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ISSN (Online): 1873-4286

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General Review Article

The Impact of Traditional Chinese Medicine on Mitophagy in Disease Models

Author(s): Li-Ping Yu, Ting-Ting Shi, Yan-Qin Li, Jian-Kang Mu, Ya-Qin Yang, Wei-Xi Li, Jie Yu* and Xing-Xin Yang*

Volume 28, Issue 6, 2022

Published on: 06 October, 2021

Page: [488 - 496] Pages: 9

DOI: 10.2174/1381612827666211006150410

Price: $65

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Abstract

Mitophagy plays an important role in maintaining mitochondrial quality and cell homeostasis through the degradation of damaged, aged, and dysfunctional mitochondria and misfolded proteins. Many human diseases, particularly neurodegenerative diseases, are related to disorders of mitochondrial phagocytosis. Exploring the regulatory mechanisms of mitophagy is of great significance for revealing the molecular mechanisms underlying the related diseases. Herein, we summarize the major mechanisms of mitophagy, the relationship of mitophagy with human diseases, and the role of traditional Chinese medicine (TCM) in mitophagy. These discussions enhance our knowledge of mitophagy and its potential therapeutic targets using TCM.

Keywords: Traditional chinese medicine, mitochondria, mitophagy, parkin, PINK1, BNIP3, Nix, diseases.

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