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Review Article

Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches

Author(s): Natália F.F. Pirolla, Victor S. Batista, Flávia Pereira Dias Viegas, Vanessa Silva Gontijo, Caitlin R. McCarthy, Claudio Viegas* and Nailton M. Nascimento-Júnior*

Volume 22, Issue 5, 2021

Published on: 19 August, 2020

Page: [505 - 538] Pages: 34

DOI: 10.2174/1389450121999200819144544

Price: $65

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Abstract

We describe herein the therapeutic targets involved in Alzheimer’s disease as well as the available drugs and their synthetic routes. Bioactive compounds under development are also exploited to illustrate some recent research advances on the medicinal chemistry of Alzheimer’s disease, including structure-activity relationships for some targets. The importance of multi-target approaches, including some examples from our research projects, guides new perspectives in search of more effective drug candidates. This review comprises the period between 2001 and early 2020.

Keywords: Alzheimer's disease, structure-activity relationship, multi-target-directed ligands, acetylcholinesterase, nicotinic acetylcholine receptors, synthetic routes.

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