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Current Radiopharmaceuticals

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ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

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General Research Article

Extremity Exposure with 99mTc - Labelled Radiopharmaceuticals in Diagnostic Nuclear Medicine

Author(s): Mpumelelo Nyathi*, Thabiso Maria Moeng and Doctor Paul A Maboe

Volume 14, Issue 1, 2021

Published on: 27 July, 2020

Page: [57 - 63] Pages: 7

DOI: 10.2174/1874471013999200727205451

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Abstract

Background: Extremity exposures may raise the risk of cancer induction among radiographers involved in the preparation and administration of technetium-99m labelled radiopharmaceuticals.

Objective: To estimate finger doses on radiographers at a South African tertiary hospital.

Methods: Adhesive tape was used to securely fix a calibrated thermoluminescent dosimeter (TLD) on fingertips and bases of ring and index fingers of both hands of five radiographers who prepared and administered technetium-99m labelled radiopharmaceuticals. Rubber gloves were worn to avoid TLD contamination. TLDs doses were read with a Harsaw TLD Reader (Model 3500) after a week.

Results: Five radiographers prepared and administered technitium-99m labelled radiopharmaceuticals (activity range; 78.20 GBq - 132.78 GBq during a one-week measurement period). A radiographer handling 132.78 GBq received 4.74±0.52 mSv on both hands; 5.52, 4.55, 5.11 and 4.60 mSv on the fingertip of the index finger of the dominant hand (FIDH), fingertip of the ring finger of the dominant hand (FRDH), fingertip of the index finger of the non-dominant hand (FINDH) and fingertip of the ring finger of the non-dominant hand (FRNDH), respectively. The respective doses received on the finger bases were 4.50 mSv, 4.60, 4.21 and 3.48 mSv. The radiographer handling 78.20 GBq received 0.85±0.18 mSv on both hands, 1.04, 1.17, 0.77 and 1 mSv for the FIDH, FRDH, FINDH and FRNDH, respectively, while respective doses for the bases were 0.8, 0.9, 0.6 and 0.8 mSv.

Conclusion: The extremity exposures were below the annual limit (500 mSv). However, the use of syringe shields could still reduce the finger doses further.

Keywords: Finger doses, nuclear medicine, technetium-99m labelled radiopharmaceuticals, thermoluminescent dosimeters.

