Abstract
Background: The global alliance for genomics and healthcare facilities provides innovative solutions to expedite research and clinical practices for complex and incurable health conditions. Precision oncology is an emerging field explicitly tailored to facilitate cancer diagnosis, prevention, and treatment based on patients’ genetic profiles. Advancements in “omics” techniques, next-generation sequencing, artificial intelligence, and clinical trial designs provide a platform for assessing the efficacy and safety of combination therapies and diagnostic procedures.
Methods: Data were collected from PubMed and Google Scholar using keywords “Precision medicine,” “precision medicine and cancer,” “anticancer agents in precision medicine,” and reviewed comprehensively.
Results: Personalized therapeutics, including immunotherapy and cancer vaccines, serve as a groundbreaking solution for cancer treatment. Herein, we take a measurable view of precision therapies and novel diagnostic approaches targeting cancer treatment. The contemporary applications of precision medicine have also been described, along with various hurdles identified in the successful establishment of precision therapeutics.
Conclusion: This review highlights the key breakthroughs related to immunotherapies, targeted anticancer agents, and target interventions related to cancer signaling mechanisms. The success story of this field in context to drug resistance, safety, patient survival, and improving quality of life is yet to be elucidated. We conclude that, in the near future, the field of individualized treatments may truly revolutionize the nature of cancer patient care.
Keywords: Precision medicine, anticancer agents, cancer, personalized therapies, randomization, oncology.
[http://dx.doi.org/10.1038/nrclinonc.2017.166]
[http://dx.doi.org/10.3389/fphar.2018.01300] [PMID: 30483135]
[http://dx.doi.org/10.1186/s12967-019-1864-9] [PMID: 30953518]
[http://dx.doi.org/10.1038/nrd.2017.218] [PMID: 29170471]
[http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0003] [PMID: 27144059]
[http://dx.doi.org/10.1177/0033354916689662] [PMID: 28135429]
[http://dx.doi.org/10.1016/S1470-2045(15)00620-8] [PMID: 26868357]
[http://dx.doi.org/10.1142/S2339547818300020]
[http://dx.doi.org/10.3390/jpm9030043] [PMID: 31492009]
[http://dx.doi.org/10.1056/NEJMoa1708539] [PMID: 28891408]
[http://dx.doi.org/10.1001/jamaoncol.2016.1025] [PMID: 27228256]
[http://dx.doi.org/10.1016/S1470-2045(18)30096-2] [PMID: 29726389]
[http://dx.doi.org/10.1056/NEJMoa041588] [PMID: 15591335]
[http://dx.doi.org/10.1200/JCO.2009.23.7610] [PMID: 20065188]
[http://dx.doi.org/10.1200/JCO.2009.27.4324] [PMID: 20823417]
[http://dx.doi.org/10.1200/PO.18.00034] [PMID: 32914000]
[http://dx.doi.org/10.1016/j.radonc.2014.11.011] [PMID: 25480095]
[http://dx.doi.org/10.1038/ncb3312] [PMID: 26911908]
[http://dx.doi.org/10.1038/nprot.2016.174] [PMID: 28125105]
[http://dx.doi.org/10.1073/pnas.0907676107] [PMID: 20404174]
[http://dx.doi.org/10.1038/s41578-018-0034-7]
[http://dx.doi.org/10.1371/journal.pone.0216564] [PMID: 31075118]
[http://dx.doi.org/10.1002/bit.25950] [PMID: 26888480]
[http://dx.doi.org/10.1038/srep31589] [PMID: 27549930]
[http://dx.doi.org/10.1038/nrclinonc.2017.8] [PMID: 28169302]
[http://dx.doi.org/10.1038/nrclinonc.2010.43] [PMID: 20368727]
[http://dx.doi.org/10.4155/cli.15.15]
[http://dx.doi.org/10.4097/kja.19049] [PMID: 30929415]
[http://dx.doi.org/10.1016/j.clon.2017.10.005] [PMID: 29108786]
[http://dx.doi.org/10.1002/1878-0261.12465] [PMID: 30698321]
[http://dx.doi.org/10.1158/2159-8290.CD-13-0350] [PMID: 24056683]
[http://dx.doi.org/10.1186/s13063-019-3664-1]
