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Systematic Review Article

抗雄激素药物治疗强迫症：系统评价

卷 27, 期 40, 2020

页: [6825 - 6836] 页: 12

弟呕挨: 10.2174/0929867326666191209142209

价格: $65

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摘要

目的：本研究旨在系统地研究与强迫症患者相比，安慰剂或常规护理相比，抗雄激素药物是否可以显着减轻强迫症（OCD）症状。 方法：截至2018年10月，使用相关关键字搜索PubMed，EMBASE，CENTRAL和国际临床试验注册平台（ICTRP）数据库。包括对包括强迫症患者在内的强迫症患者进行的所有随机且非随机性非随机研究，这些患者报告了其症状的变化。排除强迫性性欲研究。所需数据是由两名独立作者从所收文章的全文中提取的。发现一项随机试验和四项非随机试验。 结果：唯一的随机试验表明，与安慰剂相比，抗雄激素药物氟他胺可有效降低男性合并性Tourette综合征强迫症患者的强迫评分。四分之三的非随机试验表明，包括非那雄胺，醋酸环丙孕酮和曲普瑞林在内的不同抗雄激素类药物均可有效减轻OCD症状。唯一的研究未能显示出抗雄激素药的功效，该研究给OCD患者服用了氟他胺。尽管取得了积极的成果，但现有的研究基于推荐，评估，发展和评估工作组（GRADE）方法的等级提供了低质量的证据。 结论：可用的研究不足以精确回答我们的研究问题。仍然需要进一步的大型随机盲临床试验来评估抗雄激素在强迫症患者中的有效性。建议在设计研究和解释其结果时应考虑性别，合并症和耶鲁-布朗强迫症评分表（Y-BOCS）。

关键词: 强迫症，促黄体激素释放激素，神经固醇，脱氢表雄酮，N-甲基-D-天冬氨酸，Tourette综合征。

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