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Current Women`s Health Reviews

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ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

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Case Report

Sarcoidosis and Sarcoid Reactions in Endometrial Cancer Cases Masquerading Advanced Stage Malignancy

Author(s): Serkan Akis*, Canan Kabaca, Esra Keles, Handan Cetiner and Hatice Akay

Volume 18, Issue 1, 2022

Published on: 08 February, 2021

Article ID: e061221191217 Pages: 4

DOI: 10.2174/1573404817666210208163237

Price: $65

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Abstract

Background: Sarcoidosis is usually diagnosed by ruling out other granulomatous inflammatory diseases. Rarely, it may be suspected with a pathological examination after surgical intervention for another disease. The sarcoid reaction is noninfectious granulomatous lymphadenitis, which can occur at nodes draining a neoplasm. We demonstrated granulomatous lesions masquerading metastasis by Positron Emission Tomography/Computed Tomography (PET/CT) in endometrial cancer. We presented two cases of endometrial cancer with sarcoidosis and sarcoid-like reactions because of their challenging clinical and radiological findings.

Cases: In case 1, there was diffuse granulomatous inflammation (no metastasis) in lymph nodes (n = 92) and giant cells containing calcifications (Schaumann bodies). In case 2, PET/CT revealed hypermetabolism with malignancy suspicion in the pelvic lymph nodes (maximum standardized uptake value= 13) and pathological evaluation reported a 4.5 cm tumor within the uterine cavity without any nodal metastasis.

Results: PET/CT has no role in the evaluation of differential diagnosis between granulomatous lymphadenitis and metastatic disease.

Conclusion: Granulomatous lesions might mimic the metastasis of coexisting malignant diseases.

Keywords: Cancer staging, endometrial cancer, lymph node, sarcoidosis, sarcoid reaction, schaumann bodies.

Graphical Abstract

[1]
Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Müller QJ. Sarcoidosis. Lancet 2014; 383(9923): 1155-67.
[http://dx.doi.org/10.1016/S0140-6736(13)60680-7] [PMID: 24090799]
[2]
Brincker H. Sarcoid reactions in malignant tumours. Cancer Treat Rev 1986; 13(3): 147-56.
[http://dx.doi.org/10.1016/0305-7372(86)90002-2] [PMID: 3536088]
[3]
Mell LK, Carmona R, Gulaya S, et al. Cause-specific effects of radiotherapy and lymphadenectomy in stage I-II endometrial cancer: a population-based study. J Natl Cancer Inst 2013; 105(21): 1656-66.
[http://dx.doi.org/10.1093/jnci/djt279] [PMID: 24123960]
[4]
Costabel U, Hunninghake GW. Sarcoidosis statement committee. American thoracic society. European respiratory society. World association for sarcoidosis and other granulomatous disorders. ATS/ERS/WASOG statement on sarcoidosis. Eur Respir J 1999; 14(4): 735-7.
[http://dx.doi.org/10.1034/j.1399-3003.1999.14d02.x] [PMID: 10573213]
[5]
Mapelli P, Mangili G, Picchio M, et al. Sarcoidosis mimicking metastatic gynaecological malignancies: A diagnostic and therapeutic challenge? Rev Esp Med Nucl Imagen Mol 2013; 32(5): 314-7.
[PMID: 23270913]
[6]
Park HJ, Jung JI, Chung MH, et al. Typical and atypical manifestations of intrathoracic sarcoidosis. Korean J Radiol 2009; 10(6): 623-31.
[http://dx.doi.org/10.3348/kjr.2009.10.6.623] [PMID: 19885319]
[7]
Ungprasert P, Carmona EM, Crowson CS, Matteson EL. Diagnostic utility of angiotensin-converting enzyme in sarcoidosis: A population-based study. Lung 2016; 194(1): 91-5.
[http://dx.doi.org/10.1007/s00408-015-9826-3] [PMID: 26563332]
[8]
Arfi J, Kerrou K, Traore S, et al. F-18 FDG PET/CT findings in pulmonary necrotizing sarcoid granulomatosis. Clin Nucl Med 2010; 35(9): 697-700.
[http://dx.doi.org/10.1097/RLU.0b013e3181e9fade] [PMID: 20706045]
[9]
Asano S. Granulomatous lymphadenitis. J Clin Exp Hematop 2012; 52(1): 1-16.
[http://dx.doi.org/10.3960/jslrt.52.1] [PMID: 22706525]
[10]
Karam M, Roberts-Klein S, Shet N, Chang J, Feustel P. Bilateral hilar foci on 18F-FDG PET scan in patients without lung cancer: Variables associated with benign and malignant etiology. J Nucl Med 2008; 49(9): 1429-36.
[http://dx.doi.org/10.2967/jnumed.107.048983] [PMID: 18765585]
[11]
Lashari BH, Asai M, Randleman G, Sack M, Patel R. Sarcoid-like mediastinal lymphadenopathy in gynecologic malignancy. Pulm Med 2018; 2018
[http://dx.doi.org/10.1155/2018/5141575] [PMID: 29666703]

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