human lymphocytes and breast cancer cell lines. J Appl Biomed 2020; 18(1): 18-25.
[59]
Eghdami A, Piri H, Sirati-Sabet M, Ilghari D. Investigation of anti proliferative properties and antioxidant activity of aerial parts ethanolic extract of Hypericum perforatum L. by breast cancer 4T1 cell lines. Int J Biosci 2013; 3(12): 265-72.
[http://dx.doi.org/10.12692/ijb/3.12.265-272]
[60]
Harun A, Tutun H, Kaplan HM. Şingirik E, Altintaş L. Investigation of apoptotic effects of Hypericum perforatum extract on breast cancer cell line. Harran Üniversitesi Veteriner Fakültesi Dergisi 2019; 8(2): 198-202.
[61]
Deveci HA. Nazıroğlu M, Nur G. 5-Fluorouracil-induced mitochondrial oxidative cytotoxicity and apoptosis are increased in MCF-7 human breast cancer cells by TRPV1 channel activation but not Hypericum perforatum treatment. Mol Cell Biochem 2018; 439(1-2): 189-98.
[http://dx.doi.org/10.1007/s11010-017-3147-1] [PMID: 28795251]
[62]
You MK, Kim HJ, Kook J, Kim HA. John’s wort regulates proliferation and apoptosis in MCF-7 human breast cancer cells by inhibiting AMPK/mTOR and activating the mitochondrial pathway. Int J Mol Sci 2018; 19(4): 966.
[http://dx.doi.org/10.3390/ijms19040966] [PMID: 29570671]
[63]
Oh, S, e X, Ni D, et al. Downregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis. Cell Death Differ 2011; 18(3): 452-64.
[http://dx.doi.org/10.1038/cdd.2010.116] [PMID: 20885445]
[64]
You M, Lee YH, Kim HJ, Kook JH, Kim HASt. John’s wort suppresses growth in triple-negative breast cancer cell line MDA-MB-231 by inducing prodeath autophagy and apoptosis. Nutrients 2020; 12(10): 3175.
[http://dx.doi.org/10.3390/nu12103175] [PMID: 33080824]
[65]
Duran GG, Duran N, Ay E, Kaya DA, Kaya MGA. Eds. Synergistic activities of the essential oils Hypericum perforatum with methotrexate on human breast cancer cell line MCF-7. International Conference on Advanced Materials and Systems (ICAMS). The National Research & Development Institute for Textiles and Leather-INCDTP
[http://dx.doi.org/10.24264/icams-2016.II.9]
[66]
Nseyo U, Shiverick K, Medrano T, Mejia M, Stavropoulos N, Tsimaris I, Eds. The dual effects of polar methanolic extract of Hypericum perforatum L in bladder cancer cells Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI. International Society for Optics and Photonics 2007.
[67]
Stavropoulos NE, Kim A, Nseyo UU, et al. Hypericum perforatum L. extract – Novel photosensitizer against human bladder cancer cells. J Photochem Photobiol B 2006; 84(1): 64-9.
[http://dx.doi.org/10.1016/j.jphotobiol.2006.02.001] [PMID: 16540336]
[68]
Yonar D. Kılıç Süloğlu A, Selmanoğlu G, Sünnetçioğlu MM. An Electron paramagnetic resonance (EPR) spin labeling study in HT-29 Colon adenocarcinoma cells after Hypericin-mediated photodynamic therapy. BMC Mol Cell Biol 2019; 20(1): 16.
[http://dx.doi.org/10.1186/s12860-019-0205-4] [PMID: 31221093]
[69]
Jain SS, Murch SJ, Bird RP, Saxena PK. Optimized St. John’s Wort (Hypericum perforatum L.) germplasm lines exert cytotoxicity in HT-29 colon cancer cells via downregulation of NF-κB. J Complement Integr Med 2010; 7(1): 10.2202/1553-3840.1283.
[http://dx.doi.org/10.2202/1553-3840.1283]
[70]
Mahajna S, Kadan S, Tietel Z, et al. In vitro evaluation of chemically analyzed Hypericum triquetrifolium extract efficacy in apoptosis induction and cell cycle arrest of the HCT-116 colon cancer cell line. Molecules 2019; 24(22): 4139.
[http://dx.doi.org/10.3390/molecules24224139] [PMID: 31731693]
[71]
Xavier CPR, Lima CF, Fernandes-Ferreira M, Pereira-Wilson C. Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway. Food Funct 2012; 3(8): 844-52.
