Abstract
Glioblastoma multiforme (GBM) is characterized by poor prognosis despite an aggressive therapeutic strategy. In recent years, many advances have been achieved in the field of glioblastoma biology.
Here we try to summarize the main clinical and biological factors impacting clinical prognostication and therapy of GBM patients. From that standpoint, hopefully, in the near future, personalized therapies will be available.
Keywords: Glioblastoma, prognostic factor, predictive response, Glioblastoma multiforme (GBM).
[http://dx.doi.org/10.1007/s10072-016-2747-y] [PMID: 27807698]
[http://dx.doi.org/10.1016/S1470-2045(09)70025-7] [PMID: 19269895]
[http://dx.doi.org/10.1007/s00401-007-0243-4] [PMID: 17618441]
[http://dx.doi.org/10.1186/s12916-015-0536-8] [PMID: 26646075]
[http://dx.doi.org/10.1158/0008-5472.CAN-04-1337] [PMID: 15466178]
[http://dx.doi.org/10.1111/j.1750-3639.1996.tb00848.x] [PMID: 8864278]
[http://dx.doi.org/10.1056/NEJMoa0808710] [PMID: 19228619]
[http://dx.doi.org/10.1007/s00401-017-1690-1] [PMID: 28255664]
[http://dx.doi.org/10.1016/j.archger.2009.06.011] [PMID: 19628288]
[http://dx.doi.org/10.1002/ana.21521] [PMID: 19107984]
[http://dx.doi.org/10.1016/j.ijrobp.2015.06.025] [PMID: 26530769]
[http://dx.doi.org/10.1200/JCO.2005.04.5963] [PMID: 16735709]
[http://dx.doi.org/10.1002/1531-8249(199908)46:2<183:AID-ANA7>3.0.CO;2-7] [PMID: 10443883]
[http://dx.doi.org/10.3171/2009.9.JNS09805] [PMID: 19817542]
[http://dx.doi.org/10.1245/s10434-017-5843-1] [PMID: 28321691]
[http://dx.doi.org/10.3171/2013.9.JNS13877] [PMID: 24205904]
[http://dx.doi.org/10.3171/2014.7.JNS132449] [PMID: 25192475]
[http://dx.doi.org/10.1093/nop/npu021] [PMID: 26034628]
[http://dx.doi.org/10.1016/S1470-2045(05)01767-5] [PMID: 15737833]
[http://dx.doi.org/10.1007/s002340050556] [PMID: 9561517]
[PMID: 16286386]
[PMID: 23691466]
[http://dx.doi.org/10.1148/radiographics.16.6.8946545] [PMID: 8946545]
[http://dx.doi.org/10.1073/pnas.0801279105] [PMID: 18362333]
[http://dx.doi.org/10.1007/s11060-015-1766-5] [PMID: 25862005]
[http://dx.doi.org/10.1007/s00259-017-3618-3] [PMID: 28110346]
[http://dx.doi.org/10.1007/s00259-007-0531-1] [PMID: 17710394]
[http://dx.doi.org/10.1007/s00401-015-1432-1] [PMID: 25943888]
[http://dx.doi.org/10.1056/NEJMoa043331] [PMID: 15758010]
[http://dx.doi.org/10.1056/NEJM200011093431901] [PMID: 11070098]
[http://dx.doi.org/10.1016/S1470-2045(12)70164-X] [PMID: 22578793]
[http://dx.doi.org/10.1186/s12957-016-1012-4] [PMID: 27733166]
[http://dx.doi.org/10.1155/2017/8013575] [PMID: 28316990]
[http://dx.doi.org/10.1007/s00401-015-1405-4] [PMID: 25752754]
[http://dx.doi.org/10.1371/journal.pone.0007752] [PMID: 19915670]
