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Review Article

像它们的药代动力学一样将其呈现为纳米颗粒后，药物的药效学会发生变化吗？

卷 21, 期 8, 2020

页: [807 - 818] 页: 12

弟呕挨: 10.2174/1389450121666200128113547

价格: $65

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摘要

如今，在不同医学领域的突破使得设计新的药物递送方法变得可行，从而获得最具成本效益和最不令人不快的结果，从而提出了解决多种疾病的解决方案。纳米（NP）药物进入了治疗系统，尤其是在癌症化学疗法中。这些药物以长效和低毒性两个特性而闻名。长期以来，已经研究了NPs如何改变药物动力学。但是，有一些研究使他们的注意力转向了NPs如何影响药物动力学。在这篇综述中，后一点将主要以基于示例的方式进行讨论。此外，将简要说明NP的其他特定功能。 NP与药物一样能够影响生物系统。而且，NP通过触发它们自己的受体而可能产生各种各样的作用。 NP能够改变受体功能并操纵其下游信号传导级联。

关键词: 纳米粒子，药效学，受体后效应，药物-受体相互作用，药物传递，药物动力学。

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