[http://dx.doi.org/10.1039/c2fo10226a] [PMID: 22596086]
[72]
Tian R, Koyabu N, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. Functional induction and de-induction of P-glycoprotein by St. John’s wort and its ingredients in a human colon adenocarcinoma cell line. Drug Metab Dispos 2005; 33(4): 547-54.
[http://dx.doi.org/10.1124/dmd.104.002485] [PMID: 15640377]
[73]
Perloff MD, Von Moltke LL. Störmer E, Shader RI, Greenblatt DJ. Saint John’s wort: An in vitro analysis of P-glycoprotein induction due to extended exposure. Br J Pharmacol 2001; 134(8): 1601-8.
[http://dx.doi.org/10.1038/sj.bjp.0704399] [PMID: 11739235]
[74]
Celik E, Celik MS, Kaplan HM, Singirik ESt. John’s worth extract induces apoptosis and inhibits cancer-related inflamation in basal cell carcinoma cell lines. Biophys J 2019; 116(3): 272a-3a.
[http://dx.doi.org/10.1016/j.bpj.2018.11.1472]
[75]
Sharma KV, Davids LM. Hypericin-PDT-induced rapid necrotic death in human squamous cell carcinoma cultures after multiple treatment. Cell Biol Int 2012; 36(12): 1261-6.
[http://dx.doi.org/10.1042/CBI20120108] [PMID: 23005701]
[76]
Kacerovská D, Pizinger K, Majer F, Šmíd F. Photodynamic therapy of nonmelanoma skin cancer with topical Hypericum perforatum extract--a pilot study. Photochem Photobiol 2008; 84(3): 779-85.
[http://dx.doi.org/10.1111/j.1751-1097.2007.00260.x] [PMID: 18179625]
[77]
Kleemann B, Loos B, Scriba TJ, Lang D, Davids LM. St John’s Wort (Hypericum perforatum L.) photomedicine: Hypericin-photodynamic therapy induces metastatic melanoma cell death. PLoS One 2014; 9(7): e103762.
[http://dx.doi.org/10.1371/journal.pone.0103762] [PMID: 25076130]
[78]
Li Y, Wang Y, Li L, et al. Hyperoside induces apoptosis and inhibits growth in pancreatic cancer via Bcl-2 family and NF-κB signaling pathway both in vitro and in vivo. Tumour Biol 2016; 37(6): 7345-55.
[http://dx.doi.org/10.1007/s13277-015-4552-2] [PMID: 26676634]
[79]
Deng M, Tao L, Qiao Y, et al. New cytotoxic secondary metabolites against human pancreatic cancer cells from the Hypericum perforatum endophytic fungus Aspergillus terreus. Fitoterapia 2020; 146: 104685.
[http://dx.doi.org/10.1016/j.fitote.2020.104685] [PMID: 32673639]
[80]
Čavarga I, Brezáni P, Fedoročko P, et al. Photoinduced antitumour effect of hypericin can be enhanced by fractionated dosing. Phytomedicine 2005; 12(9): 680-3.
[http://dx.doi.org/10.1016/j.phymed.2004.02.011] [PMID: 16194057]
[81]
Bobrov N. Čavarga I, Longauer F, et al. Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy. Phytomedicine 2007; 14(2-3): 172-8.
[http://dx.doi.org/10.1016/j.phymed.2006.09.017] [PMID: 17095201]
[82]
Ferda A, Aztopal N, Erkisa M, Celikler S, Sahin S, Ulukaya E. Nonapoptotic cell death induced by Hypericum species on cancer cells. Eur Respir J 2017; 3(1): 1-10.
[83]
Özmen A, Bauer S, Gridling M, et al. in vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey. Oncol Rep 2009; 22(4): 845-52.
[PMID: 19724864]
[84]
Guclu G, Tas A, Tulimat M, Eruygur N, Silig Y. Anticancer activity of water and methanol extracts of Hypericum scabrum L. on different cancer cell lines. Not Sci Biol 2019; 11(4): 333-6.
[http://dx.doi.org/10.15835/nsb11410597]
[85]
Vijayan P, Kumar SV, Dhanaraj SA, Mukherjee PK, Suresh B. in vitro cytotoxicity and antitumour properties of Hypericum mysorense and Hypericum patulum. Phytother Res 2003; 17(8): 952-6.
