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Anti-Cancer Agents in Medicinal Chemistry

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ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

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Research Article

Development of A Novel System Based on Green Magnetic / Graphene Oxide / Chitosan /Allium Sativum / Quercus / Nanocomposite for Targeted Release of Doxorubicin Anti-Cancer Drug

Author(s): Omid Arjmand, Mehdi Ardjmand*, Ali M. Amani and Mohmmad H. Eikani

Volume 20, Issue 9, 2020

Page: [1094 - 1104] Pages: 11

DOI: 10.2174/1871520620666200213105203

Price: $65

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Abstract

Background: Doxorubicin, as a strong anti-cancer agent for clinical treatment of various cancer types along with other drugs, is widely utilized. Due to the physiology of the human body and cancerous tissues, the applicability of doxorubicin is still limited and the targeted treatment of the different types of cancers is considered. Also, the side effects of the conventional forms of chemotherapy medicines, damaging and stressing the normal cells are considerable.

Objective: This study introduces a novel and effective system for the targeted release of doxorubicin by successfully fabricating the green magnetic graphene oxide, chitosan, allium sativum, and quercus nanocomposite.

Methods: The in vitro release of doxorubicin loaded on the nanocomposite was evaluated and investigated at pH 7.4 and 6.5, respectively. The drug diffusivity in the plasma environment was assessed for a more accurate analysis of the drug diffusion process. The nanocomposite loaded drug release mechanism and kinetics, as well as cytotoxicity assay was investigated.

Results: The efficiency of the drug encapsulation was significantly enhanced using natural extract ingredients and consequently, the efficacy of the targeted treatment of cancerous tissues was improved. The developed nanocomposite provided a controlled release of doxorubicin in similar acidic conditions of the normal and cancerous cells and affirming that the fabricated system is thoroughly pH-dependent.

Conclusion: The cytotoxicity assay confirmed that the fabricated nanocomposite at a high growth rate of cancerous cells has an anticancer property and acts as a toxic agent against tumor cells, suggesting that in conjunction with doxorubicin, it can be highly improved for killing cancerous cells.

Keywords: Drug release, doxorubicin, anticancer agent, drug diffusivity, natural components, kinetics models.

