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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Research Article

弥漫性大型B细胞淋巴瘤埃及患者中丙型肝炎病毒感染和治疗的独立预后因素

卷 20, 期 8, 2020

页: [638 - 645] 页: 8

弟呕挨: 10.2174/1568009620666200511084731

价格: $65

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摘要

背景：埃及是最高的丙型肝炎病毒（HCV）流行地区之一。 慢性HCV感染具有肝外表现，包括非霍奇金淋巴瘤（NHL）。 弥漫性大B细胞淋巴瘤（DLBCL）通常与HCV感染相关。 迄今为止，HCV感染和HCV治疗对DLBCL患者的预后价值尚不清楚。 目的：我们的研究目的是评估HCV感染和HCV治疗作为独立预后因素对埃及HCV相关DLBCL患者无事件生存期（EFS）和总体生存期（OS）的影响。 方法：本研究回顾性收集了353例DLBCL患者。 前瞻性收集了34例接受HCV抗病毒治疗的HCV患者。 诊断时从患者记录中收集患者的特征。 还记录了有关HCV感染和HCV治疗的患者状况。 病历，复发，再治疗或死亡也通过医疗记录进行了验证。 计算了EFS和OS。 结果：与未感染HCV和HCV治疗的患者相比，HCV感染和HCV未治疗的患者的EFS和OS显着降低。 使用单变量和多变量分析，HCV感染而非HCV治疗与EFS和OS独立相关。 结论：丙型肝炎病毒感染是弥漫性大B细胞淋巴瘤EFS和OS的独立预后因素。 HCV治疗与较高的EFS和OS相关，但不能视为独立的预后因素。

关键词: 弥漫性大B细胞淋巴瘤，HCV，病毒性肝炎，生存，癌症，预后。

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