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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Curcumin Combats against Organophosphate Pesticides Toxicity: A Review of the Current Evidence and Molecular Pathways

Author(s): Amir Masoud Jafari-Nozad, Amirsajad Jafari, Michael Aschner, Tahereh Farkhondeh* and Saeed Samarghandian*

Volume 30, Issue 20, 2023

Published on: 03 October, 2022

Page: [2312 - 2339] Pages: 28

DOI: 10.2174/0929867329666220817125800

Price: $65

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Abstract

Organophosphate compounds are regarded as a class of pesticides that are used in farming. Their extensive use, especially in developing countries, is a serious public health problem. Numerous studies have shown the effects of these toxins on various parts of the human and other vertebrates’ bodies, including the cardiovascular, hepatobiliary, renal, and reproductive systems. Curcumin is a polyphenol compound obtained from the rhizome of the Curcuma longa. Curcumin has been known as a dietary spice, food additive, and traditional medicine since many years ago. In recent decades, the medicinal characteristics, clinical aspects, and biological activity of curcumin have been extensively examined. The most examined positive characteristics of curcumin are its anti- inflammatory and anti-oxidant qualities. This review will deal with the pharmacological properties of curcumin as well as an update of currently available studies in terms of curcumin’s uses and function against organophosphate pesticides-induced toxicity on different human organs.

Keywords: Curcumin, organophosphate, pesticides, toxicity, toxins.

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