Login Register Cart 0
Meta-Analysis

益生元产品对降低超重和肥胖个体肥胖参数的影响:一项系统综述和Meta分析

卷 28, 期 2, 2021

发表于: 30 December, 2019

页: [419 - 431] 页: 13

弟呕挨: 10.2174/0929867327666191230110128

价格: $65

conference banner
摘要

背景：益生元是宿主微生物选择性利用的底物，对健康有益。一些临床和动物研究表明益生元具有降低超重/肥胖个体体重的潜力。然而，这些研究都是基于相对较小的样本量，而益生元产品的精确效果尚未得到评估。因此，本研究通过随机对照试验(RCTs)的荟萃分析，全面评估益生元产品对超重和肥胖个体的影响。 方法：检索PubMed、EMBASE和Cochrane图书馆，以确定RCT调查益生元产品对超重和肥胖个体的影响。我们计算了合并加权平均差(WMD)来评估益生元产品对身体质量指数(BMI)、体重、脂肪质量和炎症生物标志物的影响。 结果：共有535名超重和肥胖个体参加了12项随机对照试验。与安慰剂相比，益生元产品降低了C反应蛋白(WMD， -1.06 mg/L;95%CI， -1.72 ~ - 0.40;p=0.002)、肿瘤坏死因子-α(WMD， -0.64 pg/mL;95%CI， -1.11 ~ -0.18;p=0.006)和其他炎症标志物如白细胞介素-1β、脂多糖(p<0.05);BMI (WMD， -0.20 kg/m2;95%CI， -0.58 ~ 0.19;p=0.32)，体重(WMD， -0.51 kg;95%CI， -1.18 - 0.16;p=0.14)和脂肪质量(WMD, 0.11 kg;95%CI， -0.04 ~ 0.25;观察p = 0.15)。 结论：在目前的分析,全面的证据表明生命起源以前的产品没有减少肥胖症参数(体重指数、体重和体脂量),但他们可以减少系统性炎症生物标记物的水平,这意味着坚持生命起源以前的产品可能是一个有前途的互补方法管理炎症在超重和肥胖的人。