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[1]
Yonekura, Y.; Mattsson, S.; Flux, G.; Bolch, W.T.; Fisher, D.R.; Lassman, M.; Doruff, M.; Divgi, C.; Zanzonico, P. ICRP Publication 140: Radiological Protection in Therapy with Radiopharmaceuticals 2019.
[2]
Mettler, F.A.; Guiberteau, M.J. Essentials of the Nuclear Medicine Imaging, 5th ed; Saunders Elsevier, 2006.
[3]
Payolla, F.B.; Massabni, A.C.; Orvig, C. Radiopharmaceuticals for diagnosis in nuclear medicine: a short review Eclética Química Journal, 2019, 44(3), 11-19.
[4]
Gano, L.; Paulo, A. Conventional Nuclear Medicine Radiopharmaceuticals., https://www.eanm.org/content-eanm/uploads/2019/11/EANM19_TechGuide-1.pdf
[5]
Cherry, S.R.; Sorenson, J.A.; Phelps, M.E. Physics of Nuclear Medicine, 4th ed; Elsevier Science, 2012.
[6]
Davey, R.J.; AuBuchon, J.P. Post-Transfusion Red Blood Cell and Platelet Survival and Kinetics: Basic Principles and Practical Aspects
[7]
Nairne, J.; Iveson, P.B.; Meijer, A. Imaging in drug development. Prog. Med. Chem., 2015, 54, 231-280.
[http://dx.doi.org/10.1016/bs.pmch.2014.10.002] [PMID: 25727706]
[8]
Buckley, P.T.; Dugan, D.L.; Elliston, J.T.; Filby, R.H.; Paulenova, A. Radioisotopes in Medicne: Preparing a Technitium-99m Generator and determining its efficiency. J. Chem. Educ., 2006, 83(4), 625-627.
[http://dx.doi.org/10.1021/ed083p625]
[9]
Ejeh, J.E.; Abiodun, T.H.; Adedapo, K.S.; Onimode, Y.A.; Ayeni, O.A. Radiation levels from toilets used by patients injected with 99mTc –based radiopharmaceuticals in Iban. Mol. Imaging Radionucl. Ther., 2014, 23(2), 60-63.
[http://dx.doi.org/10.4274/mirt.82905] [PMID: 24963447]
[10]
Gilmore, D.; Tempesta, D. 2014.Generators used in nuclear medicine., https://www.eanm.org/content-eanm/uploads/2019/11/EANM19_TechGuide-1.pdf
[11]
Vucina, J.; Lukie, D. Radionuclide generators for the production of technetium-99m and rhenium-188. Phys. Chemtech, 2002, 2(4), 235-243.
[12]
Quantitative Nuclear Medicine Imaging; Concepts, Requirements and Methods IAEA Human Health Series N0. 9: Vienna, Austria, 2014.
[13]
Bolus, N.E. Review of common occupational hazards and safety concerns for nuclear medicine technologists. J. Nucl. Med. Technol., 2008, 36(1), 11-17.
[http://dx.doi.org/10.2967/jnmt.107.043869] [PMID: 18287195]
[14]
Pant, G.S.; Sharma, S.K.; Rath, G.K. Finger doses for staff handling radiopharmaceuticals in nuclear medicine. J. Nucl. Med. Technol., 2006, 34(3), 169-173.
[PMID: 16951286]
[15]
Vanhavere, F.; Carinou, E.; Carnicer, A.; Baechler, S.; Barth, I.; Bordy, J.M.; Bilski, P. Extremity exposure in diagnostic nuclear medicine with 18F and 99mTc labelled radiopharmaceutical:. Optimization of Radiation Protection of Medical Staff; Barcelona, 2011.https: //www.oramed-fp7.eu/en/Presentations
[16]
Donadille, L.; Baechler, S.; Barth, I. Extremity exposure in nuclear medicine: Work package 4 of the Project; Optimization of Radiation Protection of Medical Staff, 2011.https://www.oramed-fp7.eu/en/Presentations
[17]
Leszczynski, D. The Grand Challenge: use of a new approach in developing policies in the area of radiation and health Frontiers in health, 2014, 2(50), 1-4.
[http://dx.doi.org/10.3389/fpubh.2014.00050]
[18]
International Commission on Radiological Protection. ICRP Publication 60; Recommendation of the ICRP Pergamon Press: New York, 1991.
[19]
Carnicer, A.; Baechler, S.; Barth, I. Extremity exposure in diagnostic nuclear medicine with 18F and 99mTc labelled radiopharmaceuticals Optimization of Radiation Protection of Medical Staff. Barcelona, 2011.https://www.oramed-fp7.eu/en/Presentations
[20]
Nyathi, M. Establishment of Diagnostic Reference Levels and estimation of Effective Dose from Computed Tomography Head Scans at a TertiaryHospital in South Africa Iran J Med Phys, 2020, 17(2)
[21]
Burke, K.; Sutton, D. Optimization and deconvolution of lithium fluoride TLD-100 in diagnostic radiology. Br. J. Radiol., 1997, 70, 261-271.
[http://dx.doi.org/10.1259/bjr.70.831.9166051] [PMID: 9166051]
[22]
Pant, G.S.; Sharma, S.K.; Bal, C.S.; Kumar, R.; Rath, G.K. Radiation dose to family members of hyperthyroidism and thyroid cancer patients treated with 131I. Radiat. Prot. Dosimetry, 2006, 118(1), 22-27.
[http://dx.doi.org/10.1093/rpd/nci337] [PMID: 16105892]
[23]
Jankowski, J.; Olszewski, J.; Kluska, K. Distribution of equivalent doses to skin of the hands of nuclear medicine personnel. Radiat. Prot. Dosimetry, 2003, 106(2), 177-180.
[http://dx.doi.org/10.1093/oxfordjournals.rpd.a006347] [PMID: 14653338]
[24]
Chruscielewski, W.; Olszewski, J.; Jankowski, J.; Cygan, M. Hand exposure in nuclear medicine workers. Radiat. Prot. Dosimetry, 2002, 101(1-4), 229-232.
[http://dx.doi.org/10.1093/oxfordjournals.rpd.a005973] [PMID: 12382741]
[25]
Harding, L.K.; Hesslewood, S.; Ghose, S.K.; Thomson, W.H. The value of syringe shields in a nuclear medicine department. Nucl. Med. Commun., 1985, 6(8), 449-454.
[http://dx.doi.org/10.1097/00006231-198508000-00004] [PMID: 4069470]
[26]
Piwowarska-Bilska. Supinska, A.; Listewnik, M.H. Radiation doses of employees on nuclear medicine department after implementation of more rigorous radiation protection methods; Radiat Prot Dosim, 2013, pp. 1-4.

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