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ISSN (Online): 1875-6646

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Review Article

Kolaviron, A Biflavonoid Compound: Its Pharmacological Activity and Therapeutic Efficacy

Author(s): Damilare Rotimi, Jennifer Chidubem Amanze, Adebola Busola Ojo, Matthew Iyobhebhe, Tobiloba Christiana Elebiyo and Oluwafemi Adeleke Ojo*

Volume 18, Issue 5, 2022

Published on: 15 February, 2022

Article ID: e311221199738 Pages: 9

DOI: 10.2174/1573407218666211231121402

Price: $65

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Abstract

The use of herbal remedies for medicinal purposes is becoming more popular around the world. As a result, plants have become viable treatment options for a variety of diseases. Garcinia kola (bitter kola) is a perennially grown plant in the Guttiferae family that has been evaluated and reported to have numerous health-promoting properties. Kolaviron is a biflavanoid and major phytochemical found in Garcinia kola that includes Garcinia Biflavanoid-1 (GB-1), kolaflavanone, and Garcinia Biflavanoid-2 (GB-2). It is obtained as a fraction extracted from Garcinia kola. Kolaviron's pharmacological properties include anti-inflammatory, anti-spasmodic, ameliorative, anti-asthmatic, anti-cancer, anti-malarial, hepatoprotective, antioxidant, anti-atherogenic, neuroprotective, anti-diabetic, and anti-amnesic properties. Kolaviron is recommended for use in clinical settings because it has been shown to have a high therapeutic efficacy in clinical trials. The purpose of this review is to assess the therapeutic efficacy of kolaviron.

Keywords: Kolaviron, Garcinia kola, pharmacological activities, natural products, therapeutic efficacy, Guttiferae.

Graphical Abstract

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