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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Marine Sponge-Associated Fungi as Potential Novel Bioactive Natural Product Sources for Drug Discovery: A Review

Author(s): Bin Zhang, Ting Zhang, Jianzhou Xu, Jian Lu, Panpan Qiu, Tingting Wang* and Lijian Ding*

Volume 20, Issue 19, 2020

Page: [1966 - 2010] Pages: 45

DOI: 10.2174/1389557520666200826123248

Price: $65

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Abstract

Marine sponge-associated fungi are promising sources of structurally interesting and bioactive secondary metabolites. Great plenty of natural products have been discovered from spongeassociated fungi in recent years. Here reviewed are 571 new compounds isolated from marine fungi associated with sponges in 2010-2018. These molecules comprised eight different structural classes, including alkaloids, polyketides, terpenoids, meroterpenoids, etc. Moreover, most of these compounds demonstrated profoundly biological activities, such as antimicrobial, antiviral, cytotoxic, etc. This review systematically summarized the structural diversity, biological function, and future potential of these novel bioactive natural products for drug discovery.

Keywords: Sponge-associated fungi, natural products, antimicrobial, antiviral, cytotoxic, lead drugs.

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