关键词: 益生元，超重，肥胖，炎症，肠道微生物群，meta分析，BMI。

« Previous
[1]
Gregor, M.F.; Hotamisligil, G.S. Inflammatory mechanisms in obesity. Annu. Rev. Immunol., 2011, 29, 415-445.
[http://dx.doi.org/10.1146/annurev-immunol-031210-101322] [PMID: 21219177]
[2]
Montague, C.T.; O’Rahilly, S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes, 2000, 49(6), 883-888.
[http://dx.doi.org/10.2337/diabetes.49.6.883] [PMID: 10866038]
[3]
van Herpen, N.A.; Schrauwen-Hinderling, V.B. Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol. Behav., 2008, 94(2), 231-241.
[http://dx.doi.org/10.1016/j.physbeh.2007.11.049] [PMID: 18222498]
[4]
Symons, J.D.; Abel, E.D. Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide. Rev. Endocr. Metab. Disord., 2013, 14(1), 59-68.
[http://dx.doi.org/10.1007/s11154-012-9235-3] [PMID: 23292334]
[5]
Gualillo, O. Mediators of inflammation in obesity and its comorbidities. Mediators Inflamm., 2010, 2010, 1-2.
[http://dx.doi.org/10.1155/2010/239126] [PMID: 20885924]
[6]
Kang, C.; Wang, B.; Kaliannan, K.; Wang, X.; Lang, H.; Hui, S.; Li, H.; Zhang, Y.; Zhou, M.; Chen, M.; Mi, M. Gut microbiota mediates the protective effects of dietary capsaicin against chronic low-grade inflammation and associated obesity induced by high-fat diet. MBio, 2017, 8(3), e00470-e17.
[http://dx.doi.org/10.1128/mBio.00470-17] [PMID: 28536285]
[7]
Boulangé, C.L.; Neves, A.L.; Chilloux, J.; Nicholson, J.K.; Dumas, M-E. Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med., 2016, 8(1), 42.
[http://dx.doi.org/10.1186/s13073-016-0303-2] [PMID: 27098727]
[8]
Pindjakova, J.; Sartini, C.; Lo Re, O.; Rappa, F.; Coupe, B.; Lelouvier, B.; Pazienza, V.; Vinciguerra, M. Gut dysbiosis and adaptive immune response in diet-induced obesity vs. systemic inflammation. Front. Microbiol., 2017, 8, 1157.
[http://dx.doi.org/10.3389/fmicb.2017.01157] [PMID: 28690599]
[9]
de Vrese, M.; Schrezenmeir, J. Probiotics, prebiotics, and synbiotics. Adv. Biochem. Eng. Biotechnol., 2008, 111, 1-66.
[http://dx.doi.org/10.1007/10_2008_097] [PMID: 18461293]
[10]
Bindels, L.B.; Delzenne, N.M.; Cani, P.D.; Walter, J. Towards a more comprehensive concept for prebiotics. Nat. Rev. Gastroenterol. Hepatol., 2015, 12(5), 303-310.
[http://dx.doi.org/10.1038/nrgastro.2015.47] [PMID: 25824997]
[11]
Gibson, G.R.; Hutkins, R.; Sanders, M.E.; Prescott, S.L.; Reimer, R.A.; Salminen, S.J.; Scott, K.; Stanton, C.; Swanson, K.S.; Cani, P.D.; Verbeke, K.; Reid, G. Expert consensus document: the international scientific association for probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat. Rev. Gastroenterol. Hepatol., 2017, 14(8), 491-502.
[http://dx.doi.org/10.1038/nrgastro.2017.75] [PMID: 28611480]
[12]
Nicolucci, A.C.; Hume, M.P.; Martínez, I.; Mayengbam, S.; Walter, J.; Reimer, R.A. Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology, 2017, 153(3), 711-722.
[http://dx.doi.org/10.1053/j.gastro.2017.05.055] [PMID: 28596023]
[13]
Fernandes, R.; Beserra, B.T.S.; Mocellin, M.C.; Kuntz, M.G.F.; da Rosa, J.S.; de Miranda, R.C.D.; Schreiber, C.S.O.; Forde, T.S.; Nunes, E.A.; Trindade, E.B.S.M. Effects of prebiotic and synbiotic supplementation on inflammatory markers and anthropometric indices after Roux-en-Y gastric bypass: a randomized, triple-blind, placebo-controlled pilot study. J. Clin. Gastroenterol., 2016, 50(3), 208-217.
[http://dx.doi.org/10.1097/mcg.0000000000000328] [PMID: 25909598]
[14]
Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D.G. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med., 2009, 6(7)e1000097
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[15]
Higgins, J.P.T.; Altman, D.G.; Gøtzsche, P.C.; Jüni, P.; Moher, D.; Oxman, A.D.; Savovic, J.; Schulz, K.F.; Weeks, L.; Sterne, J.A. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ, 2011, 343, d5928.
[http://dx.doi.org/10.1136/bmj.d5928] [PMID: 22008217]
[16]
Vitaglione, P.; Mennella, I.; Ferracane, R.; Rivellese, A.A.; Giacco, R.; Ercolini, D.; Gibbsons, S.M.; Storia, A.L.; Gilbert, J.A.; Jonnalagadda, S.; Thielecke, F.; Gallo, M.A. Scalfi, l.; Fogliano, V. Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber. Am. J. Clin. Nutr., 2015, 101(2), 251-261.
[http://dx.doi.org/10.3945/ajcn.114.088120] [PMID: 25646321]
[17]
