Abstract
Most of the tripartite motif (TRIM) family proteins have E3 ubiquitin ligase activities and also have a variety of functions in cellular processes such as intracellular signal transduction, apoptosis, innate immunity, and carcinogenesis. TRIM65 is a member of the TRIM family. More pieces of evidence have shown a unique role and importance of TRIM65 protein in the occurrence and development of some diseases. In this review, the importance of TRIM65 in white matter lesions, innate immunity, and the effect of tumors were mainly reviewed.
Keywords: TRIM65, white matter lesions, innate immunity, carcinogenesis, E3 ubiquitin ligase, tumor.
Graphical Abstract
Call for Papers in Thematic Issues
Advances in the Diagnosis and Treatment of Head and Neck Disease
Head and neck diseases encompass a wide range of conditions affecting the oral cavity, pharynx, larynx, nasal passages, sinuses, salivary glands, and other structures of the head and neck region. These diseases can have significantly on essential function, such as breathing, swallowing, speaking, as well as the quality of life. ...read more
Common Mechanisms Underpinning Neurodevelopmental Disorders and Psychiatric Diseases
A growing number of large-scale epidemiologic studies have strongly suggested that common mechanisms may be shared by aberrant brain development and psychiatric disorders. There is now an appreciation of the synergic roles of genetic variants and environmental stress, which profoundly affect genome integrity and reshape brain development. This can lead ...read more
New Cell Death Regulation Drugs for Cardiovascular Diseases
Cardiovascular diseases are the leading cause of mortality worldwide, with aberrant cell death processes playing a crucial role in their pathogenesis. Cell death in these diseases encompasses not only well-studied forms of apoptosis but also includes a variety of complex modes such as mitochondrial permeability transition (MPT)-driven necrosis, entotic cell ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Current Drug Targets
Current Drug Therapy
Related Books
Anthocyanins: Pharmacology and Nutraceutical Importance
The Roles and Responsibilities of Clinical Pharmacists in Hospital Settings
Bioactive Compounds from Medicinal Plants for Cancer Therapy and Chemoprevention
Drug Addiction Mechanisms in the Brain
Software and Programming Tools in Pharmaceutical Research
Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep
Medicinal Chemistry of Drugs Affecting Cardiovascular and Endocrine Systems
Advanced Pharmacy
Plant-derived Hepatoprotective Drugs
The Role of Chromenes in Drug Discovery and Development
34