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Review Article

姜黄素：靶向树突状细胞表型和功能的饮食植物化学物质

卷 28, 期 8, 2021

发表于: 15 May, 2020

页: [1549 - 1564] 页: 16

弟呕挨: 10.2174/0929867327666200515101228

价格: $65

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摘要

树突状细胞（DC）是连接先天和适应性免疫反应的最强大的抗原呈递细胞。根据于上下文，DC启动免疫反应或促进免疫耐受。它们的表型和功能的任何紊乱都可能引发炎性或自身免疫性疾病。因此，失调的DCs是旨在降低其免疫原性并增强其耐受性的新疗法开发的最有吸引力的药理学靶标。姜黄素是香料姜黄的多酚植物化学成分，具有广泛的药理活性。它以多种方式充当DC的调制器，并将其转换为耐受DC。致耐受性DC具有调节健康和疾病中免疫反应的抗炎和免疫调节活性。姜黄素通过阻断成熟标志物，细胞因子和趋化因子的表达，并破坏DC的抗原呈递机制，使DC对免疫刺激剂无反应或反应低下。它也减少了共刺激分子和粘附分子在DC上的表达，并阻止它们迁移和抗原呈递，但增强了它们的内吞能力。因此，姜黄素会引起DC诱导的调节性T细胞，并抑制CD4 + T辅助物1（Th1），Th2和Th17极化。转录因子（如NF-κB，AP-1，MAPKs（p38，JNK，ERK）和其他细胞内信号分子（如JAK / STAT / SOCS）的抑制为大多数这些观察提供了合理的解释。在这篇综述中，我们总结了姜黄素对DC的表型和功能的潜在影响，DC是协调，刺激和调节免疫反应的关键因素。

关键词: 姜黄素，免疫调节剂，树突状细胞，自身免疫，炎症，硬膜外植物化学物质，树突状细胞。

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