[http://dx.doi.org/10.1093/annonc/mdw413] [PMID: 28177494]
[PMID: 26408303]
[http://dx.doi.org/10.1158/1078-0432.CCR-15-0354] [PMID: 26672084]
[http://dx.doi.org/10.1200/JCO.2018.77.9777] [PMID: 29989854]
[http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.2502]
[http://dx.doi.org/10.1093/annonc/mdz253]
[http://dx.doi.org/10.1056/NEJMoa1714448] [PMID: 29466156]
[http://dx.doi.org/10.1038/nrd.2018.6] [PMID: 29520093]
[http://dx.doi.org/10.1158/2159-8290.CD-18-0338] [PMID: 29657135]
[http://dx.doi.org/10.1016/j.jmoldx.2015.07.006] [PMID: 26602013]
[http://dx.doi.org/10.1016/j.currproblcancer.2017.05.003] [PMID: 28625332]
[http://dx.doi.org/10.1200/JCO.2012.45.2268] [PMID: 23589551]
[http://dx.doi.org/10.3389/fimmu.2019.02854] [PMID: 31921125]
[http://dx.doi.org/10.21037/tcr.2019.12.50]
[http://dx.doi.org/10.1016/j.bcp.2013.12.007] [PMID: 24355563]
[http://dx.doi.org/10.1016/j.jconrel.2018.09.025] [PMID: 30290244]
[http://dx.doi.org/10.1021/acs.jmedchem.7b00137] [PMID: 28591512]
[http://dx.doi.org/10.1073/pnas.1120068109] [PMID: 22753465]
[http://dx.doi.org/10.1111/1759-7714.12143] [PMID: 26767041]
[http://dx.doi.org/10.1016/0092-8674(91)90111-B] [PMID: 1831692]
[PMID: 31894255]
[http://dx.doi.org/10.1002/ijc.27863] [PMID: 23001755]
[http://dx.doi.org/10.1371/journal.pone.0025264] [PMID: 21980408]
[http://dx.doi.org/10.1016/S1470-2045(19)30091-9] [PMID: 31101489]
[http://dx.doi.org/10.1016/S0140-6736(18)32984-2] [PMID: 30522922]
[http://dx.doi.org/10.1056/NEJMoa1509277] [PMID: 27292104]
[http://dx.doi.org/10.18632/oncotarget.2840] [PMID: 25483102]
[http://dx.doi.org/10.1186/1477-3155-9-40] [PMID: 21929751]
[http://dx.doi.org/10.1016/j.molonc.2013.11.002] [PMID: 24309677]
[http://dx.doi.org/10.1126/science.272.5268.1668]
[http://dx.doi.org/10.1126/science.280.5369.1603]
[http://dx.doi.org/10.1111/j.1349-7006.2011.02010.x] [PMID: 21679342]
[http://dx.doi.org/10.1016/j.chembiol.2017.02.010] [PMID: 28286127]
[http://dx.doi.org/10.1038/nrg1879] [PMID: 16847462]
[http://dx.doi.org/10.1002/0471142905.hg1011s57] [PMID: 18428421]
[http://dx.doi.org/10.1186/s12943-019-0954-x] [PMID: 30782187]
[http://dx.doi.org/10.1158/1535-7163.MCT-11-0474] [PMID: 22188813]
[http://dx.doi.org/10.1182/blood-2014-07-587279] [PMID: 25258342]
[http://dx.doi.org/10.1158/1535-7163.MCT-13-0865] [PMID: 24608574]
[http://dx.doi.org/10.1158/2159-8290.CD-16-0795] [PMID: 28363909]
[http://dx.doi.org/10.1056/NEJMoa1314583] [PMID: 24450858]
[PMID: 14617782]
[http://dx.doi.org/10.1038/nrd1902] [PMID: 16341064]
[http://dx.doi.org/10.1042/BJ20050908] [PMID: 16293107]
[http://dx.doi.org/10.21037/hbsn.2018.08.06] [PMID: 30652097]
[http://dx.doi.org/10.1158/2159-8290.CD-17-1355] [PMID: 29431672]
[http://dx.doi.org/10.1158/2159-8290.CD-12-0097] [PMID: 22798288]
[http://dx.doi.org/10.1038/nrc2602] [PMID: 19238148]
[http://dx.doi.org/10.2174/1381612003400948] [PMID: 10788588]
[http://dx.doi.org/10.1016/S1470-2045(14)71159-3] [PMID: 25524798]
[http://dx.doi.org/10.1021/ar0201198] [PMID: 12809528]
[http://dx.doi.org/10.2174/1389557511009011058] [PMID: 21047304]
[http://dx.doi.org/10.1158/1078-0432.CCR-11-1536] [PMID: 22016509]
[http://dx.doi.org/10.1038/nrc.2016.138] [PMID: 28127048]
[http://dx.doi.org/10.1158/1535-7163.MCT-13-0206] [PMID: 23873848]
[http://dx.doi.org/10.1158/1078-0432.CCR-08-2445] [PMID: 19383823]
[http://dx.doi.org/10.1002/mc.23035] [PMID: 31062416]
[PMID: 12873987]
[http://dx.doi.org/10.1158/1078-0432.CCR-13-1117] [PMID: 24097866]
[http://dx.doi.org/10.1016/j.ijrobp.2019.08.009] [PMID: 31419512]
[http://dx.doi.org/10.1093/nar/gkv1136] [PMID: 26519467]
[http://dx.doi.org/10.1158/0008-5472.CAN-08-0763] [PMID: 18794134]
