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Current Drug Metabolism

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ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

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Review Article

Relevance of ABC Transporters in Drug Development

Author(s): Chukwunonso K. Nwabufo*

Volume 23, Issue 6, 2022

Published on: 18 July, 2022

Page: [434 - 446] Pages: 13

DOI: 10.2174/1389200223666220621113524

Price: $65

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Abstract

ATP-binding cassette (ABC) transporters play a critical role in protecting vital organs such as the brain and placenta against xenobiotics, as well as in modulating the pharmacological and toxicological profile of several drug candidates by restricting their penetration through cellular and tissue barriers. This review paper describes the structure and function of ABC transporters as well as the role of P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein in the disposition of drugs. Furthermore, a review of the in vitro and in vivo techniques for evaluating the interaction between drugs and ABC transporters is provided.

Keywords: P-glycoprotein, multidrug resistance-associated protein 2, breast cancer resistance protein, drug development, pharmacokinetics, pharmacodynamics.

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