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Current Drug Discovery Technologies

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ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

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Research Article

Acute Toxicity Study of 5, 11-Dihydroindolo [3, 2-ß]carbazole as per OECD Regulatory Guidelines

Author(s): Navyashree V. Gowda, Shailesh Bhosale and Anoop Kumar*

Volume 20, Issue 1, 2023

Published on: 28 June, 2022

Article ID: e290422204254 Pages: 7

DOI: 10.2174/1570163819666220429095155

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Abstract

Background: 5,11-Dihydroindolo [3, 2-ß]carbazole is one of the phytoconstituent of the Arisaema genus, which might have various important biological activities. Recently, we have predicted the antiviral potential of this phytoconstituent against the Japanese Encephalitis virus (JEV).

Methods: Thus, in the current study, the acute toxicity profile of 5, 11-dihydroindolo [3, 2-ß]carbazole as per OECD regulatory guidelines in female Wistar rats was evaluated.

Results: We did not find any adverse effects, mortality, and altered behaviour in animals after administration of 5, 11-dihydroindolo [3, 2-ß] carbazole at a dose of 300 and 2000 mg/Kg. Furthermore, no significant changes in physiological and haematological parameters were observed. The histopathological study of vital organs also showed no significant changes compared to the control.

Conclusion: Based on the findings of the current investigation, 5, 11-dihydroindolo [3, 2-ß]carbazole is a safe phytoconstituent of the Arisaema genus, which can be explored for various biological activities.

Keywords: 5, 11-Dihydroindolo [3, 2-ß]carbazole, Arisaema, acute toxicity study, female wistar rats, herbal plants, asphyxia.

Graphical Abstract

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