Semisynthetic Triazoles as an Approach in the Discovery of Novel Lead Compounds

Pedro    Alves Bezerra    Morais; Carla    Santana    Francisco; Heberth       de Paula; Rayssa       Ribeiro; Mariana    Alves    Eloy; Clara    Lirian    Javarini; Álvaro    Cunha    Neto; Valdemar    Lacerda    Júnior
doi:10.2174/1385272825666210126100227
Abstract

Historically, medicinal chemistry has been concerned with the approach of organic chemistry for new drug synthesis. Considering the fruitful collections of new molecular entities, the dedicated efforts for medicinal chemistry are rewarding. Planning and search for new and applicable pharmacologic therapies involve the altruistic nature of the scientists. Since the 19th century, notoriously applying isolated and characterized plant-derived compounds in modern drug discovery and various stages of clinical development highlight its viability and significance. Natural products influence a broad range of biological processes, covering transcription, translation, and post-translational modification, being effective modulators of most basic cellular processes. The research of new chemical entities through “click chemistry” continuously opens up a map for the remarkable exploration of chemical space towards leading natural products optimization by structure-activity relationship. Finally, in this review, we expect to gather a broad knowledge involving triazolic natural product derivatives, synthetic routes, structures, and their biological activities.
Keywords: Triazole, heterocyclic, natural products, semisynthesis, lead compounds, drug discovery.
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DOI https://dx.doi.org/10.2174/1385272825666210126100227	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348
Current Organic Chemistry

Semisynthetic Triazoles as an Approach in the Discovery of Novel Lead Compounds

Abstract

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Advances of Heterocyclic Chemistry with Pesticide Activity

Carbohydrates conversion in biofuels and bioproducts

Catalytic C-H bond activation as a tool for functionalization of heterocycles

Cutting-edge technology for the development of electrochemical sensors

Current Organic Chemistry

Semisynthetic Triazoles as an Approach in the Discovery of Novel Lead Compounds

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Advances of Heterocyclic Chemistry with Pesticide Activity

Carbohydrates conversion in biofuels and bioproducts

Catalytic C-H bond activation as a tool for functionalization of heterocycles

Cutting-edge technology for the development of electrochemical sensors

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