Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy

doi:10.2174/1568009621666210203110305
摘要

背景：肺癌在全球癌症相关死亡中位居首位，需要新的策略来治疗这种威胁生命的疾病。本综述的目的是探讨肺癌中长链非编码 RNA (lncRNAs) 对上皮间质转化 (EMT) 的调控。简介：LncRNA 可以被认为是癌症治疗靶向的潜在因素，因为它们调节了一系列生物过程，例如。细胞增殖、分化和凋亡。 lncRNAs的异常表达发生在不同的癌细胞中。另一方面，上皮间质转化（EMT）是参与癌细胞迁移和转移的关键机制。方法：使用“LncRNA”、“EMT”和“肺癌”等关键词搜索不同的数据库，包括Google Scholar、Pubmed和Science direct，收集文章。结果：存在抑制肺癌细胞EMT和转移的肿瘤抑制lncRNAs。此类 lncRNA 的表达在肺癌进展中经历下调，恢复其表达对于抑制肺癌迁移具有重要意义。有促进肿瘤的 lncRNAs 在肺癌中触发 EMT 并增强它们的迁移。结论：LncRNAs 是肺癌 EMT 的潜在调节因子，在药理学和遗传学上靶向它们对于控制肺癌细胞的迁移具有重要意义。
关键词: 肺癌，长链非编码 RNA，上皮间质转化，转移，癌症治疗，microRNA，钙粘蛋白。
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图形摘要

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DOI https://dx.doi.org/10.2174/1568009621666210203110305	Print ISSN 1568-0096
Publisher Name Bentham Science Publisher	Online ISSN 1873-5576
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Innovative Cancer Drug Targets: A New Horizon in Oncology

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当代肿瘤药物靶点

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摘要

图形摘要

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