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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity

Author(s): Esmaeil Sheikh Ahmadi, Amir Tajbakhsh, Milad Iranshahy, Javad Asili, Nadine Kretschmer, Abolfazl Shakeri* and Amirhossein Sahebkar

Volume 20, Issue 19, 2020

Page: [2019 - 2035] Pages: 17

DOI: 10.2174/1389557520666200818212020

Price: $65

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Abstract

Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are the subject of increasing attention due to their promising biological activities such as antioxidant, antimicrobial, apoptosis-inducing activities, and especially anticancer activity. Lapachol, lapachone, and napabucasin belong to the NQs and are in phase II clinical trials for the treatment of many cancers. This review aims to provide a comprehensive and updated overview on the biological activities of several new NQs isolated from different species of plants reported from January 2013 to January 2020, their potential therapeutic applications and their clinical significance.

Keywords: Naphthoquinone, cytotoxic, antibacterial, clinical trial, cancer, biological activity.

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