[http://dx.doi.org/10.1158/1535-7163.MCT-08-0492] [PMID: 18790776]
[http://dx.doi.org/10.1021/jm400487c] [PMID: 23808545]
[PMID: 32597418]
[http://dx.doi.org/10.1038/onc.2015.280]
[http://dx.doi.org/10.1073/pnas.1314239110] [PMID: 24277854]
[http://dx.doi.org/10.1158/1078-0432.CCR-17-2157] [PMID: 28954784]
[http://dx.doi.org/10.1111/cas.12471] [PMID: 24975284]
[http://dx.doi.org/10.18632/oncotarget.25340] [PMID: 29872501]
[http://dx.doi.org/10.1158/1078-0432.CCR-16-1179] [PMID: 27663586]
[http://dx.doi.org/10.1182/blood-2008-11-191577] [PMID: 19417213]
[http://dx.doi.org/10.1021/bi0512602] [PMID: 16300398]
[http://dx.doi.org/10.1158/1078-0432.CCR-15-3135] [PMID: 27342398]
[http://dx.doi.org/10.1056/NEJMe1400055] [PMID: 24620870]
[http://dx.doi.org/10.1158/1535-7163.MCT-14-0833] [PMID: 25637314]
[http://dx.doi.org/10.1186/1756-9966-29-34] [PMID: 20412566]
[http://dx.doi.org/10.1158/1535-7163.MCT-11-0824-T] [PMID: 22294718]
[http://dx.doi.org/10.1158/2159-8290.CD-16-0512] [PMID: 27872130]
[http://dx.doi.org/10.1038/s41419-018-0943-9]
[http://dx.doi.org/10.1371/journal.pone.0036856] [PMID: 22590625]
[PMID: 27648364]
[http://dx.doi.org/10.1158/0008-5472.CAN-06-4490] [PMID: 17363557]
[http://dx.doi.org/10.18632/oncotarget.23091] [PMID: 29416647]
[http://dx.doi.org/10.1158/0008-5472.CAN-09-1751] [PMID: 20028854]
[http://dx.doi.org/10.1016/j.pharmthera.2013.11.011] [PMID: 24325952]
[http://dx.doi.org/10.1007/s40265-013-0096-1] [PMID: 23846731]
[http://dx.doi.org/10.1007/s00280-015-2862-0] [PMID: 26365290]
[http://dx.doi.org/10.1186/s12885-016-2199-z] [PMID: 26925841]
[http://dx.doi.org/10.1517/13543784.2015.982275] [PMID: 25385055]
[http://dx.doi.org/10.1158/1535-7163.MCT-17-0456] [PMID: 28939558]
[http://dx.doi.org/10.1186/bcr3621] [PMID: 24887180]
[http://dx.doi.org/10.1093/annonc/mdl475] [PMID: 17229773]
[http://dx.doi.org/10.1158/1078-0432.CCR-14-1373] [PMID: 25324140]
[http://dx.doi.org/10.1038/s41418-020-0505-4] [PMID: 32042099]
[http://dx.doi.org/10.1158/1078-0432.CCR-14-2797] [PMID: 25724527]
[http://dx.doi.org/10.1038/s41419-018-0804-6] [PMID: 29970890]
[http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.2515]
[http://dx.doi.org/10.1126/scitranslmed.aau6246] [PMID: 31142678]
[http://dx.doi.org/10.1021/ml2002423] [PMID: 24900436]
[http://dx.doi.org/10.1021/ml1000307] [PMID: 24900187]
[http://dx.doi.org/10.1016/j.bmcl.2009.08.049] [PMID: 19716296]
[http://dx.doi.org/10.1038/nchembio.142] [PMID: 19151731]
[http://dx.doi.org/10.1016/S0092-8674(00)81386-0] [PMID: 8929535]
[http://dx.doi.org/10.1073/pnas.0609699104] [PMID: 17494766]
[http://dx.doi.org/10.1073/pnas.0907134106] [PMID: 19666565]
[http://dx.doi.org/10.1158/1078-0432.CCR-040020] [PMID: 15217973]
[PMID: 26207228]
[http://dx.doi.org/10.1038/sj.cdd.4402257] [PMID: 17975552]
[http://dx.doi.org/10.1158/1535-7163.MCT-10-0324] [PMID: 20663931]
[http://dx.doi.org/10.4161/cbt.12.7.16475] [PMID: 21768779]
[PMID: 15542782]
[http://dx.doi.org/10.1056/NEJMoa1609709] [PMID: 27717303]
[http://dx.doi.org/10.2147/OTT.S149245] [PMID: 30214230]
[http://dx.doi.org/10.1158/1535-7163.MCT-14-0710] [PMID: 25567130]
[http://dx.doi.org/10.1186/s13073-016-0324-x] [PMID: 27323951]
[http://dx.doi.org/10.1158/1535-7163.MCT-10-0928] [PMID: 21321066]
[http://dx.doi.org/10.3389/fphar.2019.00864] [PMID: 31427973]
[http://dx.doi.org/10.4161/cbt.12.9.17673] [PMID: 21892012]
[http://dx.doi.org/10.1016/j.ccr.2005.02.009] [PMID: 15766665]
[http://dx.doi.org/10.1016/j.apsb.2019.02.001] [PMID: 31649851]
[http://dx.doi.org/10.1016/j.ijrobp.2011.01.060] [PMID: 21514073]
[http://dx.doi.org/10.1602/neurorx.1.2.182] [PMID: 15717018]
[http://dx.doi.org/10.1177/1758834009360519] [PMID: 21789130]
[http://dx.doi.org/10.1158/1078-0432.CCR-13-3271] [PMID: 24714771]
[http://dx.doi.org/10.1200/JCO.2009.26.7609] [PMID: 20516446]
[http://dx.doi.org/10.1016/j.jtho.2017.07.031] [PMID: 28818609]
[http://dx.doi.org/10.1016/j.jmoldx.2014.12.006] [PMID: 25801821]
[http://dx.doi.org/10.1093/annonc/mdy495] [PMID: 30395155]
[http://dx.doi.org/10.1056/NEJMoa1311194] [PMID: 24645800]
[http://dx.doi.org/10.1038/ajg.2017.285] [PMID: 29016558]
[http://dx.doi.org/10.1056/NEJMoa1903387] [PMID: 31157963]
[http://dx.doi.org/10.1586/14737159.2015.1078238] [PMID: 26292709]
[http://dx.doi.org/10.1016/j.juro.2013.02.018] [PMID: 23416644]
[http://dx.doi.org/10.1186/s12967-019-2079-9] [PMID: 31570105]
[http://dx.doi.org/10.1038/nm.3519] [PMID: 24705333]
[http://dx.doi.org/10.1038/cr.2014.44] [PMID: 24710597]
[http://dx.doi.org/10.1186/s12943-018-0876-z] [PMID: 30139385]
[http://dx.doi.org/10.3390/ncrna3010009] [PMID: 29657281]
[http://dx.doi.org/10.1038/srep08057] [PMID: 25624062]
[http://dx.doi.org/10.1016/j.cca.2015.02.018] [PMID: 25689795]
[http://dx.doi.org/10.1007/s12282-017-0793-9] [PMID: 28721656]
[http://dx.doi.org/10.1016/j.canlet.2018.01.011] [PMID: 29330104]
[http://dx.doi.org/10.1371/journal.pone.0092921] [PMID: 24705249]
[http://dx.doi.org/10.1016/j.ygyno.2008.04.033] [PMID: 18589210]
[http://dx.doi.org/10.1002/emmm.201100209] [PMID: 22351564]
[http://dx.doi.org/10.1038/nrclinonc.2014.5] [PMID: 24492836]
[http://dx.doi.org/10.1038/srep25997] [PMID: 27180809]
[http://dx.doi.org/10.3390/cells9020276] [PMID: 31979244]
[http://dx.doi.org/10.3892/ol.2016.5462] [PMID: 28356944]
[http://dx.doi.org/10.1177/1010428317699125] [PMID: 28443463]
[http://dx.doi.org/10.1016/j.cca.2017.01.025] [PMID: 28130019]
[http://dx.doi.org/10.1200/JCO.2020.38.15_suppl.e15265]
[http://dx.doi.org/10.18632/oncotarget.10015] [PMID: 27329591]
[http://dx.doi.org/10.1245/s10434-011-1581-y] [PMID: 21327457]
[http://dx.doi.org/10.1177/147323001103900608] [PMID: 22289527]
[http://dx.doi.org/10.1158/0008-5472.CAN-11-1021] [PMID: 21862635]
[http://dx.doi.org/10.1038/onc.2012.193] [PMID: 22614017]
[http://dx.doi.org/10.1007/s10549-013-2776-7] [PMID: 24258260]
[http://dx.doi.org/10.1016/j.mam.2015.05.003] [PMID: 26022941]
[http://dx.doi.org/10.1016/j.gene.2017.08.027] [PMID: 28864116]
[http://dx.doi.org/10.18632/oncotarget.27284] [PMID: 31762940]
[http://dx.doi.org/10.1007/s10549-019-05446-y] [PMID: 31542876]
[http://dx.doi.org/10.3389/fonc.2020.00845] [PMID: 32528899]
[http://dx.doi.org/10.1371/journal.pone.0043470] [PMID: 22916267]
[http://dx.doi.org/10.1186/1476-4598-9-198] [PMID: 20663213]
[http://dx.doi.org/10.3390/cells9030541] [PMID: 32111002]
[http://dx.doi.org/10.1371/journal.pone.0010630] [PMID: 20498843]
[http://dx.doi.org/10.1093/neuonc/nos074] [PMID: 22492962]
[http://dx.doi.org/10.5732/cjc.010.10522] [PMID: 21627863]
[http://dx.doi.org/10.1155/2015/435656] [PMID: 26063956]
[PMID: 29516946]
[http://dx.doi.org/10.1007/s13277-013-0753-8] [PMID: 23625654]
[PMID: 11380282]
[http://dx.doi.org/10.2174/156652321402140318165450] [PMID: 24665839]
[http://dx.doi.org/10.1101/cshperspect.a023754] [PMID: 27908936]
[http://dx.doi.org/10.1038/s41392-019-0089-y] [PMID: 32296011]
[http://dx.doi.org/10.1016/j.tibtech.2013.04.004] [PMID: 23664777]
[http://dx.doi.org/10.1038/nrg3686] [PMID: 24690881]
[http://dx.doi.org/10.2174/1566523215666150818110241] [PMID: 26282844]
[http://dx.doi.org/10.1182/blood.V126.23.2046.2046]
[http://dx.doi.org/10.1038/cgt.2012.93] [PMID: 23370333]
[http://dx.doi.org/10.1007/s11095-018-2436-z] [PMID: 29855723]
[http://dx.doi.org/10.1634/theoncologist.2019-0646] [PMID: 32339368]
[http://dx.doi.org/10.1158/1078-0432.CCR-18-2035] [PMID: 30309857]
[http://dx.doi.org/10.1038/nrclinonc.2017.156] [PMID: 28975930]
[http://dx.doi.org/10.1056/NEJMoa1709866] [PMID: 29385370]
[http://dx.doi.org/10.3389/fimmu.2019.02711] [PMID: 31824500]
[http://dx.doi.org/10.1186/s13045-019-0819-1] [PMID: 31703740]
[http://dx.doi.org/10.18632/oncotarget.12739] [PMID: 27764780]
[http://dx.doi.org/10.1038/nrclinonc.2016.25] [PMID: 26977780]
[http://dx.doi.org/10.1016/j.immuni.2013.07.012] [PMID: 23890059]
[http://dx.doi.org/10.1186/s40880-019-0379-3] [PMID: 31200766]
[http://dx.doi.org/10.1007/978-3-030-16391-4_7]
[http://dx.doi.org/10.1634/theoncologist.2015-0498] [PMID: 27026676]
[http://dx.doi.org/10.1634/theoncologist.2017-0078] [PMID: 28835513]
[http://dx.doi.org/10.1517/14712598.2016.1145652] [PMID: 26800463]
[http://dx.doi.org/10.1158/1078-0432.CCR-16-0663] [PMID: 28235882]
[http://dx.doi.org/10.1634/theoncologist.2018-0221] [PMID: 30120163]
[http://dx.doi.org/10.1007/s40265-014-0244-2] [PMID: 24916147]
[http://dx.doi.org/10.1634/theoncologist.2016-0496] [PMID: 28533473]
[http://dx.doi.org/10.1634/theoncologist.2015-0507] [PMID: 26984449]
[http://dx.doi.org/10.1634/theoncologist.2017-0087] [PMID: 28424325]
[http://dx.doi.org/10.1158/1078-0432.CCR-17-0540] [PMID: 28611199]
[http://dx.doi.org/10.1007/s40265-017-0749-6] [PMID: 28456944]
[http://dx.doi.org/10.1155/2019/4508794] [PMID: 30941175]
[http://dx.doi.org/10.1186/s40425-019-0672-3] [PMID: 31340861]
[http://dx.doi.org/10.1186/s12943-019-1091-2] [PMID: 31690319]
[http://dx.doi.org/10.1038/s41423-020-00549-9] [PMID: 32963356]
[http://dx.doi.org/10.1080/2162402X.2015.1107698] [PMID: 27141392]
[http://dx.doi.org/10.1056/NEJMoa1001294] [PMID: 20818862]
[http://dx.doi.org/10.1186/s40425-016-0158-5] [PMID: 27660707]
[http://dx.doi.org/10.1002/cncr.23669] [PMID: 18646045]
[http://dx.doi.org/10.4161/onci.24523] [PMID: 23762812]
[http://dx.doi.org/10.1155/2020/1924379] [PMID: 32411789]
[http://dx.doi.org/10.1126/science.181845]
[http://dx.doi.org/10.1158/1078-0432.CCR-18-2722] [PMID: 30518633]
[http://dx.doi.org/10.18632/oncotarget.25163] [PMID: 29805739]
[http://dx.doi.org/10.1634/theoncologist.2019-0233] [PMID: 32043764]
[http://dx.doi.org/10.1177/1060028020948165] [PMID: 32762363]
[http://dx.doi.org/10.1056/NEJMoa1707447] [PMID: 29226797]
[http://dx.doi.org/10.1634/theoncologist.2019-0395] [PMID: 31585984]
[http://dx.doi.org/10.3390/biomedicines5020034] [PMID: 28635679]
[http://dx.doi.org/10.1016/S0092-8674(00)81683-9] [PMID: 10647931]
[http://dx.doi.org/10.1038/s41598-017-07524-x] [PMID: 28769049]
[http://dx.doi.org/10.3390/jcm5060056] [PMID: 27275837]
[http://dx.doi.org/10.1038/ncprheum0647] [PMID: 17968334]
[http://dx.doi.org/10.1097/PPO.0000000000000138] [PMID: 26222078]
[http://dx.doi.org/10.1016/0959-8049(95)00169-J] [PMID: 7577000]
[http://dx.doi.org/10.1038/nm0195-27] [PMID: 7584949]
[http://dx.doi.org/10.1016/j.gde.2004.12.005] [PMID: 15661540]
[http://dx.doi.org/10.1007/s10555-007-9094-7] [PMID: 17717633]
[http://dx.doi.org/10.1038/nrc905] [PMID: 12360276]
[http://dx.doi.org/10.1038/nrd2115] [PMID: 17396134]
[http://dx.doi.org/10.1111/bph.12344] [PMID: 23962094]
[http://dx.doi.org/10.1016/j.bbrc.2007.02.156] [PMID: 17367763]
[http://dx.doi.org/10.3109/10428194.2016.1146949] [PMID: 26902680]
[http://dx.doi.org/10.1093/annonc/mdv102] [PMID: 25712458]
[http://dx.doi.org/10.1200/JCO.2020.38.15_suppl.4585]
[http://dx.doi.org/10.1200/JCO.2004.11.022] [PMID: 15169807]
[http://dx.doi.org/10.1634/theoncologist.12-6-713] [PMID: 17602060]
[http://dx.doi.org/10.1371/journal.pone.0081858] [PMID: 24324725]
[http://dx.doi.org/10.1016/j.drudis.2018.02.012] [PMID: 29501911]
[http://dx.doi.org/10.1080/2162402X.2015.1115641] [PMID: 26942095]
[http://dx.doi.org/10.1158/1078-0432.CCR-10-3126] [PMID: 21471425]
[http://dx.doi.org/10.1093/jnci/djq295] [PMID: 20668267]
[http://dx.doi.org/10.1007/s40259-015-0140-7] [PMID: 26403092]
[http://dx.doi.org/10.1158/1078-0432.CCR-16-0712] [PMID: 28087644]
[http://dx.doi.org/10.1002/cam4.371] [PMID: 25619164]
[http://dx.doi.org/10.1056/NEJMoa1411087] [PMID: 25482239]
[http://dx.doi.org/10.2217/mmt-2017-0018] [PMID: 30190923]
[http://dx.doi.org/10.1056/NEJMoa1200694] [PMID: 22658128]
[http://dx.doi.org/10.1038/s41598-017-06002-8] [PMID: 28717238]
[http://dx.doi.org/10.1007/s40265-017-0782-5] [PMID: 28643244]
[PMID: 9377574]
[http://dx.doi.org/10.1016/S0140-6736(07)61904-7] [PMID: 18156031]
[http://dx.doi.org/10.1186/s40942-016-0026-y] [PMID: 27847621]
[http://dx.doi.org/10.1007/s00280-013-2182-1] [PMID: 23673444]
[http://dx.doi.org/10.1158/1078-0432.CCR-04-2658] [PMID: 16061863]
[http://dx.doi.org/10.1056/NEJMoa0708857] [PMID: 18650514]
[http://dx.doi.org/10.1200/JCO.2005.02.2194] [PMID: 16314617]
[http://dx.doi.org/10.1038/nrd2012] [PMID: 16628834]
[http://dx.doi.org/10.1007/s40265-015-0483-x] [PMID: 26487541]
[http://dx.doi.org/10.2147/CMAR.S74202] [PMID: 25709499]
[http://dx.doi.org/10.1158/1078-0432.CCR-15-0600] [PMID: 26048277]
[http://dx.doi.org/10.1080/14737140.2016.1182430] [PMID: 27144874]
[http://dx.doi.org/10.1016/j.critrevonc.2013.08.012] [PMID: 24041629]
[http://dx.doi.org/10.1517/13543784.17.2.253] [PMID: 18230058]
[http://dx.doi.org/10.1158/1535-7163.MCT-11-0264] [PMID: 21926191]
[http://dx.doi.org/10.1007/978-3-642-54490-3_12] [PMID: 24756794]
[http://dx.doi.org/10.1056/NEJMoa1510016] [PMID: 26406150]
[http://dx.doi.org/10.1056/NEJMoa1109653] [PMID: 22149876]
[http://dx.doi.org/10.3109/10428194.2012.728597] [PMID: 22966948]
[http://dx.doi.org/10.1016/j.mvr.2008.08.003] [PMID: 18805433]
[http://dx.doi.org/10.1016/j.ctrv.2015.11.003] [PMID: 26678514]
[http://dx.doi.org/10.1007/s40265-015-0383-0] [PMID: 25795101]
[PMID: 26254357]
[http://dx.doi.org/10.1038/bjc.2012.153] [PMID: 22568966]
[http://dx.doi.org/10.1016/S0140-6736(12)61857-1] [PMID: 23177515]
[http://dx.doi.org/10.1182/blood-2007-10-117457] [PMID: 18245666]
[http://dx.doi.org/10.1111/j.1600-0609.2012.01775.x] [PMID: 22404182]
[http://dx.doi.org/10.1210/jc.2009-2461] [PMID: 20371662]
[http://dx.doi.org/10.1358/dot.2006.42.10.1025318] [PMID: 17136225]
[http://dx.doi.org/10.1007/s11899-017-0418-6]
[http://dx.doi.org/10.1182/blood.V122.21.2617.2617]
[http://dx.doi.org/10.1371/journal.pone.0222551] [PMID: 32294103]
[http://dx.doi.org/10.1186/s13046-018-0702-x] [PMID: 29506529]
[http://dx.doi.org/10.21037/atm.2019.10.116] [PMID: 31930041]
[http://dx.doi.org/10.1097/PAI.0000000000000594] [PMID: 29346180]
[http://dx.doi.org/10.1016/j.jtho.2016.11.2228] [PMID: 27913228]
[http://dx.doi.org/10.1002/wsbm.1263] [PMID: 24604755]
[http://dx.doi.org/10.3389/fonc.2013.00062] [PMID: 23565501]
[http://dx.doi.org/10.1371/journal.pone.0015482] [PMID: 21151630]
[http://dx.doi.org/10.1038/clpt.2012.243] [PMID: 23419487]
[http://dx.doi.org/10.1038/nrclinonc.2015.204] [PMID: 26598946]
[http://dx.doi.org/10.2165/00003495-199856060-00006] [PMID: 9878990]
[http://dx.doi.org/10.1158/1078-0432.CCR-07-0088] [PMID: 17575239]
[http://dx.doi.org/10.1002/wsbm.1198] [PMID: 23184638]
[http://dx.doi.org/10.3389/fonc.2020.01030] [PMID: 32695678]
[http://dx.doi.org/10.1038/s41587-019-0332-7] [PMID: 31792411]
[http://dx.doi.org/10.1053/j.gastro.2017.02.039] [PMID: 28284560]
[http://dx.doi.org/10.3390/ijms20194781] [PMID: 31561483]
[http://dx.doi.org/10.1038/nature10933] [PMID: 22495314]
[http://dx.doi.org/10.1517/phgs.5.3.331.29830] [PMID: 15102547]
[http://dx.doi.org/10.1093/bioinformatics/btx766] [PMID: 29186355]
