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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

非编码 RNA 和 N6-甲基腺苷对癌症的影响：过去、现在和未来

卷 21, 期 5, 2021

发表于: 20 January, 2021

页: [375 - 385] 页: 11

弟呕挨: 10.2174/1568009621999210120193636

价格: $65

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摘要

N6-甲基腺苷 (m6A) 修饰控制多方面的 RNA 代谢，是人类转录组上分布最广泛的修饰之一，包括非编码 RNA (ncRNA)。之前将 ncRNA 视为“垃圾”转录产物的概念已经演变为 ncRNA 是决定特定生物过程和细胞命运的功能调节分子的概念。 m6A 修饰和 ncRNA 的失调与人类致癌作用的发展有关。据报道，某些类型的 ncRNA 对 m6A 机制发挥调节作用。然而，仍然需要更好地了解 m6A 修饰与癌症中 ncRNA 之间的关系。本综述讨论了 m6A 修饰和 ncRNA 之间的相互作用及其对人类癌症发展的影响。我们总结了 m6A-ncRNA 网络对癌症诊断和治疗的临床意义，并提出了在该研究领域仍未得到解答的具有挑战性的问题。了解 m6A 修饰和 ncRNA 之间的复杂协调将有助于指导治疗干预的发展。

关键词: N6-甲基腺苷、miRNA、LncRNA、CircRNA、PiRNA、非编码RNA、癌症。

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图形摘要

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