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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Application of Genetic Engineering Approaches to Improve Bacterial Metabolite Production

Author(s): Xin Xie, Jia-Wei Zhu, Yi Liu and Hui Jiang*

Volume 21, Issue 5, 2020

Page: [488 - 496] Pages: 9

DOI: 10.2174/1389203721666191223145827

Price: $65

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Abstract

Genetic engineering is a powerful method to improve the fermentation yield of bacterial metabolites. Since many biosynthetic mechanisms of bacterial metabolites have been unveiled, genetic engineering approaches have been applied to various issues of biosynthetic pathways, such as transcription, translation, post-translational modification, enzymes, transporters, etc. In this article, natamycin, avermectins, gentamicins, piperidamycins, and β-valienamine have been chosen as examples to review recent progress in improving their production by genetic engineering approaches. In these cases, not only yields of target products have been increased, but also yields of by-products have been decreased, and new products have been created.

Keywords: Metabolite, genetic engineering, biosynthesis, enzyme, fermentation, metabolites.

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