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Current Psychopharmacology

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ISSN (Print): 2211-5560
ISSN (Online): 2211-5579

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Cerebellum, GABA and Ataxia

Author(s): Robert Lalonde* and Catherine Strazielle

Volume 11, Issue 1, 2022

Published on: 10 December, 2021

Article ID: e221121198193 Pages: 2

DOI: 10.2174/2211556010666211122155811

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Abstract

Various clinical results are obtained regarding the effects of cerebellar GABA transmission on spinocerebellar ataxias. Based on animal studies, it is proposed that balanced GABAergic transmission between GABA and other neurotransmitters such as glutamate may lead to more promising results in treating such conditions.

Keywords: Gamma-aminobutyric acid, spinocerebellar ataxia, Friedreich’s ataxia, glucocorticoids, Golgi cells, cerebellum.

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