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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

同时进行双任务训练对老年轻度认知障碍患者局部脑血流的影响

卷 19, 期 6, 2022

发表于: 17 August, 2022

页: [458 - 468] 页: 11

弟呕挨: 10.2174/1567205019666220627091246

价格: $65

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摘要

背景：以前没有任何研究使用单光子发射计算机断层扫描（SPECT）检测双任务训练对局部脑血流（rCBF）的影响。 目的：本研究旨在通过SPECT检查同时进行运动和认知任务双任务训练对患有遗忘性轻度认知障碍（aMCI）的老年人rCBF的影响。 方法：在这项非随机对照试验中，2016年5月至2018年4月，40名患有aMCI的老年人参加了试验。干预组的门诊患者（n=22）接受了24次（12个月）的dualtask训练，每月两次，每次60分钟。对照组参与者（n=18）继续定期门诊就诊。主要结果是基线时和12个月后的rCBF，使用两样本t检验对各组进行比较。次要结果是12个月后aMCI的逆转率和转化率。 结果：在干预组的22名参与者中，有6人退出；因此，16人被纳入分析。与对照组相比，干预组在多个区域（包括双侧额叶）的rCBF显著增加。然而，轻度认知障碍（MCI）的逆转或转化率没有显著差异。 结论：对患有aMCI的老年人进行双任务训练可增加额回的rCBF，但不能促进MCI向正常认知的恢复。未来的干预研究，如干预后的随访检查，需要考虑长期预后。

关键词: 无症状轻度认知障碍，双任务训练，局部脑血流，单光子发射计算机断层扫描，逆转，转换，非随机对照试验。

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