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Review Article

硫氧还蛋白相互作用蛋白(TXNIP):糖尿病干预的潜在靶点

卷 23, 期 7, 2022

发表于: 14 April, 2022

页: [761 - 767] 页: 7

弟呕挨: 10.2174/1389450123666220303092324

价格: $65

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摘要

背景:糖尿病（DM）是一种常见的代谢紊乱，其特征是血糖持续升高。2型糖尿病的特点是胰岛素抵抗和β细胞功能障碍。硫氧还蛋白相互作用蛋白（TXNIP）是控制胰腺β-细胞产生和丢失的因素之一。 目的:近期研究表明，高糖可显著上调TXNIP的表达。TXNIP在β细胞中过表达不仅能诱导细胞凋亡，还能减少胰岛素的分泌。同时，TXNIP缺乏保护β细胞凋亡，导致胰岛素分泌增加。因此，寻找可以调节TXNIP表达和下游信号通路的小分子是至关重要的。因此，抑制TXNIP对糖尿病患者心血管系统及心脏、肾脏等组织均有有益作用。因此，糖尿病治疗必须针对TXNIP的小分子活性，抑制表达，促进内源性细胞数量和胰岛素的产生。 结论:本文综述了TXNIP的作用机制、调控机制及晶体结构。此外，我们强调了TXNIP信号网络如何促进糖尿病，并与抑制糖尿病发展的药物相互作用及其复合物。最后，对TXNIP靶向治疗的现状和前景进行了展望。

关键词: TXNIP、β细胞、DM、FOXO1、ChREBP、胰岛素。

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