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ISSN (Online): 2589-9783

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Review Article

A Review on Structurally Diversified Synthesized Molecules as Monoacylglycerol Lipase Inhibitors and their Therapeutic uses

Author(s): Abhishek Kashyap*, Suresh Kumar and Rohit Dutt

Volume 14, Issue 2, 2022

Published on: 01 April, 2022

Page: [96 - 115] Pages: 20

DOI: 10.2174/2589977514666220301111457

Price: $65

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Abstract

Monoacylglycerol is a metabolic key serine hydrolase engaged in the regulation of the signalling network system of endocannabinoids, which is associated with various physiological processes like pain, inflammation, feeding cognition, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. The monoacylglycerol was also found to act as a regulator and the free fatty acid provider in the proliferation of cancer cells as well as numerous aggressive tumours such as colorectal cancer, neuroblastoma, and nasopharyngeal carcinoma. It also played an important role in increasing the concentration of specific lipids derived from free fatty acids like phosphatidic acid, lysophosphatidic acid, sphingosine-1-phosphate, and prostaglandin E2. These signalling lipids are associated with cell proliferation, survival, tumour cell migration, contribution to tumour development, maturation, and metastases. In this study, we present a review on structurally diverse MAGL inhibitors, their development, and their evaluation for different pharmacological activities.

Keywords: Amino acids, arachidonic acid, 2-arachidonoylglycerol, monoacylglycerol lipase, receptors, enzyme, endocannabinoid system, monoacylglycerol lipase inhibitors.

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