Login Register Cart 0
Generic placeholder image

Current Women`s Health Reviews

Editor-in-Chief

ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Case Report

Vaginitis Due to Pichia fermentans in a Patient Affected by Endometrial Cancer: A Novel Case Report

Author(s): Zarifeh Adampour, Malihe Hasanzadeh, Hossein Zarrinfar*, Maryam Nakhaei and Monika Novak Babi

Volume 18, Issue 4, 2022

Article ID: e031121194726 Pages: 4

DOI: 10.2174/1573404817666210712214458

Price: $65

conference banner
Abstract

Introduction: Endometrial cancer is one of the most common malignancies of the female genital tract, which can be serious or life-threatening. Microbial infections can be one of the underlying causes of this type of cancer.

Case Presentation: The present study describes the isolation of Pichia fermentans (Candida firmentaria var. firmentaria) from the vaginal secretions of a 61-year-old woman affected by endometrial cancer. She reported abdominal pain and vaginal discharge for 3 months, and had a history of diabetes, hypertension, Deep Vein Thrombosis (DVT), and Acute Myeloid Leukemia (AML). The isolated yeast was identified based on nuclear ribosomal internal transcribed spacer (ITS1-ITS2 rDNA) sequence analysis. The in vitro antifungal susceptibility testing showed a higher effect for ketoconazole against P. fermentans than fluconazole, itraconazole and voriconazole.

Conclusion: Correct differentiation between P. fermentans and other yeast should be considered. In vitro antifungal susceptibility testing is recommended for rare yeast, and will help the physicians in providing the best treatment.

Keywords: Vaginitis, Pichia fermentans, uterine cancer, Candida, woman, PCR.

Graphical Abstract

[1]
Sweet MG, Schmidt-Dalton TA, Weiss PM, Madsen KP. Evaluation and management of abnormal uterine bleeding in premenopausal women. Am Fam Physician 2012; 85(1): 35-43.
[PMID: 22230306]
[2]
Krause M, Wheeler TL, Snyder TE, Richter HE, TES II. Local effects of vaginally administered estrogen therapy: A review. J Pelvic Med Surg 2009; 15(3): 105-14.
[http://dx.doi.org/10.1097/SPV.0b013e3181ab4804] [PMID: 22229022]
[3]
Duska LR. Recognising endometrial cancer in pre-menopausal women. BJOG 2017; 124(3): 412.
[http://dx.doi.org/10.1111/1471-0528.14487] [PMID: 28120543]
[4]
Hasanzadeh M, Zarrinfar H, Najjari M. Unusual vaginal bleeding due to a leech bite in a girl from a tropical area: A case report. Rev Soc Bras Med Trop 2019; 52: e20180425.
[http://dx.doi.org/10.1590/0037-8682-0425-2018] [PMID: 30994809]
[5]
Chang AH, Parsonnet J. Role of bacteria in oncogenesis. Clin Microbiol Rev 2010; 23(4): 837-57.
[http://dx.doi.org/10.1128/CMR.00012-10] [PMID: 20930075]
[6]
Bitew A, Abebaw Y. Vulvovaginal candidiasis: Species distribution of Candida and their antifungal susceptibility pattern. BMC Womens Health 2018; 18(1): 94.
[http://dx.doi.org/10.1186/s12905-018-0607-z] [PMID: 29902998]
[7]
Minooeianhaghighi MH, Sehatpour M, Zarrinfar H, Sen T. Recurrent vulvovaginal candidiasis: The causative agents, clinical signs and susceptibility to fluconazole in Gonabad city, Northeast Iran. Curr Womens Health Rev 2020; 16(1): 46-51.
[http://dx.doi.org/10.2174/1573404815666191104142813]
[8]
Tashiro A, Nei T, Sugimoto R, et al. Kodamaea ohmeri fungemia in severe burn: Case study and literature review. Med Mycol Case Rep 2018; 22: 21-3.
[http://dx.doi.org/10.1016/j.mmcr.2018.07.005] [PMID: 30094134]
[9]
Zarrinfar H, Kaboli S, Dolatabadi S, Mohammadi R. Rapid detection of Candida species in bronchoalveolar lavage fluid from patients with pulmonary symptoms. Braz J Microbio 2016; 47(1): 172-6.
[10]
Schmalreck AF, Lackner M, Becker K, et al. Phylogenetic relationships matter: Antifungal susceptibility among clinically relevant yeasts. Antimicrob Agents Chemother 2014; 58(3): 1575-85.
[http://dx.doi.org/10.1128/AAC.01799-13] [PMID: 24366735]
[11]
Sobel JD, Faro S, Force RW, et al. Vulvovaginal candidiasis: Epidemiologic, diagnostic, and therapeutic considerations. Am J Obstet Gynecol 1998; 178(2): 203-11.
[http://dx.doi.org/10.1016/S0002-9378(98)80001-X] [PMID: 9500475]
[12]
Khorsand I, Ghanbari Nehzag MA, Zarrinfar H, Fata A, Naseri A, Badiee P. Frequency of variety of Candida species in women with Candida vaginitis referred to clinical centers of Mashhad, Iran. Majallah-i Zanan, Mamai va Nazai-i Iran 2015; 18(168): 15-22.
[13]
Kord Z, Fata A, Zarrinfar H. Molecular identification of Candida species isolated from patients with vulvovaginitis for the first time in Mashhad. Majallah-i Zanan, Mamai va Nazai-i Iran 2017; 20(4): 50-7.
[14]
Limon JJ, Skalski JH, Underhill DM. Commensal fungi in health and disease. Cell Host Microbe 2017; 22(2): 156-65.
[http://dx.doi.org/10.1016/j.chom.2017.07.002] [PMID: 28799901]
[15]
Hedayati MT, Taheri Z, Galinimoghadam T, Aghili SR, Yazdani Cherati J, Mosayebi E. Isolation of different species of Candida in patients with vulvovaginal candidiasis from sari, iran. Jundishapur J Microbiol 2015; 8(4): e15992.
[http://dx.doi.org/10.5812/jjm.8(4)2015.15992] [PMID: 26034533]
[16]
Nazeri M, Mesdaghinia E, Moravej SAR, Atabakhshiyan R, Soleymani F. Prevalence of vulvovaginal candidiasis and frequency of Candida species in women. Majallah-i Danishgah-i Ulum-i Pizishki-i Mazandaran 2012; 21(86): 254-62.

Rights & Permissions Print Cite
Article Metrics
31
1
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy