Natural Product as Substrates of ABC Transporters: A Review

Title:Natural Product as Substrates of ABC Transporters: A Review

Volume: 16 Issue: 2

Author(s): Xuan-Yu Chen, Jing-Quan Wang, Yuqi Yang, Jing Li*Zhe-Sheng Chen*

Affiliation:

• College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017,China

• Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, New York11439,United States

Keywords: Natural product, ABC transporter, anticancer activity, substrate, multidrug resistance, breast cancer.

Abstract:

Background: To date, many compounds extracted from natural products have anti-tumor activity, such as citronellol, ellagitannin-containing pomegranate extract, etc. Evidence from clinical context shows that multidrug resistance is an obstacle that impedes the effectiveness of natural products, such as chemotherapeutic agents, paclitaxel and vincristine. Overexpression of ATP- Binding Cassette (ABC) transporters is the leading cause of MDR. Therefore, it is crucial to investigate whether these natural products are substrates of MDR-associated ABC transporters, which may benefit the development of their clinical usage.

Objective: This review summarizes the latest insight on natural products possessing substrate profile and analyzes some possible directions for future drug discovery.

Conclusion: The anti-tumor effects of natural products are constantly being explored, but the drug resistance issues cannot be ignored, which limits their prospects as anti-tumor drugs to a certain extent. At the same time, some natural products are taken as a daily diet, and their possible role in increasing the drug resistance of the substrate should arouse the attention of clinical cancer patients.

Cite this article as:

Chen Xuan-Yu , Wang Jing-Quan , Yang Yuqi , Li Jing *, Chen Zhe-Sheng *, Natural Product as Substrates of ABC Transporters: A Review, Recent Patents on Anti-Cancer Drug Discovery 2021; 16 (2) . https://dx.doi.org/10.2174/1574892816666210218220943