[http://dx.doi.org/10.1056/NEJMoa043331] [PMID: 15758010]
[http://dx.doi.org/10.1093/bib/bby072] [PMID: 30137230]
[http://dx.doi.org/10.1038/s42256-019-0019-2] [PMID: 30801055]
[http://dx.doi.org/10.3174/ajnr.A5667] [PMID: 29748206]
[http://dx.doi.org/10.1038/nature21056] [PMID: 28117445]
[http://dx.doi.org/10.1088/1361-6579/aaf34d] [PMID: 30523982]
[http://dx.doi.org/10.1371/journal.pone.0178751] [PMID: 28582401]
[http://dx.doi.org/10.1038/tp.2015.7] [PMID: 25710120]
[http://dx.doi.org/10.1371/journal.pone.0043855] [PMID: 22952789]
[http://dx.doi.org/10.1007/s10803-014-2268-6] [PMID: 25294649]
[http://dx.doi.org/10.1007/s10803-018-3696-5] [PMID: 30043354]
[http://dx.doi.org/10.1038/s41591-018-0279-0] [PMID: 30617323]
[http://dx.doi.org/10.1016/j.jbi.2013.10.010] [PMID: 24184678]
[http://dx.doi.org/10.2174/138920212800793294] [PMID: 23204920]
[http://dx.doi.org/10.1038/35057062] [PMID: 11237011]
[http://dx.doi.org/10.1038/s41588-018-0288-4] [PMID: 30559488]
[http://dx.doi.org/10.1038/gim.2017.246] [PMID: 29323667]
[http://dx.doi.org/10.1126/science.1254806] [PMID: 25525159]
[http://dx.doi.org/10.1038/nmeth.3547] [PMID: 26301843]
[http://dx.doi.org/10.1016/j.molonc.2012.02.005] [PMID: 22469618]
[http://dx.doi.org/10.1517/17530059.2.7.829] [PMID: 19122861]
[http://dx.doi.org/10.3390/jpm6010013] [PMID: 26927187]
[http://dx.doi.org/10.1155/2016/1680464] [PMID: 27239470]
[http://dx.doi.org/10.1093/bioinformatics/btl196] [PMID: 16709585]
[http://dx.doi.org/10.1007/s00262-010-0968-0] [PMID: 21267721]
[http://dx.doi.org/10.1016/j.ejrad.2015.11.013] [PMID: 26590851]
[http://dx.doi.org/10.1016/j.ejrad.2009.01.050] [PMID: 19303233]
[http://dx.doi.org/10.1016/B978-0-12-411638-2.00007-0] [PMID: 25287691]
[http://dx.doi.org/10.1155/2014/819324] [PMID: 24689058]
[http://dx.doi.org/10.1152/physrev.00049.2010] [PMID: 22535898]
[http://dx.doi.org/10.1155/2017/7039406] [PMID: 28812019]
[http://dx.doi.org/10.2176/nmc.ra.2015-0305]
[http://dx.doi.org/10.1002/jmri.25173] [PMID: 26854494]
[http://dx.doi.org/10.1161/CIRCRESAHA.110.234146] [PMID: 21617135]
[http://dx.doi.org/10.1016/j.addr.2013.09.007] [PMID: 24064465]
[http://dx.doi.org/10.1148/radiol.11110252] [PMID: 21493796]
[http://dx.doi.org/10.1016/j.semcancer.2015.09.007] [PMID: 26590477]
[http://dx.doi.org/10.1177/1534735407309623] [PMID: 18048883]
[http://dx.doi.org/10.1039/b715668p] [PMID: 18820757]
[http://dx.doi.org/10.1158/2159-8290.CD-13-0452] [PMID: 24706659]
[http://dx.doi.org/10.1002/1521-3765(20020916)8:18<4191:AID-CHEM4191>3.0.CO;2-S] [PMID: 12298009]
[http://dx.doi.org/10.1038/nrc2824] [PMID: 20332778]
[http://dx.doi.org/10.1038/nrd4505] [PMID: 25743081]
[http://dx.doi.org/10.1016/j.chembiol.2006.10.005] [PMID: 17185224]
[http://dx.doi.org/10.1016/j.bcp.2004.12.001] [PMID: 15748702]
[http://dx.doi.org/10.1038/nm.4389] [PMID: 28886003]
[PMID: 23055749]
[http://dx.doi.org/10.1021/mp900243b] [PMID: 20108971]
[http://dx.doi.org/10.1038/sj.bjc.6690174] [PMID: 10098741]
[http://dx.doi.org/10.3816/CBC.2000.s.009] [PMID: 11970749]
[http://dx.doi.org/10.2174/1568011054222364] [PMID: 16101488]
[http://dx.doi.org/10.1158/1078-0432.CCR-14-3252] [PMID: 25838395]
[http://dx.doi.org/10.1007/s00280-015-2863-z] [PMID: 26416565]
[http://dx.doi.org/10.3748/wjg.v21.i43.12234] [PMID: 26604633]
[http://dx.doi.org/10.1186/s11658-019-0164-y] [PMID: 31223315]
[http://dx.doi.org/10.1586/era.10.88] [PMID: 20645688]
[PMID: 24404355]
[http://dx.doi.org/10.1038/bjc.2014.149] [PMID: 24755886]
[http://dx.doi.org/10.1155/2019/7479518] [PMID: 31341477]
[http://dx.doi.org/10.3389/fphar.2019.01461] [PMID: 32009943]
[http://dx.doi.org/10.4161/cbt.19604] [PMID: 22415137]