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[1]
Bernstein, C.; Prasad, A.R.; Nfonsam, V.; Bernstein, H. Bernstein. DNA damage, DNA repair and cancer. New Res. Directions DNA Repair, 2013, 16, 413-465.
[2]
Nagai, H.; Kim, Y.H. Cancer prevention from the perspective of global cancer burden patterns. J. Thorac. Dis., 2017, 9(3), 448-451.
[http://dx.doi.org/10.21037/jtd.2017.02.75 ] [PMID: 28449441]
[3]
Ji, R.C. Lymph nodes and cancer metastasis: New perspectives on the role of intranodal lymphatic sinuses. Int. J. Mol. Sci., 2016, 18(1), 51.
[http://dx.doi.org/10.3390/ijms18010051 ] [PMID: 28036019]
[4]
Zaorsky, N.G.; Churilla, T.M.; Egleston, B.L.; Fisher, S.G.; Ridge, J.A.; Horwitz, E.M.; Meyer, J.E. Causes of death among cancer patients. Ann. Oncol., 2017, 28(2), 400-407.
[http://dx.doi.org/10.1093/annonc/mdw604 ] [PMID: 27831506]
[5]
Huang, C.Y.; Ju, D.T.; Chang, C.F.; Muralidhar Reddy, P.; Velmurugan, B.K. A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine (Taipei), 2017, 7(4), 23.
[http://dx.doi.org/10.1051/bmdcn/2017070423 ] [PMID: 29130448]
[6]
Trypuć, A.J.; Świderski, G.; Krętowski, R.; Lewandowski, W.Ł. Newly synthesized doxorubicin complexes with selected metals-synthesis, structure and anti-breast cancer activity. Molecules, 2017, 22(7), 1106.
[http://dx.doi.org/10.3390/molecules22071106]
[7]
Yang, F.; Teves, S.S.; Kemp, C.J.; Henikoff, S. Doxorubicin, DNA torsion, and chromatin dynamics. Biochim. Biophys. Acta., 2014, 1845(1), 84-89.
[PMID: 24361676]
[8]
Mitra, A.K.; Agrahari, V.; Mandal, A.; Cholkar, K.; Natarajan, C.; Shah, S.; Joseph, M.; Trinh, H.M.; Vaishya, R.; Yang, X.; Hao, Y.; Khurana, V.; Pal, D. Novel delivery approaches for cancer therapeutics. J. Control. Release, 2015, 219, 248-268.
[http://dx.doi.org/10.1016/j.jconrel.2015.09.067 ] [PMID: 26456750]
[9]
Tamarov, K.; Näkki, S.; Xu, W.; Lehto, V.P. Approaches to improve the biocompatibility and systemic circulation of inorganic porous nanoparticles. J. Mater. Chem. B Mater. Biol. Med., 2018, 6, 3632-3649.
[http://dx.doi.org/10.1039/C8TB00462E]
[10]
Li, L.; Wang, J.; Kong, H.; Zeng, Y.; Liu, G. Functional biomimetic nanoparticles for drug delivery and theranostic applications in cancer treatment. Sci. Technol. Adv. Mater., 2018, 19(1), 771-790.
[http://dx.doi.org/10.1080/14686996.2018.1528850 ] [PMID: 30815042]
[11]
Zhang, B.; Cheng, G.; Zheng, M.; Han, J.; Wang, B.; Li, M.; Chen, J.; Xiao, T.; Zhang, J.; Cai, L.; Li, S.; Fan, X. Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment. Drug Deliv., 2018, 25(1), 461-471.
[http://dx.doi.org/10.1080/10717544.2018.1435750 ] [PMID: 29426237]
[12]
Ramalingam, V.; Varunkumar, K.; Ravikumar, V.; Rajaram, R. Target delivery of doxorubicin tethered with PVP stabilized gold nanoparticles for effective treatment of lung cancer. Sci. Rep., 2018, 8(1), 3815.
[http://dx.doi.org/10.1038/s41598-018-22172-5 ] [PMID: 29491463]
[13]
Yigit, M.V.; Balcioglu, M.; Rana, M. Doxorubicin loading on graphene oxide, iron oxide and gold nanoparticle hybrid. J. Mater. Chem. B Mater. Biol. Med., 2013, 1(45), 6179-6344.
[14]
Ebrahimi, E.; Khandaghi, A.A.; Valipour, F.; Babaie, S.; Asghari, F.; Motaali, S.; Abbasi, E.; Akbarzadeh, A.; Davaran, S. In vitro study and characterization of doxorubicin-loaded magnetic nanoparticles modified with biodegradable copolymers. Artif. Cells Nanomed. Biotechnol., 2016, 44(2), 550-558.
[http://dx.doi.org/10.3109/21691401.2014.968822 ] [PMID: 25345419]
[15]
Yan, T.; Zhang, H.; Huang, D.; Feng, S.; Fujita, M.; Gao, X.D. Chitosan-functionalized graphene oxide as a potential immunoadjuvant. Nanomaterials (Basel), 2017, 7(3), 59.
[http://dx.doi.org/10.3390/nano7030059 ] [PMID: 28336893]
[16]
Khoee, S.; Bafkary, R.; Fayyazi, F. DOX delivery based on chitosan - capped graphene oxidemesoporous silica nanohybride as pH-responsive nanocarriers. J. Sol-Gel Sci. Technol., 2016, 81(2), 493-504.
[http://dx.doi.org/10.1007/s10971-016-4213-y]
[17]
Mousavia, S.M.; Hashemia, S.A.; Hashemia, A.M. Amania, E.H.; Ghasemia, Y.; Babapoor, A.; Mojoudid, F.; Arjmand, O. Pb(II) removal from synthetic wastewater using kombucha scoby and graphene oxide/Fe3O4. Phys. Chem. Res., 2018, 6(4), 759-771.
[18]
Wu, Y.; Yang, J.; Gao, H.; Shen, Y.; Jiang, L.; Zhou, C.; Li, Y.; He, R.; Liu, M. Folate-conjugated halloysite nanotubes, an efficient drug carrier deliver doxorubicin for targeted therapy of breast cancer. ACS Appl. Nano Mater., 2017, 1(2), 595-608.
[http://dx.doi.org/10.1021/acsanm.7b00087]
[19]
Noorunnisa Khanam, P.; Hasan, A. Biosynthesis and characterization of graphene by using non-toxic reducing agent from Allium Cepa extract: Anti-bacterial properties. Int. J. Biol. Macromol., 2019, 126(1), 151-158.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.12.213 ] [PMID: 30584937]
[20]
Kim, C.J. Controlled Release Dosage Form Design, 3rd ed; CRC Press: New York, 2000.

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