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Review Article

针对基孔肯雅病毒侵入：发现新的抑制剂替代品药物

卷 29, 期 4, 2022

发表于: 23 June, 2021

页: [612 - 634] 页: 23

弟呕挨: 10.2174/0929867328666210623165005

价格: $65

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摘要

基孔肯雅病毒 (CHIKV) 是导致基孔肯雅热 (CHIKF) 的甲病毒 (Togaviridae)，其主要特征是严重的多关节痛，通过受感染的埃及伊蚊和伊蚊叮咬传播。白纹蚊。如今，没有获得许可的疫苗或批准的药物来专门治疗这种病毒性疾病。结构病毒蛋白参与其复制周期的关键步骤，例如病毒进入、膜融合、核衣壳组装和病毒出芽。在这种情况下，包膜 E3-E2-E1 糖蛋白复合物可以作为设计新候选药物的目标。在这篇综述中，讨论了 CHIKV 进入机制的各个方面，以提供有助于药物发现过程的见解。此外，还探索了几种天然的、基于天然的和合成的化合物，以及重新利用的药物和虚拟筛选，作为开发 CHIKV 进入抑制剂的替代方案。最后，我们对未通过计算机方法探索的抑制剂进行了补充分析。基于此，发现 Phe118、Val179 和 Lys181 是最常见的残基，分别存在于 89.6、82.7 和 93.1% 的复合物中。最后，讨论了与这些抑制剂和成熟包膜 E3-E2-E1 糖蛋白复合物相互作用相关的一些化学问题，以全世界的科学家提供数据为基础，以支持他们寻找针对这种新兴虫媒病毒的新抑制剂。

关键词: 靶点抑制剂、基孔肯雅病毒、药物化学、药物设计、再利用、天然产物、合成、虚拟筛选、分子对接、频率残基。

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