Login Register Cart 0
Generic placeholder image

Current Pediatric Reviews

Editor-in-Chief

ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Intracranial Imaging of Preterm Infants with Suspected Hypoxic Ischemic Encephalopathy: Comparing MRI and Ultrasound

Author(s): Simon S. Ho*, Yujia Zhou and Dhanashree Rajderkar

Volume 19, Issue 2, 2023

Published on: 17 June, 2022

Page: [179 - 186] Pages: 8

DOI: 10.2174/1573396318666220417233146

Price: $65

Open Access Journals Promotions 2
conference banner
Abstract

Aims: We correlate ultrasound, MRI, and clinical findings in neonates with suspected hypoxic ischemic injury.

Background: Recent advances in neuroimaging have led to improved detection of subtle insults associated with neurodevelopmental outcomes, beyond more historically described lesions such as large hemorrhages and hydrocephalus.

Objective: In this study, we compare cranial ultrasound to MRI for the evaluation of suspected HIE in preterm infants.

Methods: 147 premature infant patients with paired ultrasound and MRI exams were retrospectively analyzed to compare imaging finding accuracy and clinical value.

Result: We confirm that ultrasound is highly sensitive and specific for hydrocephalus, ventricular prominence, and gross structural abnormalities. Ultrasound is not a substitute for MRI in cases of small hemorrhages or white matter injury, however, certain US findings were associated with Apgar score and MRI sequelae of HIE.

Conclusion: Choosing between ultrasound and MRI for preterm neonates at risk for intracranial abnormalities based on their strengths can reduce cost and maximize clinical utility. MRI provides a highly sensitive identification of subtle brain injury, yet ultrasound is correlated with the peripartum clinical picture as measured by Apgar score.

Keywords: Hypoxic ischemic injury, neonatal low birth weight, MRI, ultrasound, germinal matrix hemorrhage, hydrocephalus.

« Previous Next »
Graphical Abstract

[1]
Gupta P, Sodhi KS, Saxena AK, Khandelwal N, Singhi P. Neonatal cranial sonography: A concise review for clinicians. J Pediatr Neurosci 2016; 11(1): 7-13.
[http://dx.doi.org/10.4103/1817-1745.181261] [PMID: 27195026]
[2]
Franckx H, Hasaerts D, Huysentruyt K, Cools F. Cranial ultrasound and neurophysiological testing to predict neurological outcome in infants born very preterm. Dev Med Child Neurol 2018; 60(12): 1232-8.
[http://dx.doi.org/10.1111/dmcn.13961] [PMID: 29981239]
[3]
de Vries LS, van Haastert IC, Benders MJ, Groenendaal F. Myth: Cerebral palsy cannot be predicted by neonatal brain imaging. Semin Fetal Neonatal Med 2011; 16(5): 279-87.
[http://dx.doi.org/10.1016/j.siny.2011.04.004] [PMID: 21636334]
[4]
De Vries LS, Van Haastert IL, Rademaker KJ, Koopman C, Groenendaal F. Ultrasound abnormalities preceding cerebral palsy in high-risk preterm infants. J Pediatr 2004; 144(6): 815-20.
[http://dx.doi.org/10.1016/j.jpeds.2004.03.034] [PMID: 15192633]
[5]
Hintz SR, Vohr BR, Bann CM, et al. Preterm neuroimaging and school-age cognitive outcomes. Pediatrics 2018; 142(1): e20174058.
[http://dx.doi.org/10.1542/peds.2017-4058] [PMID: 29945955]
[6]
Plaisier A, Raets MM, Ecury-Goossen GM, et al. Serial cranial ultrasonography or early MRI for detecting preterm brain injury? Arch Dis Child Fetal Neonatal Ed 2015; 100(4): F293-300.
[http://dx.doi.org/10.1136/archdischild-2014-306129] [PMID: 25637006]
[7]
Intrapiromkul J, Northington F, Huisman TAGM, Izbudak I, Meoded A, Tekes A. Accuracy of head ultrasound for the detection of intracranial hemorrhage in preterm neonates: Comparison with brain MRI and susceptibility-weighted imaging. J Neuroradiol 2013; 40(2): 81-8.
[http://dx.doi.org/10.1016/j.neurad.2012.03.006] [PMID: 22633043]
[8]
McCutcheon KC, Wise L, Lewis K, Gilbert B, Bhatia J, Stansfield BK. The utility of cranial ultrasound as a screening tool for neonatal ECMO. J Perinat Med 2020; 48(2): 173-8.
[http://dx.doi.org/10.1515/jpm-2019-0234] [PMID: 31821168]
[9]
de Vries LS, Benders MJ, Groenendaal F. Progress in neonatal neurology with a focus on neuroimaging in the preterm infant. Neuropediatrics 2015; 46(4): 234-41.
[http://dx.doi.org/10.1055/s-0035-1554102] [PMID: 26121069]
[10]
Burkitt K, Kang O, Jyoti R, Mohamed AL, Chaudhari T. Comparison of cranial ultrasound and MRI for detecting BRAIN injury in extremely preterm infants and correlation with neurological outcomes at 1 and 3 years. Eur J Pediatr 2019; 178(7): 1053-61.
[http://dx.doi.org/10.1007/s00431-019-03388-7] [PMID: 31065842]
[11]
Maalouf EF, Duggan PJ, Counsell SJ, et al. Comparison of findings on cranial ultrasound and magnetic resonance imaging in preterm infants. Pediatrics 2001; 107(4): 719-27.
[http://dx.doi.org/10.1542/peds.107.4.719] [PMID: 11335750]
[12]
Nataraj P, Svojsik M, Sura L, et al. Comparing head ultrasounds and susceptibility-weighted imaging for the detection of low-grade hemorrhages in preterm infants. J Perinatol 2021; 41: 736-42.
[http://dx.doi.org/10.1038/s41372-020-00890-x]
[13]
Looney CB, Smith JK, Merck LH, et al. Intracranial hemorrhage in asymptomatic neonates: Prevalence on MR images and relationship to obstetric and neonatal risk factors. Radiology 2007; 242(2): 535-41.
[http://dx.doi.org/10.1148/radiol.2422060133] [PMID: 17179400]
[14]
Ibrahim J, Mir I, Chalak L. Brain imaging in preterm infants <32 weeks gestation: A clinical review and algorithm for the use of cranial ultrasound and qualitative brain MRI. Pediatr Res 2018; 84(6): 799-806.
[http://dx.doi.org/10.1038/s41390-018-0194-6] [PMID: 30315272]
[15]
Malhotra A, Fahey M, Davies-Tuck M, et al. Comparison of preterm and term equivalent age MRI for the evaluation of preterm brain injury. J Perinatol 2017; 37: 864-8.
[http://dx.doi.org/10.1038/jp.2017.39]

Rights & Permissions Print Cite
Article Metrics
35
2
Wayfinder Image
Open Access Journals Promotions
World Prematurity Day
© 2024 Bentham Science Publishers | Privacy Policy