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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Review Article

Maturity-onset Diabetes of the Young (MODY) in Pregnancy: A Review

Author(s): Agata Majewska*, Paweł Stanirowski, Mirosław Wielgoś and Dorota Bomba-Opoń

Volume 19, Issue 1, 2023

Published on: 06 April, 2022

Article ID: e280122200657 Pages: 5

DOI: 10.2174/1573399818666220128124043

Price: $65

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Abstract

Hyperglycaemia in pregnancy is one of the most common complications of pregnancy and is generally diagnosed as gestational diabetes mellitus (GDM). Nevertheless, clinical symptoms of hyperglycaemia in pregnancy in some cases do not match the clinical manifestations of GDM. It is suspected that 1-2 % of women diagnosed with GDM are misdiagnosed maturity-onset diabetes of the young (MODY). MODY often has a subclinical course; thus, it is challenging for clinicians to aptly diagnose monogenic diabetes in pregnancy. Proper diagnosis is crucial for the effective treatment of hyperglycaemia in pregnancy. Many studies revealed that misdiagnosis of MODY increases the rate of complications for both mother and fetus. This literature review reports the current knowledge regarding diagnosis, treatment, and complications of the most common types of MODY in pregnancy.

Keywords: Maturity-onset diabetes of the young, gestational diabetes mellitus, monogenic diabetes, hyperglycaemia in pregnancy, GCK-MODY, HNF1A-MODY.

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