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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

SILCODE 研究中因忧虑而主观认知下降的个体的教育、APOE ɛ4 和认知

卷 18, 期 6, 2021

发表于: 30 September, 2021

页: [492 - 498] 页: 7

弟呕挨: 10.2174/1567205018666211001105425

价格: $65

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摘要

背景：教育可以对主观认知衰退 (SCD) 个体的认知产生保护作用，这被认为是阿尔茨海默病 (AD) 的早期阶段。然而，教育对具有 SCD-plus 特征的 SCD 个体认知的影响尚不清楚。 目的：本研究的目的是探讨教育对具有 SCD 加特征的 SCD 个体认知的影响。 方法：共有 234 名 SCD 患者来自中国认知衰退纵向研究（SILCODE）。跨 4 个领域（记忆、执行、语言和一般认知功能）评估认知。构建多元线性回归模型来检查教育对无忧虑 (n=91) 和有忧虑 (n=143) 个体认知分数的影响。此外，我们评估了两组 APOE ε4 非携带者和 APOE ε4 携带者之间的影响差异。 结果：多元线性回归分析显示，教育对无忧虑个体的记忆、执行和语言认知以及有忧虑个体的所有认知领域都有积极影响。此外，我们发现教育对 APOE ε4 无忧虑携带者的执行认知和无忧虑 APOE ε4 携带者的语言和一般认知有积极影响。同时，教育对 APOE ε4 携带者的所有认知领域都有积极影响，焦虑的 APOE ε4 携带者的执行、语言和一般认知。 结论：这项研究表明，教育有可能延迟或减少具有 SCD 加特征的 SCD 个体的认知能力下降。

关键词: 阿尔茨海默病，主观认知能力下降，教育，认知储备，载脂蛋白 E，预防。

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