[http://dx.doi.org/10.1002/ptr.1271] [PMID: 13680832]
[86]
Hostanska K, Reichling J, Bommer S, Weber M, Saller R. Hyperforin a constituent of St John’s wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. Eur J Pharm Biopharm 2003; 56(1): 121-32.
[http://dx.doi.org/10.1016/S0939-6411(03)00046-8] [PMID: 12837490]
[87]
Guefack M-GF, Damen F, Mbaveng AT. Çelik İ, et al. Cytotoxic constituents of the bark of Hypericum roeperianum towards multidrug-resistant cancer cells. Evid Based Complement Alternat Med 2020; 2020: 4314807.
[http://dx.doi.org/10.1155/2020/4314807]
[88]
Biljali S, Momekov G, Nedialkov P, et al. In vitro investigation of the antiproliferative and proapoptotic effects of hyperatomarin – a bicyclic prenylated acylphloroglucinol from Hypericum annulatum Moris subsp. annulatum against human tumor and endothelial cells. J Pharm Technol Drug Res 2012; 1(1): 6.
[http://dx.doi.org/10.7243/2050-120X-1-6]
[89]
Chen Q, Di L, Zhang Y, Li N. Chemical constituents with cytotoxic and anti-inflammatory activity in Hypericum sampsonii and the antitumor potential under the view of cancer-related inflammation. J Ethnopharmacol 2020; 259: 112948.
[http://dx.doi.org/10.1016/j.jep.2020.112948] [PMID: 32417427]
[90]
Tanaka N, Kashiwada Y, Kim SY, Sekiya M, Ikeshiro Y, Takaishi Y. Xanthones from Hypericum chinense and their cytotoxicity evaluation. Phytochemistry 2009; 70(11-12): 1456-61.
[http://dx.doi.org/10.1016/j.phytochem.2009.08.015] [PMID: 19766276]
[91]
Robinson-Rechavi M, Garcia HE, Laudet V. The nuclear receptor superfamily. J Cell Sci 2003; 116(4): 585-6.
[http://dx.doi.org/10.1242/jcs.00247] [PMID: 12538758]
[92]
Qiu D, Zhou M, Chen J, et al. Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα Phytochemistry 2020; 170: 112216.
[http://dx.doi.org/10.1016/j.phytochem.2019.112216] [PMID: 31841782]
[93]
Andersson ML. Mّøller AM, Wildgaard K. Butyrylcholinesterase deficiency and its clinical importance in anaesthesia: A systematic review. Anaesthesia 2019; 74(4): 518-28.
[http://dx.doi.org/10.1111/anae.14545] [PMID: 30600548]
[94]
Keskin C. Antioxidant, anticancer and anticholinesterase activities of flower, fruit and seed extracts of Hypericum amblysepalum HOCHST. Asian Pac J Cancer Prev 2015; 16(7): 2763-9.
[http://dx.doi.org/10.7314/APJCP.2015.16.7.2763] [PMID: 25854360]
[95]
Madunić J, Matulić M, Friščić M, Pilepić KH. Evaluation of the cytotoxic activity of Hypericum spp. on human glioblastoma A1235 and breast cancer MDA MB-231 cells. J Environ Sci Health Part A Tox Hazard Subst Environ Eng 2016; 51(13): 1157-63.
[http://dx.doi.org/10.1080/10934529.2016.1206385] [PMID: 27458758]
[96]
Manna SK, Golla S, Golla JP, et al. St. John’s wort attenuates colorectal carcinogenesis in mice through suppression of inflammatory signaling. Cancer Prev Res (Phila) 2015; 8(9): 786-95.
[http://dx.doi.org/10.1158/1940-6207.CAPR-14-0113] [PMID: 26069204]
[97]
Branda RF, Powden C, Brooks EM, Yildirim Z, Naud SJ, McCormack JJ. Vitamin E but not St. John’s wort mitigates leukopenia caused by cancer chemotherapy in rats. Transl Res 2006; 148(6): 315-24.
[http://dx.doi.org/10.1016/j.trsl.2006.05.007] [PMID: 17162253]
[98]
Franco P, Rampino M, Ostellino O, et al. Management of acute skin toxicity with Hypericum perforatum and neem oil during platinum-based concurrent chemo-radiation in head and neck cancer patients. Med Oncol 2017; 34(2): 30.
[http://dx.doi.org/10.1007/s12032-017-0886-5] [PMID: 28101834]

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