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Mini-Review Article

槲皮素在帕金森氏病中的治疗潜力：对其分子和细胞调控的见解

卷 21, 期 5, 2020

页: [509 - 518] 页: 10

弟呕挨: 10.2174/1389450120666191112155654

价格: $65

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摘要

帕金森氏病（PD）是一种慢性进行性神经退行性疾病，其特征是黑质致密部（SNc）中的多巴胺能神经元进行性死亡。 PD是一种多因素疾病，提示几种不同的因素起着协同的病理生理作用，包括氧化应激，自噬，潜在的促炎事件和神经递质异常。总体而言，PD可被视为作用于给定遗传背景的环境因素之间复杂相互作用的产物。该主题的重要性已得到更多关注，以发现预防和治疗PD的新疗法。根据先前的研究，用于治疗PD的药物已显示出明显的局限性。因此，类黄酮在PD治疗中的作用已被广泛研究。槲皮素是一种来自类黄酮的植物类黄酮醇，被认为是PD的补充疗法。槲皮素通过控制不同的分子途径在PD中具有药理作用。尽管到目前为止，尚无旨在评估PD情况下槲皮素使用基础的研究，但目前，很少有证据可用于研究潜在的作用机理。这些治疗程序的各个主要方面仍然未知。在此，对支持槲皮素用于PD临床管理的现有知识进行了综述。

关键词: 槲皮素，帕金森氏病，多巴胺，炎性细胞因子，细胞凋亡，自噬。

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