Parnell, J.A.; Klancic, T.; Reimer, R.A. Oligofructose decreases serum lipopolysaccharide and plas-minogen activator inhibitor-1 in adults with over-weight/obesity. Obesity (Silver Spring), 2017, 25(3), 510-513.
[http://dx.doi.org/10.1002/oby.21763] [PMID: 28229548]
[18]
Aliasgharzadeh, A.; Dehghan, P.; Gargari, B.P.; Asghari-Jafarabadi, M. Resistant dextrin, as a prebiotic, improves insulin resistance and inflammation in women with type 2 diabetes: a randomised controlled clinical trial. Br. J. Nutr., 2015, 113(2), 321-330.
[http://dx.doi.org/10.1017/s0007114514003675] [PMID: 27028002]
[19]
Dehghan, P.; Gargari, B.P.; Jafar-Abadi, M.A.; Aliasgharzadeh, A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int. J. Food Sci. Nutr., 2014, 65(1), 117-123.
[http://dx.doi.org/10.3109/09637486.2013.836738] [PMID: 24059649]
[20]
Roshanravan, N.; Mahdavi, R.; Alizadeh, E.; Ghavami, A.; Rahbar Saadat, Y.; Mesri Alamdari, N.; Alipour, S.; Dastouri, M.R.; Ostadrahimi, A. The effects of sodium butyrate and inulin supplementation on angiotensin signaling pathway via promotion of Akker-mansia muciniphila abundance in type 2 diabetes; A ran-domized, double-blind, placebo-controlled trial. J. Cardiovasc. Thorac. Res., 2017, 9(4), 183-190.
[http://dx.doi.org/10.15171/jcvtr.2017.32] [PMID: 29391930]
[21]
Stenman, L.K.; Lehtinen, M.J.; Meland, N.; Christensen, J.E.; Yeung, N.; Saarinen, M.T.; Courtney, M.; Burcelin, R.; Lähdeaho, M.L.; Linros, J.; Apter, D.; Scheinin, M.; Kloster Smerud, H.; Rissanen, A.; Lahtinen, S. Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults-randomized controlled trial. EBioMedicine, 2016, 13, 190-200.
[http://dx.doi.org/10.1016/j.ebiom.2016.10.036] [PMID: 27810310]
[22]
de Luis, D.A.; de la Fuente, B.; Izaola, O.; Conde, R.; Gutiérrez, S.; Morillo, M.; Teba Torres, C. Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients. Nutr. Hosp., 2011, 26(4), 827-833.
[http://dx.doi.org/10.1590/s0212-16112011000400024] [PMID: 22470031]
[23]
Canfora, E.E.; van der Beek, C.M.; Hermes, G.D.A.; Goossens, G.H.; Jocken, J.W.E.; Holst, J.J.; van Eijk, H.M.; Venema, K.; Smidt, H.; Zoetendal, E.G.; Dejong, C.H.C.; Lenaerts, K.; Blaak, E.E. Supplementation of diet with galacto-oligosaccharides increases bifidobacteria, but not insulin sensitivity, in obese prediabetic individuals. Gastroenterology, 2017, 153(1), 87-97.e3.
[http://dx.doi.org/10.1053/j.gastro.2017.03.051] [PMID: 28396144]
[24]
Lambert, J.E.; Parnell, J.A.; Tunnicliffe, J.M.; Han, J.; Sturzenegger, T.; Reimer, R.A. Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial. Clin. Nutr., 2017, 36(1), 126-133.
[http://dx.doi.org/10.1016/j.clnu.2015.12.016] [PMID: 26811130]
[25]
Reimer, R.A.; Willis, H.J.; Tunnicliffe, J.M.; Park, H.; Madsen, K.L.; Soto-Vaca, A. Inulin-type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight/obesity: A randomized controlled trial. Mol. Nutr. Food Res., 2017, 61(11)1700484
[http://dx.doi.org/10.1002/mnfr.201700484] [PMID: 28730743]
[26]
Farrington, R.; Musgrave, I.F.; Byard, R.W. Evidence for the efficacy and safety of herbal weight loss preparations. J. Integr. Med., 2019, 17(2), 87-92.
[http://dx.doi.org/10.1016/j.joim.2019.01.009] [PMID: 30738773]
[27]
Teschke, R.; Xuan, T.D. Viewpoint: a contributory role of shell ginger (Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm) for human longevity in okinawa, japan? Nutrients, 2018, 10(2), 166.
[http://dx.doi.org/10.3390/nu10020166] [PMID: 29385084]
[28]
Tu, P.T.; Tawata, S. Anti-oxidant, anti-aging, and anti-melanogenic properties of the essential oils from two varieties of Alpinia zerumbet. Molecules, 2015, 20(9), 16723-16740.
[http://dx.doi.org/10.3390/molecules200916723] [PMID: 26389869]
[29]
Ji, Y.P.; Shi, T.Y.; Zhang, Y.Y.; Lin, D.; Linghu, K.G.; Xu, Y.N.; Tao, L.; Lu, Q.; Shen, X.C. Essential oil from fructus alpinia zerumbet (fruit of Alpinia zerumbet (Pers.) Burtt.et Smith) protected against aortic endothelial cell injury and inflammation in vitro and in vivo. J. Ethnopharmacol., 2019, 237, 149-158.
[http://dx.doi.org/10.1016/j.jep.2019.03.011] [PMID: 30880260]
[30]
Be Tu, P.T.; Chompoo, J.; Tawata, S. Hispidin and related herbal compounds from Alpinia zerumbet inhibit both PAK1-dependent melanogenesis in melanocytes and reactive oxygen species (ROS) production in adipocytes. Drug Discov. Ther., 2015, 9(3), 197-204.