[http://dx.doi.org/10.3892/br.2016.720] [PMID: 27602208]
[http://dx.doi.org/10.1016/j.critrevonc.2018.05.019] [PMID: 29958633]
[http://dx.doi.org/10.1517/13543780802691068] [PMID: 19236265]
[http://dx.doi.org/10.1016/j.currproblcancer.2007.04.001] [PMID: 17645940]
[http://dx.doi.org/10.1002/ardp.200900319] [PMID: 20726007]
[http://dx.doi.org/10.1007/s11010-008-9903-5] [PMID: 18759062]
[http://dx.doi.org/10.5625/lar.2014.30.4.143] [PMID: 25628724]
[http://dx.doi.org/10.1038/nchembio776] [PMID: 16532013]
[http://dx.doi.org/10.1038/sj.bjc.6604642] [PMID: 19034280]
[http://dx.doi.org/10.1016/j.tiv.2014.04.011] [PMID: 24759803]
[http://dx.doi.org/10.1080/10286020.2010.489040] [PMID: 20706898]
[http://dx.doi.org/10.1016/j.taap.2006.12.025] [PMID: 17306316]
[http://dx.doi.org/10.3390/cancers11071003] [PMID: 31319622]
[http://dx.doi.org/10.1038/nature06915] [PMID: 18385730]
[http://dx.doi.org/10.1038/nrd3651] [PMID: 22322254]
[http://dx.doi.org/10.4155/bio.12.325] [PMID: 23394702]
[http://dx.doi.org/10.1016/0163-7258(87)90099-4] [PMID: 3324117]
[http://dx.doi.org/10.1016/0165-1110(94)90015-9] [PMID: 7527485]
[PMID: 1884379]
[http://dx.doi.org/10.1073/pnas.1205943109] [PMID: 22927417]
[http://dx.doi.org/10.1016/j.dnarep.2015.01.011] [PMID: 25758781]
[http://dx.doi.org/10.1038/nchembio.1986] [PMID: 26656090]
[http://dx.doi.org/10.1016/j.bcp.2011.10.005] [PMID: 22015635]
[http://dx.doi.org/10.1016/S0167-8140(99)00009-2] [PMID: 10225551]
[http://dx.doi.org/10.1016/S0305-7372(98)90056-1] [PMID: 9861196]
[http://dx.doi.org/10.1016/S0006-2952(98)00307-4] [PMID: 10075079]
[http://dx.doi.org/10.1126/science.6093249] [PMID: 6093249]
[http://dx.doi.org/10.1111/j.1749-6632.2003.tb05972.x] [PMID: 12724222]
[http://dx.doi.org/10.1158/1535-7163.MCT-08-0860] [PMID: 19509247]
[http://dx.doi.org/10.1016/S1470-2045(02)00932-4] [PMID: 12473517]
[http://dx.doi.org/10.2217/epi.14.62] [PMID: 25687460]
[http://dx.doi.org/10.1038/labinvest.2015.148] [PMID: 26692290]
[http://dx.doi.org/10.18632/oncotarget.11750] [PMID: 27589687]
[PMID: 27152238]
[http://dx.doi.org/10.1016/j.cell.2015.07.011] [PMID: 26317466]
[http://dx.doi.org/10.4155/ppa.15.16] [PMID: 26174566]
[http://dx.doi.org/10.1038/nm.3952] [PMID: 26390243]
[http://dx.doi.org/10.18632/oncotarget.1408] [PMID: 24077805]
[http://dx.doi.org/10.1038/nature10866] [PMID: 22343889]
[http://dx.doi.org/10.1038/ng1834] [PMID: 16804544]
[http://dx.doi.org/10.1038/nrclinonc.2013.42] [PMID: 23546521]
[http://dx.doi.org/10.1158/0008-5472.CAN-05-2385] [PMID: 16707479]
[http://dx.doi.org/10.1002/adma.201705660] [PMID: 29504159]
[http://dx.doi.org/10.1039/C9AN02041A] [PMID: 32196042]
[http://dx.doi.org/10.1002/adma.201906783] [PMID: 32253807]
[http://dx.doi.org/10.1039/C6BM00441E] [PMID: 27480033]
[http://dx.doi.org/10.1007/978-3-642-36025-1]
[http://dx.doi.org/10.1016/j.gendis.2017.04.001] [PMID: 28944281]
[http://dx.doi.org/10.1093/bib/bbv060] [PMID: 26249224]
[http://dx.doi.org/10.1056/NEJMoa0804385] [PMID: 18946061]
[http://dx.doi.org/10.1016/S1470-2045(10)70130-3] [PMID: 20619739]
[http://dx.doi.org/10.1186/s13054-017-1836-5] [PMID: 29047353]
[http://dx.doi.org/10.1186/gm538] [PMID: 25031615]
[http://dx.doi.org/10.1038/nature15393] [PMID: 26432245]
[http://dx.doi.org/10.1200/JCO.2010.29.6103] [PMID: 21098321]
[http://dx.doi.org/10.1016/S0140-6736(16)32232-2] [PMID: 27924764]
[http://dx.doi.org/10.1056/NEJMsb042458] [PMID: 15625341]
[http://dx.doi.org/10.1080/23808993.2018.1421858] [PMID: 29682615]
[http://dx.doi.org/10.1016/j.jcpo.2016.09.003]
[http://dx.doi.org/10.1038/s41698-017-0032-z] [PMID: 29872710]
[http://dx.doi.org/10.1038/nrd4694] [PMID: 26228747]
[http://dx.doi.org/10.1001/jama.2016.14117] [PMID: 27669484]