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Review Article

聚（ADP-核糖）聚合酶（PARP）抑制剂和合成方法的综述

卷 28, 期 8, 2021

发表于: 12 March, 2020

页: [1565 - 1584] 页: 20

弟呕挨: 10.2174/0929867327666200312113011

价格: $65

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摘要

聚（ADP-核糖）聚合酶（PARP）是一种必不可少的DNA修复酶。 PARP抑制剂是一种基于“合成致死性”原理的新型小分子靶向药物，可通过竞争性抑制PARP酶的活性来影响DNA修复过程，从而杀死癌细胞。 当前，包括olaparib，rucaparib，niraparib和talazoparib在内的4种PARP抑制剂已被FDA批准用于癌症治疗，并在卵巢癌，乳腺癌和胰腺癌等治疗方面取得了巨大成功。 PARP抑制剂的研究进展，包括主要结构类型，构效关系（SAR）和合成途径，旨在为新型PARP抑制剂的发现和合成提供思路。

关键词: 卵巢癌，合成杀伤力，PARP抑制剂，奥拉帕尼，构效关系，邻苯二酮，合成。

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