[http://dx.doi.org/10.5582/ddt.2015.01038] [PMID: 26193942]
[31]
Chen, Y.; Li, D.; Xu, Y.; Zhang, Y.; Tao, L.; Li, S.; Jiang, Y.; Shen, X. Essential oils from fructus A. zerumbet protect human aortic endothelial cells from apoptosis induced by Ox-LDL in vitro. Evid. Based Complement. Alternat. Med., 2014, 2014956824
[http://dx.doi.org/10.1155/2014/956824] [PMID: 25610487]
[32]
Tu, P.T.; Tawata, S. Anti-obesity effects of hispidin and Alpinia zerumbet bioactives in 3T3-L1 adipocytes. Molecules, 2014, 19(10), 16656-16671.
[http://dx.doi.org/10.3390/molecules191016656] [PMID: 25322285]
[33]
Bond, T.; Derbyshire, E. Tea compounds and the gut microbiome: findings from trials and mechanistic studies. Nutrients, 2019, 11(10), 2364.
[http://dx.doi.org/10.3390/nu11102364] [PMID: 31623411]
[34]
Jin, J-S.; Touyama, M.; Hisada, T.; Benno, Y. Effects of green tea consumption on human fecal microbiota with special reference to Bifidobacterium species. Microbiol. Immunol., 2012, 56(11), 729-739.
[http://dx.doi.org/10.1111/j.1348-0421.2012.00502.x] [PMID: 22924537]
[35]
Misaka, S.; Kawabe, K.; Onoue, S.; Werba, J.P.; Giroli, M.; Tamaki, S.; Kan, T.; Kimura, J.; Watanabe, H.; Yamada, S. Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes. Drug Metab. Pharmacokinet., 2013, 28(3), 244-249.
[http://dx.doi.org/10.2133/dmpk.DMPK-12-RG-101] [PMID: 23268924]
[36]
Cummings, J.H.; Macfarlane, G.T.; Englyst, H.N. Prebiotic digestion and fermentation. Am. J. Clin. Nutr., 2001, 73(2)(Suppl.), 415S-420S.
[http://dx.doi.org/10.1093/ajcn/73.2.415s] [PMID: 11157351]
[37]
Xu, B.; Wang, Y.; Li, J.; Lin, Q. Effect of prebiotic xylooligosaccharides on growth performances and digestive enzyme activities of allogynogenetic crucian carp (Carassius auratus gibelio). Fish Physiol. Biochem., 2009, 35(3), 351-357.
[http://dx.doi.org/10.1007/s10695-008-9248-8] [PMID: 18704733]
[38]
Alam, I.; Ng, T.P.; Larbi, A. Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective. Mediators Inflamm., 2012, 2012456456
[http://dx.doi.org/10.1155/2012/456456] [PMID: 23091306]
[39]
Ruderman, N.B.; Schneider, S.H.; Berchtold, P. The “metabolically-obese,” normal-weight individual. Am. J. Clin. Nutr., 1981, 34(8), 1617-1621.
[http://dx.doi.org/10.1093/ajcn/34.8.1617] [PMID: 7270486]
[40]
Zahorska-Markiewicz, B.; Janowska, J.; Olszanecka-Glinianowicz, M.; Zurakowski, A. Serum concentrations of TNF-α and soluble TNF-α receptors in obesity. Int. J. Obes. Relat. Metab. Disord., 2000, 24(11), 1392-1395.
[http://dx.doi.org/10.1038/sj.ijo.0801398] [PMID: 11126333]
[41]
Wunderlich, C.M.; Ackermann, P.J.; Ostermann, A.L.; Adams-Quack, P.; Vogt, M.C.; Tran, M-L.; Nikolajev, A.; Waisman, A.; Garbers, C.; Theurich, S.; Mauer, J.; Hövelmeyer, N.; Wunderlich, F.T. Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nat. Commun., 2018, 9(1), 1646.
[http://dx.doi.org/10.1038/s41467-018-03773-0] [PMID: 29695802]
[42]
Park, H.S.; Park, J.Y.; Yu, R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Res. Clin. Pract., 2005, 69(1), 29-35.
[http://dx.doi.org/10.1016/j.diabres.2004.11.007] [PMID: 15955385]
[43]
Wu, R.Y.; Määttänen, P.; Napper, S.; Scruten, E.; Li, B.; Koike, Y.; Johnson-Henry, K.C.; Pierro, A.; Rossi, L.; Botts, S.R.; Surette, M.G.; Sherman, P.M. Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota. Microbiome, 2017, 5(1), 135.
[http://dx.doi.org/10.1186/s40168-017-0357-4] [PMID: 29017607]
[44]
Johnson-Henry, K.C.; Pinnell, L.J.; Waskow, A.M.; Irrazabal, T.; Martin, A.; Hausner, M.; Sherman, P.M. Short-chain fructo-oligosaccharide and inulin modulate inflammatory responses and microbial communities in Caco2-bbe cells and in a mouse model of intestinal injury. J. Nutr., 2014, 144(11), 1725-1733.
[http://dx.doi.org/10.3945/jn.114.195081] [PMID: 25143376]
[45]
de Kivit, S.; Tobin, M.C.; Forsyth, C.B.; Keshavarzian, A.; Landay, A.L. Regulation of intestinal immune responses through tlr activation: implications for pro- and prebiotics. Front. Immunol., 2014, 5, 60.
[http://dx.doi.org/10.3389/fimmu.2014.00060] [PMID: 24600450]

Rights & Permissions Print Cite
Article Metrics
72
Wayfinder Image
World Antimicrobial Awareness Week
© 2024 Bentham Science Publishers | Privacy Policy