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General Review Article

靶向光动力治疗黑色素瘤和头颈部肿瘤的微环境

卷 29, 期 18, 2022

发表于: 09 July, 2021

页: [3261 - 3299] 页: 39

弟呕挨: 10.2174/0929867328666210709113032

价格: $65

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摘要

背景：与其他皮肤癌相比，光动力疗法(PDT)由于黑色素的强吸收和在细胞保护方面的作用，对黑色素瘤的作用仍然差得多。肿瘤微环境(TME)在肿瘤进展中起着重要作用，而缺氧的TME是黑色素瘤进展到转移及其对PDT的耐药性的主要原因之一。缺氧也是头颈部实体肿瘤的一个特征，表明预后为阴性。 目的：本研究的目的是个性化和系统地描述针对TME，特别是缺氧的PDT治疗黑色素瘤和头颈部癌（异氢氰酸）的主要策略，并评估其目前的应用成功。 方法：使用PubMed在医学线和其他数据库中搜索关于抗黑色素瘤和异氢氰酸结合TME靶向和缺氧的最新出版物。 结果：在PDT治疗黑色素瘤和异氢氰酸中，控制缺氧水平非常重要，在不同的方法中，经常应用氧气自供系统。血管靶向性是很有前途的，但为了改善它，必须建立最佳的药物-光间隔时间和增加光敏剂在肿瘤血管系统中的积累的配方。另一方面，血管生成抑制剂的使用，如那些干扰VEGF信号传导的抑制剂，还不如预期的那么成功，需要进一步的研究。 结论：PDT与免疫治疗的联合应用不断发展，似乎是最有希望实现完整和持久的抗肿瘤效果。

关键词: 光动力疗法，光敏剂，肿瘤微环境，缺氧，黑色素瘤，头颈部癌症。

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