[http://dx.doi.org/10.1002/glia.20895] [PMID: 19533602]
[http://dx.doi.org/10.1215/15228517-2008-026] [PMID: 18562769]
[http://dx.doi.org/10.1038/bjc.2015.242] [PMID: 26291053]
[http://dx.doi.org/10.1093/neuonc/nou344] [PMID: 25543125]
[http://dx.doi.org/10.1016/j.canlet.2013.12.003] [PMID: 24333730]
[http://dx.doi.org/10.1007/s00401-010-0645-6] [PMID: 20127344]
[http://dx.doi.org/10.1097/WCO.0b013e32834cd415] [PMID: 22002076]
[http://dx.doi.org/10.1097/MD.0000000000002583] [PMID: 26945349]
[http://dx.doi.org/10.1016/j.humpath.2017.05.005] [PMID: 28549927]
[http://dx.doi.org/10.1126/science.277.5332.1630] [PMID: 9287210]
[http://dx.doi.org/10.1242/dev.02419] [PMID: 16728475]
[http://dx.doi.org/10.2174/156652409788488739] [PMID: 19601808]
[http://dx.doi.org/10.1523/JNEUROSCI.5385-07.2008] [PMID: 18524891]
[http://dx.doi.org/10.1016/j.mce.2017.01.004] [PMID: 28089821]
[http://dx.doi.org/10.1158/1078-0432.CCR-05-2202] [PMID: 16818690]
[http://dx.doi.org/10.3892/ijo.16.2.413] [PMID: 10639586]
[http://dx.doi.org/10.1038/sj.onc.1201455] [PMID: 9419966]
[http://dx.doi.org/10.1016/B978-0-12-802997-8.00023-2] [PMID: 26948367]
[http://dx.doi.org/10.1126/science.2134734] [PMID: 2134734]
[http://dx.doi.org/10.1016/j.humpath.2015.05.014] [PMID: 26190195]
[http://dx.doi.org/10.1038/nrdp.2017.4] [PMID: 28230061]
[http://dx.doi.org/10.1023/A:1025689004046] [PMID: 14558604]
[http://dx.doi.org/10.1200/JCO.2006.06.3891] [PMID: 16954518]
[http://dx.doi.org/10.1016/S0360-3016(00)00703-3] [PMID: 11020580]
[http://dx.doi.org/10.1186/s40478-018-0544-y] [PMID: 29890994]
[http://dx.doi.org/10.1038/modpathol.2012.166] [PMID: 23429602]
[http://dx.doi.org/10.1016/j.molonc.2013.12.010] [PMID: 24412053]
[http://dx.doi.org/10.1158/0008-5472.CAN-05-0137] [PMID: 16024602]
[http://dx.doi.org/10.1016/j.canlet.2012.10.025] [PMID: 23142218]
[http://dx.doi.org/10.3791/60215] [PMID: 31633695]
[http://dx.doi.org/10.1111/bph.12008] [PMID: 23062197]
[http://dx.doi.org/10.1155/2013/979748] [PMID: 23864770]
[http://dx.doi.org/10.1002/jnr.20266] [PMID: 15378607]
[http://dx.doi.org/10.1074/jbc.M807170200] [PMID: 19074142]
[http://dx.doi.org/10.1007/s11060-012-0875-7] [PMID: 22528800]
[http://dx.doi.org/10.1084/jem.20111424] [PMID: 22393126]
[http://dx.doi.org/10.1007/s12032-012-0432-4] [PMID: 23283648]
[http://dx.doi.org/10.1053/j.seminoncol.2014.04.006] [PMID: 25023351]
[http://dx.doi.org/10.18632/oncotarget.15235] [PMID: 28223536]
[http://dx.doi.org/10.1007/s11060-013-1164-9] [PMID: 23780645]
[http://dx.doi.org/10.1186/s13148-017-0316-8] [PMID: 28184256]
[http://dx.doi.org/10.1523/JNEUROSCI.5812-12.2013] [PMID: 23986257]
[http://dx.doi.org/10.1016/j.mehy.2013.02.022] [PMID: 23541771]
[PMID: 31046428]